Influence of exercise duration on cardiorespiratory responses, energy cost and tissue oxygenation within a 6 hour treadmill run

Dataset for results of 6TR study conducted at the University of the Sunshine Coas

Diversity of microbial communities derived from lungs of severe subtype cases and mild subtype and control individuals.

<p>(<b>a</b>) Pielou’s evenness and (<b>b</b>) Chao richness of microbial communities on genus level for severe vs mild/control samples. P-values were computed based on two-sided Wilcoxon-Mann-Whitney tests after correction for confounding effects from samples processed during winter or summer, respectively. (<b>c</b>) Phylogenetic community composition based on 16S rRNA gene fragment sequences in bronchial brushing samples. Bars represent the relative abundance of the most abundant families (>5% in one sample). The remaining families are subsumed as others.</p

Heatmap of genera showing significantly different abundances between severe versus mild subtype cases and controls.

<p>Genera showing significantly increased (<b>a</b>) or decreased (<b>b</b>) abundances in severe vs mild subtype cases and controls. Colors at the top represent COPD subtypes and controls. For each genus, samples were colored based on quartiles of non-zero abundances from light red to dark red. All Samples for which a genus was not present were colored in white.</p

Genus level community composition for COPD patients with and without abnormalities in CT and controls based on PCoA.

<p>(<b>a</b>) Lung derived microbial community composition in severe subtype COPD patients, mild subtype cases and controls were compared based on principal coordinate 1 and 2. (<b>b</b>) Boxplot comparing principal coordinate 1 between case and control samples. (<b>c</b>) Boxplot comparing principal coordinate 1 for severe subtype and mild subtype COPD patients and control samples. P-values were computed based on two-sided Wilcoxon-Mann-Whitney tests after correction for confounding effects from samples processed during winter or summer, respectively.</p

Clinical, spirometry and laboratory comparisons of patients and controls.

<p>Data presented as mean ±SD, unless otherwise indicated. Abbreviations: av. last cigarette (years): average years study participants stopped smoking before bronchoscopy procedure. BMI: body mass index. pO₂: partial pressure of oxygen. pCO₂: partial pressure of carbon dioxide. FEV₁: forced expiratory volume in 1s. FVC: forced vital capacity. LABA: long-acting beta-2 agonists.</p