3,891 research outputs found
Quantitative magnetisation transfer imaging in relapsing-remitting multiple sclerosis: a systematic review and meta-analysis
Myelin-sensitive MRI such as magnetization transfer imaging has been widely used in multiple sclerosis. The influence of methodology and differences in disease subtype on imaging findings is, however, not well established. Here, we systematically review magnetization transfer brain imaging findings in relapsing-remitting multiple sclerosis. We examine how methodological differences, disease effects and their interaction influence magnetization transfer imaging measures. Articles published before 06/01/2021 were retrieved from online databases (PubMed, EMBASE and Web of Science) with search terms including âmagnetization transferâ and âbrainâ for systematic review, according to a pre-defined protocol. Only studies that used human in vivo quantitative magnetization transfer imaging in adults with relapsing-remitting multiple sclerosis (with or without healthy controls) were included. Additional data from relapsing-remitting multiple sclerosis subjects acquired in other studies comprising mixed disease subtypes were included in meta-analyses. Data including sample size, MRI acquisition protocol parameters, treatments and clinical findings were extracted and qualitatively synthesized. Where possible, effect sizes were calculated for meta-analyses to determine magnetization transfer (i) differences between patients and healthy controls; (ii) longitudinal change and (iii) relationships with clinical disability in relapsing-remitting multiple sclerosis. Eighty-six studies met inclusion criteria. MRI acquisition parameters varied widely, and were also underreported. The majority of studies examined the magnetization transfer ratio in white matter, but magnetization transfer metrics, brain regions examined and results were heterogeneous. The analysis demonstrated a risk of bias due to selective reporting and small sample sizes. The pooled random-effects meta-analysis across all brain compartments revealed magnetization transfer ratio was 1.17 per cent units (95% CI â1.42 to â0.91) lower in relapsing-remitting multiple sclerosis than healthy controls (z-value: â8.99, P < 0.001, 46 studies). Linear mixed-model analysis did not show a significant longitudinal change in magnetization transfer ratio across all brain regions [β = 0.12 (â0.56 to 0.80), t-value = 0.35, P = 0.724, 14 studies] or normal-appearing white matter alone [β = 0.037 (â0.14 to 0.22), t-value = 0.41, P = 0.68, eight studies]. There was a significant negative association between the magnetization transfer ratio and clinical disability, as assessed by the Expanded Disability Status Scale [r = â0.32 (95% CI â0.46 to â0.17); z-value = â4.33, P < 0.001, 13 studies]. Evidence suggests that magnetization transfer imaging metrics are sensitive to pathological brain changes in relapsing-remitting multiple sclerosis, although effect sizes were small in comparison to inter-study variability. Recommendations include: better harmonized magnetization transfer acquisition protocols with detailed methodological reporting standards; larger, well-phenotyped cohorts, including healthy controls; and, further exploration of techniques such as magnetization transfer saturation or inhomogeneous magnetization transfer ratio
Predicting Strength of Matched Sets of Test Specimens
Five different methods for a priori estimating bending strength of wood and wood composite specimens are compared in this paper. They are: (1) edge-matching, (2) matching specimens by normal distribution, (3) matching specimens by log-normal distribution, (4) simple linear regression, and (5) multiple linear regression. It was found that the square root of mean square error (RMSE) of percent difference (PD) of predicted modulus of rupture (MOR) is the key measure in comparing the five methods. Multiple linear regression was found to be the best method to predict MOR of a specimen in an edge-matched set. Finally, how to create the prediction limits for mean MOR of a subgroup of specimens is discussed. The prediction limits for predicting MOR make it possible to quantitatively determine the effect of various treatments of wood materials
From heaviness to lightness during inflation
We study the quantum fluctuations of scalar fields with a variable effective
mass during an inflationary phase. We consider the situation where the
effective mass depends on a background scalar field, which evolves during
inflation from being frozen into a damped oscillatory phase when the Hubble
parameter decreases below its mass. We find power spectra with suppressed
amplitude on large scales, similar to the standard massless spectrum on small
scales, and affected by modulations on intermediate scales. We stress the
analogies and differences with the parametric resonance in the preheating
scenario. We also discuss some potentially observable consequences when the
scalar field behaves like a curvaton.Comment: 23 pages; 8 figures; published versio
Enhancement of the Nernst effect by stripe order in a high-Tc superconductor
The Nernst effect in metals is highly sensitive to two kinds of phase
transition: superconductivity and density-wave order. The large positive Nernst
signal observed in hole-doped high-Tc superconductors above their transition
temperature Tc has so far been attributed to fluctuating superconductivity.
Here we show that in some of these materials the large Nernst signal is in fact
caused by stripe order, a form of spin / charge modulation which causes a
reconstruction of the Fermi surface. In LSCO doped with Nd or Eu, the onset of
stripe order causes the Nernst signal to go from small and negative to large
and positive, as revealed either by lowering the hole concentration across the
quantum critical point in Nd-LSCO, or lowering the temperature across the
ordering temperature in Eu-LSCO. In the latter case, two separate peaks are
resolved, respectively associated with the onset of stripe order at high
temperature and superconductivity near Tc. This sensitivity to Fermi-surface
reconstruction makes the Nernst effect a promising probe of broken symmetry in
high-Tc superconductors
Using âwarm handoffsâ to link hospitalized smokers with tobacco treatment after discharge: study protocol of a randomized controlled trial
Post-discharge support is a key component of effective treatment for hospitalized smokers, but few hospitals provide it. Many hospitals and care settings fax-refer smokers to quitlines for follow-up; however, less than half of fax-referred smokers are successfully contacted and enrolled in quitline services. âWarm handoffâ is a novel approach to care transitions in which health care providers directly link patients with substance abuse problems with specialists, using face-to-face or phone transfer. Warm handoff achieves very high rates of treatment enrollment for these vulnerable groups
Using "warm handoffs" to link hospitalized smokers with tobacco treatment after discharge: Study protocol of a randomized controlled trial
Abstract
Background
Post-discharge support is a key component of effective treatment for hospitalized smokers, but few hospitals provide it. Many hospitals and care settings fax-refer smokers to quitlines for follow-up; however, less than half of fax-referred smokers are successfully contacted and enrolled in quitline services. “Warm handoff” is a novel approach to care transitions in which health care providers directly link patients with substance abuse problems with specialists, using face-to-face or phone transfer. Warm handoff achieves very high rates of treatment enrollment for these vulnerable groups.
Methods
The aim of this study—“EQUIP” (Enhancing Quitline Utilization among In-Patients)—is to determine the effectiveness, and cost-effectiveness, of warm handoff versus fax referral for linking hospitalized smokers with tobacco quitlines. This study employs a two-arm, individually randomized design. It is set in two large Kansas hospitals that have dedicated tobacco treatment interventionists on staff. At each site, smokers who wish to remain abstinent after discharge will be randomly assigned to groups. For patients in the fax group, staff will provide standard in-hospital intervention and will fax-refer patients to the state tobacco quitline for counseling post-discharge. For patients in the warm handoff group, staff will provide brief in-hospital intervention and immediate warm handoff: staff will call the state quitline, notify them that a warm handoff inpatient from Kansas is on the line, then transfer the call to the patients’ mobile or bedside hospital phone for quitline enrollment and an initial counseling session. Following the quitline session, hospital staff provides a brief check-back visit. Outcome measures will be assessed at 1, 6, and 12 months post enrollment. Costs are measured to support cost-effectiveness analyses. We hypothesize that warm handoff, compared to fax referral, will improve care transitions for tobacco treatment, enroll more participants in quitline services, and lead to higher quit rates. We also hypothesize that warm handoff will be more cost-effective from a societal perspective.
Discussion
If successful, this project offers a low-cost solution for more efficiently linking millions of hospitalized smokers with effective outpatient treatment—smokers that might otherwise be lost in the transition to outpatient care.
Trial registration
Clinical Trials Registration NCT01305928Peer Reviewe
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