Empirically Grounded Clinical Interventions Clients' and Referrers' Perceptions of Computer-Guided CBT (FearFighter)

Background: Computer-guided CBT has been shown to be a potentially useful Way of closing the gap between the demand and supply for CBT. Moreover, this approach has additional benefits in terms of less travel times for treatment, accessibility in remote and Unusual locations, increased confidentiality, easier disclosure of sensitive information, and more egalitarian therapist-client interactions. Research oil computerized CBT has concentrated Oil Clinical Outcomes. but the views Of clients oil this treatment approach have been relatively neglected. Aims: The aims were to assess client satisfaction, professionals' views, and ease of programme use after completion of treatment via ail internet-based CBT programme for panic and phobic anxiety (FearFighter). Method: A feasibility and effectiveness Study of FearFighter was conducted in remote and rural areas of Scotland. Treatment data are available for 35 clients at post-treatment, of whom 29 completed an I 8-item set of rating scales designed to assess satisfaction, including ease of use, accessibility. how far needs were met, whether changes to the programme were required, the benefits and drawbacks of not having a therapist, and quality of support. Open-ended questions were included. Referring agencies were also asked to rate their views on FearFighter. Results: Clients reported moderate to high levels of improvement and of overall satisfaction; very few difficulties in logging on to and using the programme were encountered. Similar levels of satisfaction with the programme were reported by referrers. Conclusions: It is concluded that computer-guided CBT is acceptable to clients and to professionals, and that it could play a valuable part in a "stepped care" system of delivering CBT.</p

Computational study of the hydrodefluorination of fluoroarenes at [Ru(NHC)(PR₃)<sub style="vertical-align: sub;">2</sub>(CO)(H)<sub style="vertical-align: sub;">2</sub>]: predicted scope and regioselectivities

Density functional theory calculations have been employed to investigate the scope and selectivity of the hydrodefluorination (HDF) of fluoroarenes, C6F6-nHn (n = 0-5), at catalysts of the type [Ru(NHC)(PR3)(2)(CO)(H)(2)]. Based on our previous study (Angew. Chem., Int. Ed., 2011, 50, 2783) two mechanisms featuring the nucleophilic attack of a hydride ligand at a fluoroarene substrate were considered: (i) a concerted process with Ru-H/C-F exchange occurring in one step; and (ii) a stepwise pathway in which the rate-determining transition state involves formation of HF and a Ru-sigma-fluoroaryl complex. The nature of the metal coordination environment and, in particular, the NHC ligand was found to play an important role in both promoting the HDF reaction and determining the regioselectivity of this process. Thus for the reaction of C6F5H, the full experimental system (NHC = IMes, R = Ph) promotes HDF through (i) more facile initial PR3/fluoroarene substitution and (ii) the ability of the NHC N-aryl substituents to stabilise the key C-F bond breaking transition state through F center dot center dot center dot HC interactions. This latter effect is maximised along the lower energy stepwise pathway when an ortho-H substituent is present and this accounts for the ortho-selectivity seen in the reaction of C6F5H to give 1,2,3,4-C6F4H2. Computed C-F bond dissociation energies (BDEs) for C6F6-nHn substrates show a general increase with larger n and are most sensitive to the number of ortho-F substituents present. However, HDF is always computed to remain significantly exothermic when a silane such as Me3SiH is included as terminal reductant. Computed barriers to HDF also generally increase with greater n, and for the concerted pathway a good correlation between C-F BDE and barrier height is seen. The two mechanisms were found to have complementary regioselectivities. For the concerted pathway the reaction is directed to sites with two ortho-F substituents, as these have the weakest C-F bonds. In contrast, reaction along the stepwise pathway is directed to sites with only one ortho-F substituent, due to difficulties in accommodating ortho-F substituents in the C-F bond cleavage transition state. Calculations predict that 1,2,3,5-C6F4H2 and 1,2,3,4-C6F4H2 are viable candidates for HDF at [Ru(IMes)(PPh3)(2)(CO)(H)(2)] and that this would proceed selectively to give 1,2,4-C6F3H3 and 1,2,3-C6F3H3, respectively.</p

EC scientist in UN poverty project

Award-winning Grahamstown professor Tebello Nyokong is reaching for the stars after she was appointed to a prestigious United Nations panel tasked with using science to reduce world poverty

Tourism can also play a vital role

Commissioned by the Eastern Cape Gambling and Betting Board (ECGBB), the Status of Traditional Horse Racing in the Eastern Cape report provides a fascinating glimpse into the long-lasting and often little known connection many Xhosa people have with horses. A cornerstone of rural Xhosa life, horses have been used for generations for work and transport - as well as racing

Combined experimental and computational investigations of rhodium-catalysed C-H functionalisation of pyrazoles with alkenes

Detailed experimental and computational studies have been carried out on the oxidative coupling of the alkenes C(2)H(3)Y (Y=CO(2)Me (a), Ph (b), C(O)Me (c)) with 3-aryl-5-R-pyrazoles (R=Me (1 a), Ph (1 b), CF(3) (1 c)) using a [Rh(MeCN)(3)Cp*][PF(6)](2)/Cu(OAc)(2)⋅H(2)O catalyst system. In the reaction of methyl acrylate with 1 a, up to five products (2 aa–6 aa) were formed, including the trans monovinyl product, either complexed within a novel Cu(I) dimer (2 aa) or as the free species (3 aa), and a divinyl species (6 aa); both 3 aa and 6 aa underwent cyclisation by an aza-Michael reaction to give fused heterocycles 4 aa and 5 aa, respectively. With styrene, only trans mono- and divinylation products were observed, whereas with methyl vinyl ketone, a stronger Michael acceptor, only cyclised oxidative coupling products were formed. Density functional theory calculations were performed to characterise the different migratory insertion and β-H transfer steps implicated in the reactions of 1 a with methyl acrylate and styrene. The calculations showed a clear kinetic preference for 2,1-insertion and the formation of trans vinyl products, consistent with the experimental results

Secular and Liminal: Discovering Heterogeneity among Religious Nones

This study examines the stability of religious preference among people who claim no religious preference in national surveys (i.e., religious nones). Using data from the Faith Matters Study, General Social Survey, and American National Election Study, we show that about 30 percent of religious nones in the first wave of the survey claim an affiliation with a religious group a year later. The percentage of religious nones remained stable in the two waves because a similar number of respondents moved in the opposite direction. Using various measures of religiosity, we show that most of these unstable nones report no significant change in religious belief or practice. We call them liminal nones as they stand halfway in and halfway out of a religious identity. We conclude by discussing the implications of our findings on the controversies surrounding the rise of religious nones in recent years

ALMA Observations of the Debris Disk of Solar Analogue Tau Ceti

We present 1.3 mm observations of the Sun-like star $\tau$ Ceti with the Atacama Large Millimeter/submillimeter Array (ALMA) that probe angular scales of $\sim1$'' (4 AU). This first interferometric image of the $\tau$ Ceti system, which hosts both a debris disk and possible multiplanet system, shows emission from a nearly face-on belt of cold dust with a position angle of $90^\circ$ surrounding an unresolved central source at the stellar position. To characterize this emission structure, we fit parametric models to the millimeter visibilities. The resulting best-fit model yields an inner belt edge of $6.2^{+9.8}_{-4.6}$ AU, consistent with inferences from lower resolution, far-infrared Herschel observations. While the limited data at sufficiently short baselines preclude us from placing stronger constraints on the belt properties and its relation to the proposed five planet system, the observations do provide a strong lower limit on the fractional width of the belt, $\Delta R/R > 0.75$ with $99\%$ confidence. This fractional width is more similar to broad disks such as HD 107146 than narrow belts such as the Kuiper Belt and Fomalhaut. The unresolved central source has a higher flux density than the predicted flux of the stellar photosphere at 1.3 mm. Given previous measurements of an excess by a factor of $\sim2$ at 8.7 mm, this emission is likely due to a hot stellar chromosphere.Comment: 18 pages, 6 figure

Convective infux/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the "glymphatic system" that proposes tracers enter the brain along periarterial "spaces" and leave the brain along the walls of veins. The object of the present study is to test the hypothesis that: (1) tracers from the CSF enter the cerebral cortex along pial-glial basement membranes as there are no perivascular "spaces" around cortical arteries, (2) tracers leave the brain along smooth muscle cell basement membranes that form the Intramural Peri-Arterial Drainage (IPAD) pathways for the elimination of interstitial fluid and solutes from the brain. 2 μL of 100 μM soluble, fluorescent fixable amyloid β (Aβ) were injected into the CSF of the cisterna magna of 6-10 and 24-30 month-old male mice and their brains were examined 5 and 30 min later. At 5 min, immunocytochemistry and confocal microscopy revealed Aβ on the outer aspects of cortical arteries colocalized with α-2 laminin in the pial-glial basement membranes. At 30 min, Aβ was colocalised with collagen IV in smooth muscle cell basement membranes in the walls of cortical arteries corresponding to the IPAD pathways. No evidence for drainage along the walls of veins was found. Measurements of the depth of penetration of tracer were taken from 11 regions of the brain. Maximum depths of penetration of tracer into the brain were achieved in the pons and caudoputamen. Conclusions drawn from the present study are that tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways. The exit route is along IPAD pathways in which Aβ accumulates in cerebral amyloid angiopathy (CAA) in Alzheimer's disease. Results from this study suggest that CSF may be a suitable route for delivery of therapies for neurological diseases, including CAA