Cooperation on Competition: The Multistate Tax Commission and State Corporate Tax Uniformity

This report explores how interstate uniformity of state corporate income taxes has varied over time, the role played by the MTC, and how likely it is that uniformity will be achieved. FRC Report 11

Brain GABA and Glutamate Concentrations Following Chronic Gabapentin Administration: A Convenience Sample Studied During Early Abstinence From Alcohol.

Gabapentin (GBP), a GABA analog that may also affect glutamate (Glu) production, can normalize GABA and Glu tone during early abstinence from alcohol, effectively treating withdrawal symptoms and facilitating recovery. Using in vivo magnetic resonance spectroscopy, we tested the degree to which daily GBP alters regional brain GABA and Glu levels in short-term abstinent alcohol-dependent individuals. Regional metabolite levels were compared between 13 recently abstinent alcohol-dependent individuals who had received daily GBP for at least 1 week (GBP+) and 25 matched alcohol-dependent individuals who had not received GBP (GBP-). Magnetic resonance spectra from up to five different brain regions were analyzed to yield absolute GABA and Glu concentrations. GABA and Glu concentrations in the parieto-occipital cortex were not different between GBP- and GBP+. Glu levels in anterior cingulate cortex, dorsolateral prefrontal cortex, and basal ganglia did not differ between GBP- and GBP+. However, in a subgroup of individuals matched on age, sex, and abstinence duration, GBP+ had markedly lower Glu in the frontal white matter (WM) than GBP-, comparable to concentrations found in light/non-drinking controls. Furthermore, lower frontal WM Glu in GBP+ correlated with a higher daily GBP dose. Daily GBP treatment at an average of 1,600 mg/day for at least 1 week was not associated with altered cortical GABA and Glu concentrations during short-term abstinence from alcohol, but with lower Glu in frontal WM. GBP for the treatment of alcohol dependence may work through reducing Glu in WM rather than increasing cortical GABA

Stochastic Gene Expression in Single Gene Oscillator Variants

It is infeasible to understand all dynamics in cell, but we can aim to understand the impact of design choices under our control. Here we consider a single gene oscillator as a case study to understand the influence of DNA copy number and repressor choice on the resulting dynamics. We first switch the repressor in the oscillator from the originally published lacI to treRL, a chimeric repressor with a lacI DNA binding domain that is inducible by trehalose. This slightly modified system produces faster and more regular oscillations than the original lacI oscillator. We then compare the treRL oscillator at three different DNA copy numbers. The period and amplitude of oscillations increases as the copy number is decreased. We cannot explain the change in period with differential equation models without changing delays or degradation rates. The correlation and phase coherence between daughter cells after cell division also tend to fall off faster for the lower copy oscillator variants. These results suggest that lower copy number variants of our single gene oscillator produce more synchronized oscillations

Leadership in Student Distance Education Teams

Interactive video technology has become a widely used medium for education. A prominent implementation of this technology, interactive distance learning, involves groups of students at local and remote sites connected by audio and video teleconferencing. This approach has made the task of delivering vital undergraduate and graduate engineering courses to distributed audiences much easier. As this approach has permeated more curricula, distance education instructors have increasingly assigned projects that require distance learners to work together as an element of the final course grade. This trend presents an interesting opportunity for researchers to understand the nature of interactions among course participants involved in project teams. This paper presents the results of an investigation of project leadership behaviors in the distance learning environment. Surveys were administered via online protocol to fifty-three students, comprising nineteen project teams. Results indicate that those teams led by individuals who clarified roles and task requirements, and recognized the strengths and individual needs of teams members performed better on their assigned tasks. Implications for instructors utilizing project teams in distance education, as well as traditional teams where communication technology (e.g., email) is highly relied upon, are presented

Direct constraints on the dark matter self-interaction cross-section from the merging galaxy cluster 1E0657-56

We compare new maps of the hot gas, dark matter, and galaxies for 1E0657-56, a cluster with a rare, high-velocity merger occurring nearly in the plane of the sky. The X-ray observations reveal a bullet-like gas subcluster just exiting the collision site. A prominent bow shock gives an estimate of the subcluster velocity, 4500 km/s, which lies mostly in the plane of the sky. The optical image shows that the gas lags behind the subcluster galaxies. The weak-lensing mass map reveals a dark matter clump lying ahead of the collisional gas bullet, but coincident with the effectively collisionless galaxies. From these observations, one can directly estimate the cross-section of the dark matter self-interaction. That the dark matter is not fluid-like is seen directly in the X-ray -- lensing mass overlay; more quantitative limits can be derived from three simple independent arguments. The most sensitive constraint, sigma/m<1 cm^2/g, comes from the consistency of the subcluster mass-to-light ratio with the main cluster (and universal) value, which rules out a significant mass loss due to dark matter particle collisions. This limit excludes most of the 0.5-5 cm^2/g interval proposed to explain the flat mass profiles in galaxies. Our result is only an order-of-magnitude estimate which involves a number of simplifying, but always conservative, assumptions; stronger constraints may be derived using hydrodynamic simulations of this cluster.Comment: Text clarified; some numbers changed slightly for consistency with final version of the accompanying lensing paper. 6 pages, uses emulateapj. ApJ in pres

A modified Oster-Murray-Harris mechanical model of morphogenesis

There are two main modeling paradigms for biological pattern formation in developmental biology: chemical prepattern models and cell aggregation models. This paper focuses on an example of a cell aggregation model, the mechanical model developed by Oster, Murray, and Harris [Development, 78 (1983), pp. 83--125]. We revisit the Oster--Murray--Harris model and find that, due to the infinitesimal displacement assumption made in the original version of this model, there is a restriction on the types of boundary conditions that can be prescribed. We derive a modified form of the model which relaxes the infinitesimal displacement assumption. We analyze the dynamics of this model using linear and multiscale nonlinear analysis and show that it has the same linear behavior as the original Oster--Murray--Harris model. Nonlinear analysis, however, predicts that the modified model will allow for a wider range of parameters where the solution evolves to a bounded steady state. The results from both analyses are verified through numerical simulations of the full nonlinear model in one and two dimensions. The increased range of boundary conditions that are well-posed, as well as a wider range of parameters that yield bounded steady states, renders the modified model more applicable to, and more robust for, comparisons with experiments