Slab Window Migration and Terrane Accretion Preserved by Low‐Temperature Thermochronology of a Magmatic Arc, Northern Antarctic Peninsula

Existing paleogeographic reconstructions indicate that the northern Antarctic Peninsula was central to several Mesozoic and Cenozoic tectonic events that have implications for ocean circulation and continental margin evolution. To evaluate the exhumational record of these processes, we collected new samples and measured fission track and (U‐Th)/He cooling ages of apatite and zircon from 13 Jurassic and Cretaceous granitoids in western Graham Land between the northern tip of the peninsula and the Antarctic Circle. Apatite He data reveal distinct ages and systematic age patterns north and south of Anvers Island, near the midpoint of the study area: To the south, apatite He ages range from 16 to 8 Ma and young northward, whereas to the north they range between 65 and 24 Ma (with one exception at 11 Ma) and young southward. Thermal histories inferred from the ages and closure temperatures of multiple thermochronometers in single samples indicate distinct histories for northern and southern Graham Land. Northern sites reveal a Late Cretaceous pulse of rapid cooling (\u3e7°C/Myr) followed by very slow cooling (∼1°C/Myr) to the Recent, whereas southern sites record either a pulse of rapid mid‐Miocene cooling (∼8°C/Myr) or steady and moderate cooling (∼3°C/Myr) from the Late Cretaceous to the Recent. We interpret the Late Cretaceous rapid cooling in the northern part of the study area as a possible manifestation of terrane accretion associated with the Palmer Land event. We interpret the systematic spatial trends in apatite He ages and contrasting thermal histories along the peninsula as recording progressive Late Cenozoic northward opening of a slab window south of Anvers Island. This is consistent with a time transgressive pulse of ∼2–3 km of rock uplift and exhumation in the upper plate following ridge‐trench collision, cessation of subduction, and opening of the slab window, presumably caused by increased asthenospheric upwelling beneath the overriding plate

Application of Foreland Basin Detrital-Zircon Geochronology to the Reconstruction of the Southern and Central Appalachian Orogen

We report the U-Pb age distribution of detrital zircons collected from central and southern Appalachian foreland basin strata, which record changes of sediment provenance in response to the different phases of the Appalachian orogeny. Taconic clastic wedges have predominantly ca. 1080–1180 and ca. 1300–1500 Ma zircons, whereas Acadian clastic wedges contain abundant Paleozoic zircons and minor populations of 550–700 and 1900–2200 Ma zircons consistent with a Gondwanan affinity. Alleghanian clastic wedges contain large populations of ca. 980–1080 Ma and ca. 2700 Ma and older Archean zircons and fewer Paleozoic zircons than occur in the Acadian clastic wedges. The abundance of Paleozoic detrital zircons in Acadian clastic wedges indicates that the Acadian hinterland consisted of recycled material and Taconic-aged plutons, which provided significant detritus to the Acadian foreland basin. The appearance of Pan-African/Brasiliano- and Eburnean/Trans-Amazonian-aged zircons in Acadian clastic wedges suggests a Devonian accretion of the Carolina terrane. In contrast, the relative decrease in abundance of Paleozoic detrital zircons coupled with an increase of Archean and Grenville zircons in Alleghanian clastic wedges indicates the development of an orogenic hinterland consisting of deformed passive margin strata and Grenville basement. The younging-upward age progression in Grenville province sources revealed in Taconic through Alleghanian successions suggest a reverse unroofing sequence that indicates at least two cycles of Grenville zircon recycling

Detrital-Zircon Geochronology of the Metasedimentary Rocks of North-Western Graham Land

Metasedimentary rocks constitute an important but comparatively poorly understood part of the Antarctic Peninsula. Herein we report single-grain U-Pb detrital-zircon ages from samples of the Trinity Peninsula and Botany Bay Groups of north-western Graham Land. All studied samples are dominated by a large and narrowly defined population of late Palaeozoic zircons. Significant early–middle Palaeozoic and minor Neoproterozoic and Mesoproterozoic sub-populations constitute the majority of pre-Carboniferous grains. These detrital-zircon age populations are consistent with sediment derivation entirely from western Gondwana sources. Despite the clear Gondwana signatures, our data suggest that the Trinity Peninsula Group province was either a parautochthonous peri-Gondwanan terrane later accreted to the Antarctic Peninsula, or a significant topographic barrier precluded voluminous sediment contributions from the interior of Gondwana. Statistical comparisons with similar metasedimentary complexes of southern South America, the South Shetland Islands and eastern New Zealand indicate a diversity of sediment provenance not previously recognized, but may provide a means to better determine the pre-break-up configuration of western Gondwana. Although insufficient to definitively restore Antarctic Peninsula components adjacent to South American complexes, some Trinity Peninsula Group samples exhibit robust affinities to the Miers Bluff Formation in the South Shetland Islands and the Duque de York and Main Range Metamorphic Complexes of the Patagonian Andes

What makes primary care effective for people in poverty living with multiple chronic conditions?: study protocol

Abstract Background: The inverse care law persists: people living in poverty have the greatest needs and face considerable challenges in getting the care they need. Evidence reveals that GPs encounter difficulties in delivering care to poor patients, while many of those patients feel stigmatized by healthcare professionals. Patients living in poverty report negative healthcare experiences and unmet healthcare needs. Indeed, there is a growing recognition in primary care research of the importance of addressing the capabilities and social conditions of the poor when delivering care. Few studies have looked at the factors contributing to effective and "socially responsive" care for people living in poverty. Methods/Design: Our study adopts a qualitative ethnographic approach in four healthcare organizations in deprived areas of metropolitan Montreal (Québec, Canada), using patient shadowing techniques and interviews. Data will be collected through fieldwork observations and informal interviews with patients before and after consultations. We will observe medical consultations, care organization activities, and waiting areas and reception of patients. We will conduct a total of 36 individual interviews with 12 GPs and 24 patients. The interviews will be audio-recorded and transcribed for purposes of analysis. The analysis consists of debriefing sessions, coding and interpretive analysis. Discussion: This study aims to investigate how positive healthcare interactions between physicians and patients can improve the management of chronic conditions. We hypothesize that factors related to care organization, to healthcare professionals' experience and to patients may enhance the quality of healthcare interactions, which may have positive impacts for preventing and managing chronic conditions. Our study will provide a unique set of data grounded in the perspectives of healthcare professionals and of patients living in poverty

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote

The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology. Like other ciliates, this species has separate germline and soma functions that are embodied by distinct nuclei within a single cell. The germline-like micronucleus (MIC) has its genome held in reserve for sexual reproduction. The soma-like macronucleus (MAC), which possesses a genome processed from that of the MIC, is the center of gene expression and does not directly contribute DNA to sexual progeny. We report here the shotgun sequencing, assembly, and analysis of the MAC genome of T. thermophila, which is approximately 104 Mb in length and composed of approximately 225 chromosomes. Overall, the gene set is robust, with more than 27,000 predicted protein-coding genes, 15,000 of which have strong matches to genes in other organisms. The functional diversity encoded by these genes is substantial and reflects the complexity of processes required for a free-living, predatory, single-celled organism. This is highlighted by the abundance of lineage-specific duplications of genes with predicted roles in sensing and responding to environmental conditions (e.g., kinases), using diverse resources (e.g., proteases and transporters), and generating structural complexity (e.g., kinesins and dyneins). In contrast to the other lineages of alveolates (apicomplexans and dinoflagellates), no compelling evidence could be found for plastid-derived genes in the genome. UGA, the only T. thermophila stop codon, is used in some genes to encode selenocysteine, thus making this organism the first known with the potential to translate all 64 codons in nuclear genes into amino acids. We present genomic evidence supporting the hypothesis that the excision of DNA from the MIC to generate the MAC specifically targets foreign DNA as a form of genome self-defense. The combination of the genome sequence, the functional diversity encoded therein, and the presence of some pathways missing from other model organisms makes T. thermophila an ideal model for functional genomic studies to address biological, biomedical, and biotechnological questions of fundamental importance

Protocol of a randomized controlled trial of the Tobacco Tactics website for operating engineers

<p>Abstract</p> <p>Background</p> <p>Recent research indicates that 35 percent of blue-collar workers in the US currently smoke while only 20 percent of white-collar workers smoke. Over the last year, we have been working with heavy equipment operators, specifically the Local 324 Training Center of the International Union of Operating Engineers, to study the epidemiology of smoking, which is 29% compared to 21% among the general population. For the current study funded by the National Cancer Institute (1R21CA152247-01A1), we have developed the Tobacco Tactics website which will be compared to the state supported 1-800-QUIT-NOW telephone line. Outcome evaluation will compare those randomized to the Tobacco Tactics web-based intervention to those randomized to the 1-800-QUIT-NOW control condition on: a) 30-day and 6-month quit rates; b) cotinine levels; c) cigarettes smoked/day; d) number of quit attempts; and e) nicotine addiction. Process evaluation will compare the two groups on the: a) contacts with intervention; b) medications used; c) helpfulness of the nurse/coach; and d) willingness to recommend the intervention to others.</p> <p>Methods/Design</p> <p>This will be a randomized controlled trial (N = 184). Both interventions will be offered during regularly scheduled safety training at Local 324 Training Center of the International Union of Operating Engineers and both will include optional provision of over-the-counter nicotine replacement therapy and the same number of telephone contacts. However, the Tobacco Tactics website has graphics tailored to Operating Engineers, tailored cessation feedback from the website, and follow up nurse counseling offered by multimedia options including phone and/or email, and/or e-community. Primary Analysis of Aim 1 will be conducted by using logistic regression to compare smoking habits (e.g., quit rates) of those in the intervention arm to those in the control arm. Primary analyses for Aim 2 will compare process measures (e.g., medications used) between the two groups by linear, logistic, and Poisson regression.</p> <p>Discussion</p> <p>Dissemination of an efficacious work-site, web-based smoking cessation intervention has the potential to substantially impact cancer rates among this population. Based on the outcome of this smaller study, wider scale testing in conjunction with the International Environment Technology Testing Center which services Operating Engineers across North America (including US, Mexico, and Canada) will be conducted.</p> <p>Trial registration</p> <p>NCT01124110</p

Mourning and melancholia revisited: correspondences between principles of Freudian metapsychology and empirical findings in neuropsychiatry

Freud began his career as a neurologist studying the anatomy and physiology of the nervous system, but it was his later work in psychology that would secure his place in history. This paper draws attention to consistencies between physiological processes identified by modern clinical research and psychological processes described by Freud, with a special emphasis on his famous paper on depression entitled 'Mourning and melancholia'. Inspired by neuroimaging findings in depression and deep brain stimulation for treatment resistant depression, some preliminary physiological correlates are proposed for a number of key psychoanalytic processes. Specifically, activation of the subgenual cingulate is discussed in relation to repression and the default mode network is discussed in relation to the ego. If these correlates are found to be reliable, this may have implications for the manner in which psychoanalysis is viewed by the wider psychological and psychiatric communities