Enabling III-V-based optoelectronics with low-cost dynamic hydride vapor phase epitaxy

Silicon is the dominant semiconductor in many semiconductor device applications for a variety of reasons, including both performance and cost. III-V materials have improved performance compared to silicon, but currently they are relegated to applications in high-value or niche markets due to the absence of a low-cost, high-quality production technique. Here we present an advance in III-V materials synthesis using hydride vapor phase epitaxy that has the potential to lower III-V semiconductor deposition costs by orders of magnitude while maintaining the requisite optoelectronic material quality that enables III-V-based technologies to outperform Si. We demonstrate the impacts of this advance by addressing the use of III-Vs in terrestrial photovoltaics, a highly cost-constrained market. The emergence of a low-cost III-V deposition technique will enable III-V electronic and opto-electronic devices, with all the benefits that they bring, to permeate throughout modern society.Comment: pre-prin

A Bounded-Size Likelihood Test for Non- Nested Probabilistic Discrete Choice Models Estimated from Choice-Based Samples

Discrete-choice models of the hierarchical logit form enable the analyst to configure tree structures and to investigate the relative statistical and behavioural strengths of alternative hierarchies. The alternative tree structures can be nested or nonnested in a specification sense, and the underlying sample of observations can be exogenous or endogenous. When the sample is endogenous (i.e. choice based) and alternative tree structures are non-nested in a statistically comparative sense, the conventional likelihood ratio tests for comparisons of exogenously sampled nested hierarchical models are not appropriate. This paper presents a bounded-size likelihood ratio test for non-nested discrete choice models estimated from choice-based samples. The tests are presented with and without correction for sample size. We apply the test using a sample of four transport modes for long distance non-business travel in Australia

Timing Robustness in the Budding and Fission Yeast Cell Cycles

Robustness of biological models has emerged as an important principle in systems biology. Many past analyses of Boolean models update all pending changes in signals simultaneously (i.e., synchronously), making it impossible to consider robustness to variations in timing that result from noise and different environmental conditions. We checked previously published mathematical models of the cell cycles of budding and fission yeast for robustness to timing variations by constructing Boolean models and analyzing them using model-checking software for the property of speed independence. Surprisingly, the models are nearly, but not totally, speed-independent. In some cases, examination of timing problems discovered in the analysis exposes apparent inaccuracies in the model. Biologically justified revisions to the model eliminate the timing problems. Furthermore, in silico random mutations in the regulatory interactions of a speed-independent Boolean model are shown to be unlikely to preserve speed independence, even in models that are otherwise functional, providing evidence for selection pressure to maintain timing robustness. Multiple cell cycle models exhibit strong robustness to timing variation, apparently due to evolutionary pressure. Thus, timing robustness can be a basis for generating testable hypotheses and can focus attention on aspects of a model that may need refinement

Plane waves with weak singularities

We study a class of time dependent solutions of the vacuum Einstein equations which are plane waves with weak null singularities. This singularity is weak in the sense that though the tidal forces diverge at the singularity, the rate of divergence is such that the distortion suffered by a freely falling observer remains finite. Among such weak singular plane waves there is a sub-class which do not exhibit large back reaction in the presence of test scalar probes. String propagation in these backgrounds is smooth and there is a natural way to continue the metric beyond the singularity. This continued metric admits string propagation without the string becoming infinitely excited. We construct a one parameter family of smooth metrics which are at a finite distance in the space of metrics from the extended metric and a well defined operator in the string sigma model which resolves the singularity.Comment: 22 pages, Added references and clarifying comment

Computing and data processing

The applications of computers and data processing to astronomy are discussed. Among the topics covered are the emerging national information infrastructure, workstations and supercomputers, supertelescopes, digital astronomy, astrophysics in a numerical laboratory, community software, archiving of ground-based observations, dynamical simulations of complex systems, plasma astrophysics, and the remote control of fourth dimension supercomputers

Intestinal fibrosis is reduced by early elimination of inflammation in a mouse model of IBD: Impact of a “Top‐Down” approach to intestinal fibrosis in mice

Background: The natural history of Crohn's disease follows a path of progression from an inflammatory to a fibrostenosing disease, with most patients requiring surgical resection of fibrotic strictures. Potent antiinflammatory therapies reduce inflammation but do not appear to alter the natural history of intestinal fibrosis. The aim of this study was to determine the relationship between intestinal inflammation and fibrogenesis and the impact of a very early “top‐down” interventional approach on fibrosis in vivo. Methods: In this study we removed the inflammatory stimulus from the Salmonella typhimurium mouse model of intestinal fibrosis by eradicating the S. typhimurium infection with levofloxacin at sequential timepoints during the infection. We evaluated the effect of this elimination of the inflammatory stimulus on the natural history of inflammation and fibrosis as determined by gross pathology, histopathology, mRNA expression, and protein expression. Results: Fibrogenesis is preceded by inflammation. Delayed eradication of the inflammatory stimulus by antibiotic treatment represses inflammation without preventing fibrosis. Early intervention significantly ameliorates but does not completely prevent subsequent fibrosis. Conclusions: This study demonstrates that intestinal fibrosis develops despite removal of an inflammatory stimulus and elimination of inflammation. Early intervention ameliorates but does not abolish subsequent fibrosis, suggesting that fibrosis, once initiated, is self‐propagating, suggesting that a very early top‐down interventional approach may have the most impact on fibrostenosing disease. (Inflamm Bowel Dis 2012;)Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90367/1/21812_ftp.pd

A Review of the External Validity of Clinical Trials with Beta-Blockers in Heart Failure

This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.Background: Beta-blockers (BBs) are the mainstay prognostic medication for all stages of chronic heart failure (CHF). There are many classes of BBs, each of which has varying levels of evidence to support its efficacy in CHF. However, most CHF patients have one or more comorbid conditions such as diabetes, renal impairment, and/or atrial fibrillation. Patient enrollment to randomized controlled trials (RCTs) often excludes those with certain comorbidities, particularly if the symptoms are severe. Consequently, the extent to which evidence drawn from RCTs is generalizable to CHF patients has not been well described. Clinical guidelines also underrepresent this point by providing generic advice for all patients. The aim of this review is to examine the evidence to support the use of BBs in CHF patients with common comorbid conditions. Methods: We searched MEDLINE, PubMed, and the reference lists of reviews for RCTs, post hoc analyses, systematic reviews, and meta-analyses that report on use of BBs in CHF along with patient demographics and comorbidities. Results: In total, 38 studies from 28 RCTs were identified, which provided data on six BBs against placebo or head to head with another BB agent in ischemic and nonischemic cardiomyopathies. Several studies explored BBs in older patients. Female patients and non-Caucasian race were underrepresented in trials. End points were cardiovascular hospitalization and mortality. Comorbid diabetes, renal impairment, or atrial fibrillation was detailed; however, no reference to disease spectrum or management goals as a focus could be seen in any of the studies. In this sense, enrollment may have limited more severe grades of these comorbidities. Conclusions: RCTs provide authoritative information for a spectrum of CHF presentations that support guidelines. RCTs may provide inadequate information for more heterogeneous CHF patient cohorts. Greater Phase IV research may be needed to fill this gap and inform guidelines for a more global patient population

Effect of vesical overdistention on bladder mucin

Histochemical staining of bladder tissue demonstrates a discrete layer of mucopolysaccharide (mucin) on the surface of human and rabbit bladders. Studies have shown that an intact mucin layer may be important in helping the bladder to resist bacterial infections. This report correlates vesical overdistention with destruction of the mucin layer in the rabbit bladder. These findings suggest that vesical overdistention may predispose to urinary tract infection because of bladder mucin disruption.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24244/1/0000507.pd

AdS/CFT and the Information Paradox

The information paradox in the quantum evolution of black holes is studied within the framework of the AdS/CFT correspondence. The unitarity of the CFT strongly suggests that all information about an initial state that forms a black hole is returned in the Hawking radiation. The CFT dynamics implies an information retention time of order the black hole lifetime. This fact determines many qualitative properties of the non-local effects that must show up in a semi-classical effective theory in the bulk. We argue that no violations of causality are apparent to local observers, but the semi-classical theory in the bulk duplicates degrees of freedom inside and outside the event horizon. Non-local quantum effects are required to eliminate this redundancy. This leads to a breakdown of the usual classical-quantum correspondence principle in Lorentzian black hole spacetimes.Comment: 16 pages, harvmac, reference added, minor correction

Charged Dilatonic AdS Black Branes in Arbitrary Dimensions

We study electromagnetically charged dilatonic black brane solutions in arbitrary dimensions with flat transverse spaces, that are asymptotically AdS. This class of solutions includes spacetimes which possess a bulk region where the metric is approximately invariant under Lifshitz scalings. Given fixed asymptotic boundary conditions, we analyze how the behavior of the bulk up to the horizon varies with the charges and derive the extremality conditions for these spacetimes.Comment: References update