The strategic evolution of Aer Lingus from a full-service airline to a low-cost carrier and finally positioning itself into a value hybrid airline

Aer Lingus has been an unique airline as it transitioned from a full-service airline to a low-cost carrier and is currently positioned as a value hybrid airline. It has coexisted with Ryanair for decades and it encountered three imminent periods where bankruptcy prevailed from 1993 to 2009. The research aims to uncover the various strategies that were applied to structurally re-engineer the carrier in order to adapt to its evolving competitive landscape. The key pillars underpinning Aer Lingus’ turnaround as a value hybrid were as follows: strict adherence to capacity discipline; relentless cost control and value-adding, consumer-driven product differentiation; innovative partnerships including contract flying to alleviate its problematic seasonality issues inherent in Aer Lingus markets; and by re-engineering its Dublin-based hub airport. A visionary master plan for the hub was fabricated to capitalize on Ireland’s geographical positioning which targeted the traffic flows between UK/European and North American destinations through its synchronized connection network at Dublin

On some inverse problems for a nonlinear transport equation

Inverse problems for nonlinear transport or one-way wave equation are considered. Analytic solutions to the inverse problems are given and it is shown, for some signalling problems, that the inverse problem of determination of a wavespeed functional is well-posed, and that the wavespeed can be uniquely determined. However, it is shown that· the inverse problems of reconstruction of a source functional are ill-posed, although the source is still uniquely determined

Dual Eligibles: Medicaid Enrollment and Spending for Medicare Beneficiaries in 2007

Provides an update on the share of total Medicaid enrollment and spending on those eligible for both Medicare and Medicaid through 2007, state-by-state estimates of Medicaid enrollment and expenditures for dual eligibles, and a breakdown of expenditures

Erratum: Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients

[No abstract available

Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients

Natural killer T (NKT) cells are distinct glycolipid reactive innate lymphocytes that are implicated in the resistance to pathogens and tumors. Earlier attempts to mobilize NKT cells, specifically, in vivo in humans met with limited success. Here, we evaluated intravenous injection of monocyte-derived mature DCs that were loaded with a synthetic NKT cell ligand, α-galactosyl-ceramide (α-GalCer; KRN-7000) in five patients who had advanced cancer. Injection of α-GalCer-pulsed, but not unpulsed, dendritic cells (DCs) led to \u3e100-fold expansion of several subsets of NKT cells in all patients; these could be detected for up to 6 mo after vaccination. NKT activation was associated with an increase in serum levels of interleukin-12 p40 and IFN-γ inducible protein-10. In addition, there was an increase in memory CD8+ T cells specific for cytomegalovirus in vivo in response to α-GalCer-loaded DCs, but not unpulsed DCs. These data demonstrate the feasibility of sustained expansion of NKT cells in vivo in humans, including patients who have advanced cancer, and suggest that NKT activation might help to boost adaptive T cell immunity in vivo

Presbyterian Imitation Practices in Zachary Boyd’s Nebuchadnezzars Fierie Furnace

The university administrator, preacher and poet Zachary Boyd (1585–1653) relied heavily on epithets and similes borrowed from Josuah Sylvester's poetry when composing his scriptural versifications Zion's Flowers(c. 1640?). The composition of Boyd's adaptation of Daniel 3, Nebuchadnezzars Fierie Furnace, provides an unusually lucid example of the reading and imitation practices of a mid-seventeenth-century Scottish Presbyterian in the years preceding civil war. This article begins by re-considering a manuscript transcription of Fierie Furnace held at the British Library previously described as an anonymous playtext from the early 1610s, then establishes the nature of Boyd's reliance on Sylvester by analyzing holograph manuscripts held at Glasgow University Library, a sermon Boyd wrote on the same theme, and the copy of Sylvester's Devine Weekes, and Workes that Boyd probably used.Arts and Humanities Research Counci

How reproductive allocation and flowering probability of individuals in plant populations are affected by position in stand size hierarchy, plant size and CO2 regime

We investigate the effect of position within a size-structured population on the reproductive allocation (RA) and flowering probability of individual plants of Sinapis arvensis. We also assess the effects of plant size and changing level of CO2 on both responses

Institutions ignored: a history of Select Committee scrutiny in the House of Lords, 1968-2021

Within the vast seam of scholarship on parliamentary history the evolution and role of select committees in the House of Lords, particularly in relation to investigatory or policy-focused committees, has been almost completely overlooked. They have been ‘institutions ignored’. This gap in the existing research base is particularly stark when compared with the very large literature on the history of select committees in the House of Commons. This article fills this gap by providing the first detailed historical account of the evolution of investigatory or policy-focused committees in the House of Lords. This account reveals the evolution of a distinctive ‘scrutiny style’ moulded around the notion of complementarity, a highly specialised approach and an understanding of the merits of self-restraint. However, during 2018-2021 a fundamental review of the investigatory committee system was undertaken within the House of Lords which led to significant change in relation to both the structure and ambition of committees. The impact of this reform agenda is likely to ensure that select committees in the Lords are far more visible in the future, within and beyond the Palace of Westminster, than they were in the past

PMP22 exon 4 deletion causes ER retention of PMP22 and a gain-of-function allele in CMT1E

OBJECTIVE: To determine whether predicted fork stalling and template switching (FoSTeS) during mitosis deletes exon 4 in peripheral myelin protein 22 KD (PMP22) and causes gain‐of‐function mutation associated with peripheral neuropathy in a family with Charcot–Marie–Tooth disease type 1E. METHODS: Two siblings previously reported to have genomic rearrangements predicted to involve exon 4 of PMP22 were evaluated clinically and by electrophysiology. Skin biopsies from the proband were studied by RT‐PCR to determine the effects of the exon 4 rearrangements on exon 4 mRNA expression in myelinating Schwann cells. Transient transfection studies with wild‐type and mutant PMP22 were performed in Cos7 and RT4 cells to determine the fate of the resultant mutant protein. RESULTS: Both affected siblings had a sensorimotor dysmyelinating neuropathy with severely slow nerve conduction velocities (<10 m/sec). RT‐PCR studies of Schwann cell RNA from one of the siblings demonstrated a complete in‐frame deletion of PMP22 exon 4 (PMP22Δ4). Transfection studies demonstrated that PMP22Δ4 protein is retained within the endoplasmic reticulum and not transported to the plasma membrane. CONCLUSIONS: Our results confirm that that FoSTeS‐mediated genomic rearrangement produced a deletion of exon 4 of PMP22, resulting in expression of both PMP22 mRNA and protein lacking this sequence. In addition, we provide experimental evidence for endoplasmic reticulum retention of the mutant protein suggesting a gain‐of‐function mutational mechanism consistent with the observed CMT1E in this family. PMP22Δ4 is another example of a mutated myelin protein that is misfolded and contributes to the pathogenesis of the neuropathy