Overview of Recent Flight Flutter Testing Research at NASA Dryden

In response to the concerns of the aeroelastic community, NASA Dryden Flight Research Center, Edwards, California, is conducting research into improving the flight flutter (including aeroservoelasticity) test process with more accurate and automated techniques for stability boundary prediction. The important elements of this effort so far include the following: (1) excitation mechanisms for enhanced vibration data to reduce uncertainty levels in stability estimates; (2) investigation of a variety of frequency, time, and wavelet analysis techniques for signal processing, stability estimation, and nonlinear identification; and (3) robust flutter boundary prediction to substantially reduce the test matrix for flutter clearance. These are critical research topics addressing the concerns of a recent AGARD Specialists' Meeting on Advanced Aeroservoelastic Testing and Data Analysis. This paper addresses these items using flight test data from the F/A-18 Systems Research Aircraft and the F/A-18 High Alpha Research Vehicle

A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: Approach

Mathematical models of radiation carcinogenesis are important for understanding mechanisms and for interpreting or extrapolating risk. There are two classes of such models: (1) long-term formalisms that track pre-malignant cell numbers throughout an entire lifetime but treat initial radiation dose–response simplistically and (2) short-term formalisms that provide a detailed initial dose–response even for complicated radiation protocols, but address its modulation during the subsequent cancer latency period only indirectly. We argue that integrating short- and long-term models is needed. As an example of this novel approach, we integrate a stochastic short-term initiation/inactivation/repopulation model with a deterministic two-stage long-term model. Within this new formalism, the following assumptions are implemented: radiation initiates, promotes, or kills pre-malignant cells; a pre-malignant cell generates a clone, which, if it survives, quickly reaches a size limitation; the clone subsequently grows more slowly and can eventually generate a malignant cell; the carcinogenic potential of pre-malignant cells decreases with age

A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation

As the number of cancer survivors grows, prediction of radiotherapy-induced second cancer risks becomes increasingly important. Because the latency period for solid tumors is long, the risks of recently introduced radiotherapy protocols are not yet directly measurable. In the accompanying article, we presented a new biologically based mathematical model, which, in principle, can estimate second cancer risks for any protocol. The novelty of the model is that it integrates, into a single formalism, mechanistic analyses of pre-malignant cell dynamics on two different time scales: short-term during radiotherapy and recovery; long-term during the entire life span. Here, we apply the model to nine solid cancer types (stomach, lung, colon, rectal, pancreatic, bladder, breast, central nervous system, and thyroid) using data on radiotherapy-induced second malignancies, on Japanese atomic bomb survivors, and on background US cancer incidence. Potentially, the model can be incorporated into radiotherapy treatment planning algorithms, adding second cancer risk as an optimization criterion

On-Line Loss of Control Detection Using Wavelets

Wavelet transforms are used for on-line detection of aircraft loss of control. Wavelet transforms are compared with Fourier transform methods and shown to more rapidly detect changes in the vehicle dynamics. This faster response is due to a time window that decreases in length as the frequency increases. New wavelets are defined that further decrease the detection time by skewing the shape of the envelope. The wavelets are used for power spectrum and transfer function estimation. Smoothing is used to tradeoff the variance of the estimate with detection time. Wavelets are also used as front-end to the eigensystem reconstruction algorithm. Stability metrics are estimated from the frequency response and models, and it is these metrics that are used for loss of control detection. A Matlab toolbox was developed for post-processing simulation and flight data using the wavelet analysis methods. A subset of these methods was implemented in real time and named the Loss of Control Analysis Tool Set or LOCATS. A manual control experiment was conducted using a hardware-in-the-loop simulator for a large transport aircraft, in which the real time performance of LOCATS was demonstrated. The next step is to use these wavelet analysis tools for flight test support

Hydrodynamic Coupling of Two Brownian Spheres to a Planar Surface

We describe direct imaging measurements of the collective and relative diffusion of two colloidal spheres near a flat plate. The bounding surface modifies the spheres' dynamics, even at separations of tens of radii. This behavior is captured by a stokeslet analysis of fluid flow driven by the spheres' and wall's no-slip boundary conditions. In particular, this analysis reveals surprising asymmetry in the normal modes for pair diffusion near a flat surface.Comment: 4 pages, 4 figure

Sustainable forest bioenergy development strategies in Indochina: Collaborative effort to establish regional policies

We conducted a feasibility study in Indochina (Cambodia, Laos, Myanmar, Thailand, and Vietnam) with the aim of promoting biomass and bioenergy markets, technology transfer, rural development, and income generation. Policy development is guided by the International Union of Forest Research Institutions (IUFRO) Task Force “Sustainable Forest Bioenergy Network”. In this paper, we highlight the achievements up to now and present results of a multi-stakeholder questionnaire in combination with a quantitative analysis of the National Bioenergy Development Plans (NBDPs). We found a gap between official documents and working group assessments. NBDPs are focused on the market development, technology transfer, and funding possibilities of a regional bioenergy strategy, while the respondents of a questionnaire (working groups) favored more altruistic goals, i.e., sustainable resource management, environmental protection and climate change mitigation, generation of rural income, and community involvement, etc. We therefore suggest the following measures to ensure regulations that support the original aims of the network (climate change mitigation, poverty alleviation, sustainable resource use, and diversification of energy generation): (i) Consideration of science-based evidence for drafting bioenergy policies, particularly in the field of biomass production and harvesting; (ii) invitation of stakeholders representing rural communities to participate in this process; (iii) development of sustainability criteria; (iv) feedback cycles ensuring more intensive discussion of policy drafts; (v) association of an international board of experts to provide scientifically sound feedback and input; and (vi) establishment of a local demonstration region, containing various steps in the biomass/bioenergy supply chain including transboundary collaboration in the ACMECS region

?? Special Feature THE DOSE-RATE EFFECT REVISITED: RADIOBIOLOGICAL CONSIDERATIONS OF IMPORTANCE IN RADIOTHERAPY

A wide range of dose-rates have been used in radiation biology and radiation therapy, extending from a few cGy per day to hundreds of Gy in a fraction of a second. The dose-rate range of importance in radiotherapy extends from about 0.1 Gy/br to several Gy/min. In tbis range, the fraction of cells billed by a given dose decreases as tbe dose-rate is reduced, principally because of the repair of sub-lethal damage. In some ceil lines, an inverse dose-rate effect is observed where, over a narrow range of dose-rates, the effectiveness of a given dose increases with decreasing dose-rate if cells move through tbe cycle and are arrested in G,, which is a radiosensitive phase. In recent years data have accumulated for cells of human origin. About 40 data sets have been analyzed for values of tbe survival curve parameters and the rate of repair of sub-lethal damage. These data have been used to address three questions of relevance to radiotherapy