Dopamine Autoreceptor Regulation of a Hypothalamic Dopaminergic Network

Acknowledgments The authors thank Drs. Gilberto Fisone, Jessica Ausborn, Abdel El Manira, Gilad Silberberg, and members of the C.B. laboratory for advice, as well as Paul Williams for expert help with the graphical abstract. This study was supported by a Starting Investigator Grant from the ERC (ENDOSWITCH 261286), the Swedish Research Council (2010-3250), Novo Nordisk Fonden, and the Strategic Research Programme in Diabetes at Karolinska Institutet.Peer reviewedPublisher PD

The Impact of Inventory Leanness and Slack Resources on Supply Chain Resilience: An Empirical Study

When a major disruption occurs, an organization’s performance is usually negatively affected. The great recession of 2008 – 2009 was such a disruption which had global implications that had not been seen since the great depression that started in the 1930s. This thesis is intended to contribute to the understanding of how leanness and slack resources affect firm performance in the presence of disruptions that test supply chain resilience, or the ability to restore the firm’s performance to its original condition after encountering stress or a large disturbance. These disruptions may not only affect the firm’s financial performance during the disruption but also well after the disruption has occurred. Two industries with differing supply chains, food and beverage, and electronics and computer, were investigated. The study is based on archival data (N=10,020 and 668 firms) with observations from just before and just after the great recession, a disruption that affected the entire global economy. Our results suggest (1) the effect of inventory leanness and slack resources on firm performance is industry specific; and (2) variation in firm performance is less in the post-disruptive period than in the pre-disrupted period. Overall, our findings call for a contingency perspective to specify the level of inventory leanness and slack resources when determining their impact on firm performance to support supply chain resilience

Ion radial diffusion in an electrostatic impulse model for stormtime ring current formation

Guiding-center simulations of stormtime transport of ring-current and radiation-belt ions having first adiabatic invariants mu is approximately greater than 15 MeV/G (E is approximately greater than 165 keV at L is approximately 3) are surprisingly well described (typically within a factor of approximately less than 4) by the quasilinear theory of radial diffusion. This holds even for the case of an individual model storm characterized by substorm-associated impulses in the convection electric field, provided that the actual spectrum of the electric field is incorporated in the quasilinear theory. Correction of the quasilinear diffusion coefficient D(sub LL)(sup ql) for drift-resonance broadening (so as to define D(sub LL)(sup ql)) reduced the typical discrepancy with the diffusion coefficients D(sub LL)(sup sim) deduced from guiding-center simulations of representative-particle trajectories to a factor of approximately 3. The typical discrepancy was reduced to a factor of approximately 1.4 by averaging D(sub LL)(sup sim), D(sub LL)(sup ql), and D(sub LL)(sup rb) over an ensemble of model storms characterized by different (but statistically equivalent) sets of substorm-onset times

An Introduction to “Microbial Biogeochemistry: A Special Issue of \u3ci\u3eAquatic Geochemistry\u3c/i\u3e Honoring Mark Hines”

(First paragraph) This issue of Aquatic Geochemistry is dedicated to the memory of Dr. Mark E. Hines (Fig. 1) and his contributions to the fields of microbial biogeochemistry and aquatic geochemistry. Mark passed away in March of 2018, and through his career as a researcher, teacher, mentor, colleague, and university administrator, he greatly influenced the lives of all around him. We hope that this volume will serve not only as a memory of Mark, but also as a way to recognize his significant influences and major contributions in the fields of carbon, sulfur, and trace element biogeochemistry

Context and complexity: a longitudinal study of motivational dynamics among South Korean university students

This thesis reports on a longitudinal qualitative study of the L2 motivational systems of a group of South Korean university students. The study adopts a complex dynamics system approach to the collection and analysis of data, and develops an original three-level model of context to investigate the interaction of elements within the learners’ motivational systems and to track how these interactions led to perceptible changes in these systems over the course of the research. The study highlights the complex, dynamic nature of L2 motivation and the necessity of including context as a key part of the L2 motivational system. It further calls into question traditional conceptions of autonomy in the field and the general applicability of some current concepts in L2 motivation. In addition, it emphasizes the importance of non-quantitative approaches in illuminating the motivational processes at work within individuals. On the basis of these findings, the thesis calls for the general incorporation of complexity perspectives in L2 motivation research and for language pedagogy to incorporate the insights gained from such studies to enhance the classroom environments and learners’ investment in language learning

Hydraulic Resistance of Grass Media on Shallow Overland Flow

Simulated dense vegetation with random blade arrangements and different blade flexibilities were used to determine the hydraulic properties of flow of small, non-submerging depths. With the water flowing among the randomly patterned vegetation blades, drag resistance becomes the dominant force that retards the flow. An equation of flow was established based on the momentum balance in the system. Experimental results were used to determine the coefficient of blade resistance, RD, and plotted in terms of blade width and flow depth Reynolds number respectively

Disability Severity, Professional Isolation Perceptions, and Career Outcomes: When Does Leader–Member Exchange Quality Matter?

Employees with disability-related communication impairment often experience isolation from professional connections that can negatively affect their careers. Management research suggests that having lower quality leader relationships can be an obstacle to the development of professional connections for employees with disabilities. However, in this paper we suggest that lower quality leader–member exchange (LMX) relationships may not be a uniform hurdle for the professional isolation of employees with disability-related communication impairment. Drawing on psychological disengagement theory, we predict that employees with more severe, rather than less severe, communication impairment develop resilience to challenges in lower quality LMX relationships by psychologically disengaging from professional connections and, in turn, bear fewer negative consequences of professional isolation on career outcomes. In two studies of deaf and hard of hearing employees, we find that in lower quality LMX relationships employees with more severe communication impairment perceive being less isolated than employees with less severe communication impairment, and, in turn, report better career outcomes. Overall, our findings suggest that employees with more severe communication impairment may develop effective coping strategies to manage challenges of perceived professional isolation for career outcomes when in lower quality LMX relationships

Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice

Acknowledgments We thank Luca Giordano, Giovanni Esposito and Angelo Russo for technical assistance and Dr. Livio Luongo (Second University of Naples–Italy) for critical discussions. This work was supported by a Grant PRIN from Ministry of Education, Universities and Research (MIUR), Italy, to A.C. and the Wellcome Trust (WT098012) to L.K.H. and BBSRC (BB/K001418/1) to L.K.H. and G.D’A. G.D’A. received partial supports from a “FORGIARE” post-doctoral fellowship cofounded by the Polo delle Scienze e Tecnologie per la Vita, University of Naples Federico II and Compagnia di San Paolo Foundation, Turin, Italy (2010–2012).Peer reviewedPublisher PD