Fluid-Induced Propulsion of Rigid Particles in Wormlike Micellar Solutions

In the absence of inertia, a reciprocal swimmer achieves no net motion in a viscous Newtonian fluid. Here, we investigate the ability of a reciprocally actuated particle to translate through a complex fluid that possesses a network using tracking methods and birefringence imaging. A geometrically polar particle, a rod with a bead on one end, is reciprocally rotated using magnetic fields. The particle is immersed in a wormlike micellar (WLM) solution that is known to be susceptible to the formation of shear bands and other localized structures due to shear-induced remodeling of its microstructure. Results show that the nonlinearities present in this WLM solution break time-reversal symmetry under certain conditions, and enable propulsion of an artificial "swimmer." We find three regimes dependent on the Deborah number (De): net motion towards the bead-end of the particle at low De, net motion towards the rod-end of the particle at intermediate De, and no appreciable propulsion at high De. At low De, where the particle time-scale is longer then the fluid relaxation time, we believe that propulsion is caused by an imbalance in the fluid first normal stress differences between the two ends of the particle (bead and rod). At De~1, however, we observe the emergence of a region of network anisotropy near the rod using birefringence imaging. This anisotropy suggests alignment of the micellar network, which is "locked in" due to the shorter time-scale of the particle relative to the fluid

A 100-element HBT grid amplifier

A 100-element 10-GHz grid amplifier has been developed. The active devices in the grid are chips with heterojunction-bipolar-transistor (HBT) differential pairs. The metal grid pattern was empirically designed to provide effective coupling between the HBTs and free space. Two independent measurements, one with focusing lenses and the other without, were used to characterize the grid. In each case, the peak gain was 10 dB at 10 GHz with a 3-dB bandwidth of 1 GHz. The input and output return losses were better than 15 dB at 10 GHz. The maximum output power was 450 mW, and the minimum noise figure was 7 dB. By varying the bias, a signal could be amplitude modulated with a modulation index as large as 0.65. Tests show that the grid was quite tolerant of failures-the output power dropped by only 1 dB when 10% of the inputs were detuned. The grid amplifier is a multimode device that amplifies beams of different shapes and angles. Beams with incidence angles up to 30° were amplified with less than a 3-dB drop in gain

A serious game for the learning of vibrotactile feedbacks presented under the foot : how many and how fast?

Vision and auditory channels are often used to convey information quickly. Knowing that hearing and vision are generally loaded with plenty of stimuli, the use of touch as an alternative medium of communication could unload those senses. Although many studies have been conducted on hapic icons or tactile icons, few of them have focused on the foot as a medium of communication. This paper particularly investigate the maximum number of vibrotactile messages that could be memorized when displayed under the foot. The method is based on a daily training wrapped in a serious game. In the latter, the avatar must be led to different locations through risky path. Risky events are displayed along the route through vibrotactile feedbacks, which have to be identified by the player. A preliminary experiment shows the usability of this serious game for learning a large number of vibrotactile stimuli

Valproate Protein Binding Is Highly Variable in ICU Patients and Not Predicted by Total Serum Concentrations: A Case Series and Literature Review

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/1/phar1912-sup-0001-SupInfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/2/phar1912_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/3/phar1912.pd

Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic.

Recent outbreaks of H5, H7, and H9 influenza A viruses in humans have served as a vivid reminder of the potentially devastating effects that a novel pandemic could exert on the modern world. Those who have survived infections with influenza viruses in the past have been protected from subsequent antigenically similar pandemics through adaptive immunity. For example, during the 2009 H1N1 "swine flu" pandemic, those exposed to H1N1 viruses that circulated between 1918 and the 1940s were at a decreased risk for mortality as a result of their previous immunity. It is also generally thought that past exposures to antigenically dissimilar strains of influenza virus may also be beneficial due to cross-reactive cellular immunity. However, cohorts born during prior heterosubtypic pandemics have previously experienced elevated risk of death relative to surrounding cohorts of the same population. Indeed, individuals born during the 1890 H3Nx pandemic experienced the highest levels of excess mortality during the 1918 "Spanish flu." Applying Serfling models to monthly mortality and influenza circulation data between October 1997 and July 2014 in the United States and Mexico, we show corresponding peaks in excess mortality during the 2009 H1N1 "swine flu" pandemic and during the resurgent 2013-2014 H1N1 outbreak for those born at the time of the 1957 H2N2 "Asian flu" pandemic. We suggest that the phenomenon observed in 1918 is not unique and points to exposure to pandemic influenza early in life as a risk factor for mortality during subsequent heterosubtypic pandemics.IMPORTANCE The relatively low mortality experienced by older individuals during the 2009 H1N1 influenza virus pandemic has been well documented. However, reported situations in which previous influenza virus exposures have enhanced susceptibility are rare and poorly understood. One such instance occurred in 1918-when those born during the heterosubtypic 1890 H3Nx influenza virus pandemic experienced the highest levels of excess mortality. Here, we demonstrate that this phenomenon was not unique to the 1918 H1N1 pandemic but that it also occurred during the contemporary 2009 H1N1 pandemic and 2013-2014 H1N1-dominated season for those born during the heterosubtypic 1957 H2N2 "Asian flu" pandemic. These data highlight the heretofore underappreciated phenomenon that, in certain instances, prior exposure to pandemic influenza virus strains can enhance susceptibility during subsequent pandemics. These results have important implications for pandemic risk assessment and should inform laboratory studies aimed at uncovering the mechanism responsible for this effect

Phase diagram of insulating crystal and quantum Hall states in ABC-stacked trilayer graphene

In the presence of a perpendicular magnetic field, ABC-stacked trilayer graphene's chiral band structure supports a 12-fold degenerate N=0 Landau level (LL). Along with the valley and spin degrees of freedom, the zeroth LL contains additional quantum numbers associated with the LL orbital index $$. Remote inter-layer hopping terms and external potential difference $\Delta_{B}$ between the layers lead to LL splitting by introducing a gap $$ between the degenerate zero-energy triplet LL orbitals. Assuming that the spin and valley degrees of freedom are frozen, we study the phase diagram of this system resulting from competition of the single particle LL splitting and Coulomb interactions within the Hartree-Fock approximation at integer filling factors. Above a critical value $\Delta_{LL}^{c}$ of the external potential difference i,e, for $|\Delta_{LL}| >\Delta_{LL}^{c}$, the ground state is a uniform quantum Hall state where the electrons occupy the lowest unoccupied LL orbital index. For $|\Delta_{LL}| <\Delta_{LL}^{c}$ (which corresponds to large positive or negative values of $\Delta_{B}$) the uniform QH state is unstable to the formation of a crystal state at integer filling factors. This phase transition should be characterized by a Hall plateau transition as a function of $\Delta_{LL}$ at a fixed filling factor. We also study the properties of this crystal state and discuss its experimental detection.Comment: 16 pages with 13 figure

KELT-20b: A Giant Planet with a Period of P ~ 3.5 days Transiting the V ~ 7.6 Early A Star HD 185603

We report the discovery of KELT-20b, a hot Jupiter transiting a V ~ 7.6 early A star, HD 185603, with an orbital period of P ≃ 3.47 days. Archival and follow-up photometry, Gaia parallax, radial velocities, Doppler tomography, and AO imaging were used to confirm the planetary nature of KELT-20b and characterize the system. From global modeling we infer that KELT-20 is a rapidly rotating (ν sin I* ≃ 120 km s^(-1)) A2V star with an effective temperature of T_(eff) = 8730^(+250)_(-260) K, mass of, M* = ^(+0.14)_(-0.20) M⊙ radius of, R* = 1.561^(+0.058)_(-0.064) R⊙ surface gravity of, log g* = 4.292^(+0.017)_(-0.020), and age of ≾600 Myr. The planetary companion has a radius of R_P = 1.735^(+0.070)_(-0.075) R_J, a semimajor axis of a = 0.0542^(+0.0014)_(-0.0021) au, and a linear ephemeris of BJD_(TDB) = 2457503.120049 ± 0.000190 + E(3.4741070 ± 0.0000019). We place a 3σ upper limit of ~3.5 M_J on the mass of the planet. Doppler tomographic measurements indicate that the planetary orbit normal is well aligned with the projected spin axis of the star (λ = 3.°4± 2.°1). The inclination of the star is constrained to 24.°4 < I* < 155.°6, implying a three-dimensional spin–orbit alignment of 1.°3 < ψ < 69.°8. KELT-20b receives an insolation flux of ~8 x 10^9 erg s^(-1) cm^(-2), implying an equilibrium temperature of of ~2250 K, assuming zero albedo and complete heat redistribution. Due to the high stellar T_(eff), KELT-20b also receives an ultraviolet (wavelength d ⩽ 91.2 nm) insolation flux of ~9.1 x 10^4 erg s^(-1) cm^(-2), possibly indicating significant atmospheric ablation. Together with WASP-33, Kepler-13 A, HAT-P-57, KELT-17, and KELT-9, KELT-20 is the sixth A star host of a transiting giant planet, and the third-brightest host (in V) of a transiting planet

Evaluation of exposure-specific risks from two independent samples: A simulation study

<p>Abstract</p> <p>Background</p> <p>Previous studies have proposed a simple product-based estimator for calculating exposure-specific risks (ESR), but the methodology has not been rigorously evaluated. The goal of our study was to evaluate the existing methodology for calculating the ESR, propose an improved point estimator, and propose variance estimates that will allow the calculation of confidence intervals (CIs).</p> <p>Methods</p> <p>We conducted a simulation study to test the performance of two estimators and their associated confidence intervals: 1) current (simple product-based estimator) and 2) proposed revision (revised product-based estimator). The first method for ESR estimation was based on multiplying a relative risk (RR) of disease given a certain exposure by an overall risk of disease. The second method, which is proposed in this paper, was based on estimates of the risk of disease in the unexposed. We then multiply the updated risk by the RR to get the revised product-based estimator. A log-based variance was calculated for both estimators. Also, a binomial-based variance was calculated for the revised product-based estimator. 95% CIs were calculated based on these variance estimates. Accuracy of point estimators was evaluated by comparing observed relative bias (percent deviation from the true estimate). Interval estimators were evaluated by coverage probabilities and expected length of the 95% CI, given coverage. We evaluated these estimators across a wide range of exposure probabilities, disease probabilities, relative risks, and sample sizes.</p> <p>Results</p> <p>We observed more bias and lower coverage probability when using the existing methodology. The revised product-based point estimator exhibited little observed relative bias (max: 4.0%) compared to the simple product-based estimator (max: 93.9%). Because the simple product-based estimator was biased, 95% CIs around this estimate exhibited small coverage probabilities. The 95% CI around the revised product-based estimator from the log-based variance provided better coverage in most situations.</p> <p>Conclusion</p> <p>The currently accepted simple product-based method was only a reasonable approach when the exposure probability is small (< 0.05) and the RR is ≤ 3.0. The revised product-based estimator provides much improved accuracy.</p