Spurious phase in a model for traffic on a bridge

We present high-precision Monte Carlo data for the phase diagram of a two-species driven diffusive system, reminiscent of traffic across a narrow bridge. Earlier studies reported two phases with broken symmetry; the existence of one of these has been the subject of some debate. We show that the disputed phase disappears for sufficiently large systems and/or sufficiently low bulk mobility.Comment: 8 pages, 3 figures, JPA styl

When two worlds collide: A story about collaboration, witnessing and life story research with soldiers returning from war

The story we share here stems from our research with British military personnel who are adapting to life with a physical and/or psychological disability after serving in the Iraq or Afghanistan wars. Throughout our research, we have struggled to answer the kinds of questions that plague qualitative researchers: How might we gain insights into intense, traumatic, even life-changing experiences? Should we be inviting individuals to recount or revisit such potent moments from their lives? What interpretive framework might we draw on to make sense of what are sometimes senseless experiences? How can we share any ensuing understanding with others without diluting, diminishing or disrespecting the lives of soldiers or their families? The story we share here – which responds to Denzin’s (2003) challenge to reanimate life and Erickson’s (2010) provocation to do so with greater modesty, visibility, and reflexivity – offers one answer to these questions

Setting the Stage for Co-Production

Participatory scenario visioning aims to expose, integrate, and reconcile perspectives and expectations about a sustainable, resilient future from a variety of actors and stakeholders. This chapter considers the settings in which transdisciplinary participatory visioning takes place, highlighting lessons learned from the Urban Resilience to Extremes Sustainability Research Network (UREx SRN). It reflects on the benefits of engaging in the co-production process and the challenges that must be considered amid this process

Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on Bone

Bisphosphonates (BPs) slow bone loss by reducing initiation of new basic multicellular units (BMUs). Whether or not BPs simply prevent osteoclasts from initiating new BMUs that resorb bone or also reduce the amount of bone they resorb at the BMU level is not clear. The goal of this study was to determine the effects of BPs on three morphological parameters of individual BMUs, resorption depth (Rs.De), area (Rs.Ar), and width (Rs.Wi). After 1 year of treatment with vehicle (VEH), alendronate (ALN; 0.10, 0.20, or 1.00 mg/kg/day), or risedronate (RIS; 0.05, 0.10, or 0.50 mg/kg/day), resorption cavity morphology was assessed in vertebral trabecular bone of beagle dogs by histology. Animals treated with ALN or RIS at the doses representing those used to treat postmenopausal osteoporosis (0.20 and 0.10 mg/kg/day, respectively) had significantly lower Rs.Ar (−27%) and Rs.Wi (−17%), with no difference in Rs.De, compared to VEH-treated controls. Low doses of ALN and RIS did not affect any parameters, whereas higher doses resulted in similar changes to those of the clinical dose. There were no significant differences in the resorption cavity measures between RIS and ALN at any of the dose equivalents. These results highlight the importance of examining parameters beyond erosion depth for assessment of resorption parameters. Furthermore, these results suggest that in addition to the well-known effects of BPs on reducing the number of active BMUs, these drugs also reduce the activity of osteoclasts at the individual BMU level at doses at and above those used clinically for the treatment of postmenopausal osteoporosis

A Framework for Resilient Urban Futures

Resilient urban futures provides a social–ecological–technological systems (SETS) perspective on promoting and understanding resilience. This chapter introduces the concepts, research, and practice of urban resilience from the Urban Resilience to Extremes Sustainability Research Network (UREx SRN). It describes conceptual and methodological approaches to address how cities experience extreme weather events, adapt to climate resilience challenges, and can transform toward sustainable and equitable future

Positive Futures

We describe the rationale and framework for developing scenarios of positive urban futures. The scenario framework is conducted in participatory workshop settings and composed of three distinct scenario approaches that are used to (1) explore potential outcomes of existing planning goals (strategic scenarios), (2) articulate visions that address pressing resilience challenges (adaptive scenarios), and (3) envision radical departures from the status quo in the pursuit of sustainability and equity (transformative scenarios). A series of creative and analytical processes are used to engage the community in imagining, articulating, and scrutinizing visions and pathways of positive futures. The approach offers an alternative and complement to traditional forecasting techniques by applying inspirational stories to resilience research and practice

Study protocol: NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC trial): a randomised controlled trial

Introduction Congenital heart disease (CHD) is a major cause of infant mortality. Many infants with CHD require corrective surgery with most operations requiring cardiopulmonary bypass (CPB). CPB triggers a systemic inflammatory response which is associated with low cardiac output syndrome (LCOS), postoperative morbidity and mortality. Delivery of nitric oxide (NO) into CPB circuits can provide myocardial protection and reduce bypass-induced inflammation, leading to less LCOS and improved recovery. We hypothesised that using NO during CPB increases ventilator-free days (VFD) (the number of days patients spend alive and free from invasive mechanical ventilation up until day 28) compared with standard care. Here, we describe the NITRIC trial protocol. Methods and analysis The NITRIC trial is a randomised, double-blind, controlled, parallel-group, two-sided superiority trial to be conducted in six paediatric cardiac surgical centres. One thousand three-hundred and twenty infants <2 years of age undergoing cardiac surgery with CPB will be randomly assigned to NO at 20 ppm administered into the CPB oxygenator for the duration of CPB or standard care (no NO) in a 1:1 ratio with stratification by age (<6 and ≥6 weeks), single ventricle physiology (Y/N) and study centre. The primary outcome will be VFD to day 28. Secondary outcomes include a composite of LCOS, need for extracorporeal membrane oxygenation or death within 28 days of surgery; length of stay in intensive care and in hospital; and, healthcare costs. Analyses will be conducted on an intention-to-treat basis. Preplanned secondary analyses will investigate the impact of NO on host inflammatory profiles postsurgery. Ethics and dissemination The study has ethical approval (HREC/17/QRCH/43, dated 26 April 2017), is registered in the Australian New Zealand Clinical Trials Registry (ACTRN12617000821392) and commenced recruitment in July 2017. The primary manuscript will be submitted for publication in a peer-reviewed journal. Trial registration number ACTRN12617000821392.</p

Assessing Future Resilience, Equity, and Sustainability in Scenario Planning

In the absence of strong international agreements, many municipal governments are leading efforts to build resilience to climate change in general and to extreme weather events in particular. However, it is notoriously difficult to guide and activate processes of change in complex adaptive systems such as cities. Participatory scenario planning with city professionals and members of civil society provides an opportunity to coproduce positive visions of the future. Yet, not all visions are created equal. In this chapter, we introduce the Resilience, Equity, and Sustainability Qualitative (RESQ) assessment tool that we have applied to compare positive scenario visions for cities in the USA and Latin America. We use the tool to examine the visions of the two desert cities in the Urban Resilience to Extreme Events Sustainability Research Network (UREx SRN), which are Hermosillo (Mexico) and Phoenix (United States)

The UREx Guide to Scenarios

This Scenario Planning Guide outlines how the Urban Resilience to Extremes Sustainability Research Network (UREx SRN) supports ongoing efforts in its nine network cities in conducting participatory workshops. The Scenarios Working Group team, together with students, researchers, and collaborators across the network, have synthesized the co-produced visions from Workshop I. City-leads, practitioners, network participants, and participating institutions are encouraged to use the quantitative and qualitative outputs to further develop resilient, equitable, and sustainable transition pathways to help bring about their envisioned futures. The primer begins with a brief description of the UREx SRN, before introducing the innovative framework applied to participatory scenario workshops. This is followed by an outline of the social-ecological-technological systems (SETS) approach that is applied throughout the project. A general explanation of scenarios is given, and a detailed description is provided of why scenario planning is applied, and the types of scenarios produced. The main portion of the primer focuses on the scenario workshops with detailed information provided on pre-workshop events, workshop activities and post-workshop data analysis and product synthesis