136 research outputs found
No Role for Triple Antiplatelet Therapy?⁎⁎Editorials published in the Journal of the American College of Cardiology reflect the views of the authors and do not necessarily represent the views of JACC or the American College of Cardiology.
TCT-51 Comparison of Clopidogrel and Prasugrel in Patients with Unprotected Left main Disease Treated with Everolimus-Eluting Stents: Insight From the Florence Left Main-PCI Registry
Estimate of myocardial salvage in late presentation acute myocardial infarction by comparing functional and perfusion abnormalities in predischarge gated SPECT.
The Impact of Right Coronary Artery Chronic Total Occlusion on Clinical Outcome of Patients Undergoing Percutaneous Coronary Intervention for Unprotected Left Main Disease
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Prognostic implications of restrictive left ventricular filling in reperfused anterior acute myocardial infarction
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Relationship of sustained brain natriuretic peptide release after reperfused acute myocardial infarction with gated SPECT infarct measurements and its connection with collagen turnover and left ventricular remodeling.
Spitzer spectral line mapping of protostellar outflows: II H2 emission in L1157
We present an analysis of Spitzer-IRS spectroscopic maps of the L1157
protostellar outflow in the H2 pure-rotational lines from S(0) to S(7). The aim
of this work is to derive the physical conditions pertaining to the warm
molecular gas and study their variations within the flow. The mid-IR H2
emission follows the morphology of the precessing flow, with peaks correlated
with individual CO clumps and H2 2.12{\mu}m ro-vibrational emission. More
diffuse emission delineating the CO cavities is detected only in the low-laying
transitions, with J(lower) less or equal to 2. The H2 line images have been
used to construct 2D maps of N(H2), H2 ortho-to-para ratio and temperature
spectral index beta, in the assumption of a gas temperature stratification
where the H2 column density varies as T^(beta). Variations of these parameters
are observed along the flow. In particular, the ortho-to-para ratio ranges from
0.6 to 2.8, highlighting the presence of regions subject to recent shocks where
the ortho-to-para ratio has not had time yet to reach the equilibrium value.
Near-IR spectroscopic data on ro-vibrational H2 emission have been combined
with the mid-IR data and used to derive additional shock parameters in the
brightest blue- and red-shifted emission knots. A high abundance of atomic
hydrogen (H/H2 about 0.1-0.3) is implied by the observed H2 column densities,
assuming n(H2) values as derived by independent SiO observations. The presence
of a high fraction of atomic hydrogen, indicates that a partially-dissociative
shock component should be considered for the H2 excitation in these localized
regions. However, planar shock models, either of C- or J-type, are not able to
consistently reproduce all the physical parameters derived from our analysis of
the H2 emission. Globally, H2 emission contributes to about 50% of the total
shock radiated energy in the L1157 outflow.Comment: 31 pages, 9 figure, Accepted for publication on Ap
Early changes of left ventricular filling pattern after reperfused ST-elevation myocardial infarction and doxycycline therapy: Insights from the TIPTOP trial
Bleeding events and maintenance dose of prasugrel: BLESS pilot study
OBJECTIVE: To evaluate changes in residual platelet reactivity (RPR) over time, and bleeding and ischaemic events rate using 5 vs 10 mg maintenance dose (MD) regimens of prasugrel 1 month after acute coronary syndrome (ACS). BACKGROUND: The optimal level of RPR with prasugrel may change over time after an ACS. METHODS: After 60 mg loading dose of prasugrel (T0) followed by 10 mg/day for 1 month, patients were randomised to receive prasugrel 10 mg/day (n=95, group A) or 5 mg/day MD (n=98, group B) up to 1 year. RPR was assessed at T0, 37 (T1) and 180 days (T2). The primary end point was Bleeding Academic Research Consortium (BARC) bleeding events ≥2 between 1 and 12 months, and the secondary composite end point was cardiac death, myocardial infarction, stroke and definite/probable stent thrombosis. RESULTS: From T0 to T1, RPR significantly increased in both groups A and B and the increase was higher for group B (δ ADP 10 µmol: 13.8%±14.7% vs 23.5%±19.2%, p=0.001). At T2 a lower rate of high RPR patients were found in group A (2.6% vs13.3%; p=0.014). The BARC type ≥2 bleeding occurred in 12.6% of group A versus 4.1% of group B (OR 0.29, 95% CI 0.09 to 0.94) and secondary end point in 2.1% vs 1.0% (p=0.542), respectively, without stent thrombosis. CONCLUSIONS: RPR increases shifting from 60 mg loading dose to 10 mg/day prasugrel MD with a further increase of RPR reducing prasugrel MD to 5 mg 1 month after ACS. Clinical value of these pharmacodynamic findings should be proved in larger clinical trials. TRIAL REGISTRATION NUMBER: NCT01790854
Residual thrombin potential predicts cardiovascular death in acute coronary syndrome patients undergoing percutaneous coronary intervention
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