THE ENVIRONMENTAL QUALITY INCENTIVES PROGRAM: LOCALLY MANAGING NATURAL RESOURCES

Environmental Economics and Policy, Resource /Energy Economics and Policy,

A CONTINUATION OF ENVIRONMENTAL CONSERVATION POLICY: THE CONSERVATION RESERVE PROGRAM

Environmental Economics and Policy, Land Economics/Use,

Analytic lymph node number establishes staging accuracy by occult tumor burden in colorectal cancer.

BACKGROUND AND OBJECTIVES: Recurrence in lymph node-negative (pN0) colorectal cancer suggests the presence of undetected occult metastases. Occult tumor burden in nodes estimated by GUCY2C RT-qPCR predicts risk of disease recurrence. This study explored the impact of the number of nodes analyzed by RT-qPCR (analytic) on the prognostic utility of occult tumor burden. METHODS: Lymph nodes (range: 2-159) from 282 prospectively enrolled pN0 colorectal cancer patients, followed for a median of 24 months (range: 2-63), were analyzed by GUCY2C RT-qPCR. Prognostic risk categorization defined using occult tumor burden was the primary outcome measure. Association of prognostic variables and risk category were defined by multivariable polytomous and semi-parametric polytomous logistic regression. RESULTS: Occult tumor burden stratified this pN0 cohort into categories of low (60%; recurrence rate (RR) = 2.3% [95% CI 0.1-4.5%]), intermediate (31%; RR = 33.3% [23.7-44.1%]), and high (9%; RR = 68.0% [46.5-85.1%], P \u3c 0.001) risk of recurrence. Beyond race and T stage, the number of analytic nodes was an independent marker of risk category (P \u3c 0.001). When \u3e12 nodes were analyzed, occult tumor burden almost completely resolved prognostic risk classification of pN0 patients. CONCLUSIONS: The prognostic utility of occult tumor burden assessed by GUCY2C RT-qPCR is dependent on the number of analytic lymph nodes

An uncorrelated state for the cortex?

The spike trains of nearby neurons in the sensory cortex are typically thought to be correlated due to mutual connections and common input. Multiple studies have measured these correlations and found them to be substantial (in the range of 10-40%). Two recent papers, however, reported that average correlations can be an order of magnitude smaller. Such low correlations could indicate an ‘uncorrelated state’ for the cortex, where cortical neurons act independently even in the face of strong common input

Cellular excitability and the regulation of functional neuronal identity: from gene expression to neuromodulation

The intrinsic properties of a neuron determine the translation of synaptic input to axonal output. It is this input– output relationship that is the heart of all nervous system activity. As such, the overall regulation of the intrinsic excitability of a neuron directly determines the output of that neuron at a given point in time, giving the cell a unique “functional identity.” To maintain this distinct functional output, neurons must adapt to changing patterns of synaptic excitation. These adaptations are essential to prevent neurons from either falling silent as synaptic excitation falls or becoming saturated as excitation increases. In the absence of stabilizing mechanisms, activity-dependent plasticity could drive neural activity to saturation or quiescence. Furthermore, as cells adapt to changing patterns of synaptic input, presumably the overall balance of intrinsic conductances of the cell must be maintained so that reliable output is achieved (Daoudal and Debanne, 2003; Turrigiano and Nelson, 2004; Frick and Johnston, 2005). Although these regulatory phenomena have been well documented, the molecular and physiological mechanisms involved are poorly understood

The Coronal X-ray Spectrum of the Multiple Weak-Lined T Tauri Star System HD 98800

We present high-resolution X-ray spectra of the multiple (hierarchical quadruple) weak-lined T Tauri star system HD 98800, obtained with the High Energy Transmission Gratings Spectrograph (HETGS) aboard the Chandra X-ray Observatory (CXO). In the zeroth-order CXO/HETGS X-ray image, both principle binary components of HD 98800 (A and B, separation 0.8'') are detected; component A was observed to flare during the observation. The infrared excess (dust disk) component, HD 98800B, is a factor ~4 fainter in X-rays than the apparently ``diskless'' HD 98800A, in quiescence. The line ratios of He-like species (e.g., Ne IX, O VII) in the HD 98800A spectrum indicate that the X-ray-emitting plasma around HD 98800 is in a typical coronal density regime (log n <~ 11). We conclude that the dominant X-ray-emitting component(s) of HD 98800 is (are) coronally active. The sharp spectral differences between HD 98800 and the classical T Tauri star TW Hya demonstrate the potential utility of high-resolution X-ray spectroscopy in providing diagnostics of pre-main sequence accretion processes.Comment: 11 pages, 5 figures; to appear in the Astrophysical Journal (Letters

DEMAND AND SUPPLY ASSESSMENT FOR THE MICHIGAN FROZEN POTATO INDUSTRY

This report presents a general assessment of the demand and supply conditions affecting the Michigan frozen potato industry. The information has been drawn from various secondary sources and interviews with key industry informants. The report is one of the major outputs of an ongoing study being prepared for the Michigan Potato Industry Commission and funded by the Michigan Agricultural Experiment Station. This analysis was necessitated by the 80% reduction in Michigan frozen processing potato acreage by Simplot in 1997. This reduction of 5,000 acres for the Grand Rapids processing facility has created both short-term and long-term concerns for the Michigan potato industry. This assessment provides broad background information relevant to determining why this cutback occurred and its likely impact if continued in the future. The report begins with a consideration of demand conditions, including both domestic and international demand trends for consumption and consumer preferences. The report then discusses supply issues, including current North American production capacity, international sourcing trends, competition from Canadian imports, cost considerations, processing innovation, and industry consolidation. The report concludes with a section addressing key strategic issues suggested by the demand and supply trends. NOTE: This staff paper contains text only. For charts and graphs (exhibits 1-17b) which have been omitted, contact Christopher Peterson at ([email protected]).Crop Production/Industries,

Tortious Interference: The Limits of Common Law Liability for Newsgathering

Media lawyers have recently been confronted with a relatively new source of litigation: the tort of intentional interference with contractual relations, which arises out of confidentiality agreements. In this Article, the authors identify the elements of tortious interference with contracts and examine the key issues presented when this tort is applied to newsgathering. The authors then consider a potential defense based on the First Amendment. In light of the public and constitutional interests at stake, the authors conclude that the breach of a confidentiality agreement should not sustain a tortious interference claim when the press is involved in newsgathering activity