Une infrastructure logicielle pour instrumenter l'expérimentation des EIAH

International audienceCet article a pour objet de présenter une plate-forme logicielle développée dans le but de faciliter le travail des chercheurs dans la mise en place et la réalisation d'expérimentations dans le domaine des EIAH. Ce travail a été réalisé dans le cadre de l'action « Shared Virtual Lab » (SVL) du réseau d'excellence Kaleidoscope, et les outils ont été exploités pour la réalisation d'une expérimentation complexe mettant en oeuvre simultanément plusieurs EIAH développés au sein de l'équipe MeTAH du LIG. Le scénario décrivant l'activité des élèves et des enseignants impliqués dans l'expérimentation est décrit en langage LDL et interprété par la plate-forme. Les traces d'activité produites par les logiciels expérimentés et par la plate-forme sont centralisées dans une base de données XML. Elles ont été exploitées en temps réel par un outil de suivi destiné aux enseignants

Análise dos processos pedagógicos com o novo modelo de gestão educacional: a gestão da qualidade na Escola Estadual Profª Roxana Pereira Bonessi

This is part of the dissertation in education presented the University of Jaén, Spain, in partnership with the University Foundation Iberoamericana/Brazil, which had as its object of study the analysis of pedagogical processes with the new model of educational management: quality management in state school Prof. Roxana Pereira Bonessi. The study investigated the influence of management changes and advances in the school model had the ten -year period in its process management and teaching and learning, observing the growth in Ideb and awards in the field of management. Given that this was the first state school of Amazonas teaching to deploy the Quality Management System - QMS - to receive the certification seal of ABNT NBT ISO 9001: 2008.Key-words: public school management, quality management, democracy management.Este texto faz parte da dissertação de mestrado em educação apresentada à Universidade de Jaén/Espanha, em convênio com a Fundação Universitária Ibero-americana/Brasil, que teve como objeto de estudo a análise dos processos pedagógicos com o novo modelo de gestão educacional: a gestão da qualidade na escola estadual Profª Roxana Pereira Bonessi. A pesquisa abordou a influência do modelo de gestão nas mudanças e avanços que a escola teve no período de dez anos em seus processos de gestão e de ensino e aprendizagem, observando o crescimento no Ideb e prêmios no campo da gestão, tendo em vista que esta foi a primeira escola da rede estadual de ensino do Amazonas a implantar o Sistema de Gestão da Qualidade - SGQ - e receber o selo de certificação da ABNT NBT ISO 9001:2008.Palavras-chave: gestão escolar pública, gestão da qualidade, gestão democrática

Internet Predictions

More than a dozen leading experts give their opinions on where the Internet is headed and where it will be in the next decade in terms of technology, policy, and applications. They cover topics ranging from the Internet of Things to climate change to the digital storage of the future. A summary of the articles is available in the Web extras section

How do early-life adverse childhood experiences mediate the relationship between childhood socioeconomic conditions and adolescent health outcomes in the UK?

Background Both adverse childhood experiences (ACEs) and adverse childhood socioeconomic conditions (SECs) in early life are associated with poor outcomes across the life course. However, the complex interrelationships between childhood SECs and ACEs are unclear, as are the consequences for health outcomes beyond childhood. We therefore assessed the extent to which early-life ACEs mediate the relationship between SECs and socioemotional behavioural problems, cognitive disability and overweight/obesity in adolescence. Methods We used longitudinal data from the UK Millennium Cohort Study (MSC). Outcomes assessed at age 14 were socioemotional behavioural problems, cognitive disability and overweight/obesity. SECs at birth were measured by maternal education. Potentially mediating ACEs measured up to 5 years were verbal and physical maltreatment, parental drug use, domestic violence, parental divorce, maternal mental illness and high frequency of parental alcohol use. We used counterfactual mediation analysis to assess the extent to which ACEs mediate the association between SECs at birth and behavioural, cognitive and physical outcomes at age 14, estimating total (TE), natural direct and indirect effects, and mediated proportions. Results Children with disadvantaged SECs were more likely to have socioemotional behavioural problems (relative risk (RR) 3.85, 95% CI 2.48 to 5.97), cognitive disability (RR 3.87, 95% CI 2.33 to 6.43) and overweight/obesity (RR 1.61, 95% CI 1.32 to 1.95), compared to those with more advantaged SECs. Overall, 18% of the TE of SECs on socioemotional behavioural problems was mediated through all ACEs investigated. For cognitive disability and overweight/obese, the proportions mediated were 13% and 19%, respectively. Conclusion ACEs measured up to age 5 years in the MCS explained about one-sixth of inequalities in adolescents behavioural, cognitive and physical outcomes

Changes in the transcriptional profile of transporters in the intestine along the anterior-posterior and crypt-villus axes

BACKGROUND: The purpose of this work was to characterize the expression of drug and nutrient carriers along the anterior-posterior and crypt-villus axes of the intestinal epithelium and to study the validity of utilizing whole gut tissue rather than purified epithelial cells to examine regional variations in gene expression. RESULTS: We have characterized the mRNA expression profiles of 76 % of all currently known transporters along the anterior-posterior axis of the gut. This is the first study to describe the expression profiles of the majority of all known transporters in the intestine. The expression profiles of transporters, as defined according to the Gene Ontology consortium, were measured in whole tissue of the murine duodenum, jejunum, ileum and colon using high-density microarrays. For nine transporters (Abca1, Abcc1, Abcc3, Abcg8, Slc10a2, Slc28a2, Slc2a1, Slc34a2 and Slc5a8), the mRNA profiles were further measured by RT-PCR in laser micro-dissected crypt and villus epithelial cells corresponding to the aforementioned intestinal regions. With respect to differentially regulated transporters, the colon had a distinct expression profile from small intestinal segments. The majority (59 % for p cutoff ≤ 0.05) of transporter mRNA levels were constant across the intestinal sections studied. For the transporter subclass "carrier activity", which contains the majority of known carriers for biologically active compounds, a significant change (p ≤ 0.05) along the anterior-posterior axis was observed. CONCLUSION: All nine transporters examined in laser-dissected material demonstrated good replication of the region-specific profiles revealed by microarray. Furthermore, we suggest that the distribution characteristics of Slc5a8 along the intestinal tract render it a suitable candidate carrier for monocarboxylate drugs in the posterior portion of the intestine. Our findings also predict that there is a significant difference in the absorption of carrier-mediated compounds in the different intestinal segments. The most pronounced differences can be expected between the adjoining segments ileum and colon, but the differences between the other adjoining segments are not negligible. Finally, for the examined genes, profiles measured in whole intestinal tissue extracts are representative of epithelial cell-only gene expression

Supporting Indigenous Adaptation in a Changing Climate: Insights from the Stó:lō Research and Resource Management Centre (British Columbia) and the Fort Apache Heritage Foundation (Arizona)

Indigenous peoples are both disproportionately threatened by global climate change and uniquely positioned to enhance local adaptive capacities. We identify actions that support Indigenous adaptation based on organizational and community perspectives. Our data come from two Indigenous organizations that share cultural heritage stewardship missions—the Stó:lō Research and Resource Management Centre (Stó:lō Nation, British Columbia) and the Fort Apache Heritage Foundation (White Mountain Apache Tribe, Arizona). These organizations collaborated with us in exploring community perceptions of climate effects, investigating community adaptation opportunities and constraints, and identifying actions that support Indigenous adaptation. Research methods included engagement with organizational collaborators and semi-structured interviews with organizational representatives and community members and staff. Results confirm that Stó:lō and Apache territories and communities have experienced climate change impacts, such as changes in temperature, hydrology, and increase in extreme weather events. Climate effects are cumulative to colonial depletion of traditional environments and further reduce access to traditional resources, practices, and food security. Results indicated that certain actions are identified by community members as adaptation enablers across case studies—most prominently, perpetuation of Indigenous culture and knowledge, climate education that is tailored to local contexts, collaborative decision-making among community institutions, and integration of climate adaptation into ongoing organizational programs. We conclude that Indigenous-owned organizations are engaged in the expansion of adaptive capacity and hold potential to further support their communities