Men?s preferences for treatment of early stage prostate cancer: Results from a discrete choice experiment, CHERE Working Paper 2006/14

Prostate cancer is the most common cancer in men in Australia; each year over 10,000 Australians are diagnosed with this disease. There are a number of treatment options for early stage prostate cancer (ESPC); radical prostatectomy, external beam radiotherapy, brachytherapy, hormonal therapy and combined therapy. Treatment can cause serious side-effects, including severe sexual and urinary dysfunction, bowel symptoms and fatigue. Furthermore, there is no evidence as yet to demonstrate that any of these treatments confers a survival gain over active surveillance (watchful waiting). While patient preferences should be important determinants in the type of treatment offered, little is known about patients? views of the relative tolerability of side effects and of the survival gains needed to justify these. To investigate this, a discrete choice experiment (DCE) was conducted in a sample of 357 men who had been treated for ESPC and 65 age-matched controls. The sample was stratified by treatment, with approximately equal numbers in each treatment group. The DCE included nine attributes: seven side-effects and two survival attributes (duration and uncertainty). An orthogonal fractional set of 108 scenarios from the full factorial was used to generate three versions of the questionnaire, with 18 scenarios per respondent. Multinomial logit (MNL) and mixed logit (MXL) models were estimated. A random intercept MXL model provided a significantly better fit to the data than the simple MNL model, and adding random coefficients for all attributes dramatically improved model fit. Each side-effect had a statistically significant mean effect on choice, as did survival duration. Most attributes had significant variance parameters, suggesting considerable heterogeneity among respondents in their preferences. To model this heterogeneity, we included men?s health-related quality of life scores following treatment as covariates to see whether their preferences were influenced by their previous treatment experience. This study demonstrate how DCEs can be used to quantify the trade-offs patients make between side-effects and survival gains. The results provide useful insights for clinicians who manage patients with ESPC, highlighting the importance of patient preferences in treatment decisions.Prostate cancer, discrete choice experiment, preferences, quality of life

Swimming with ShARCS: Comparison of On-sky Sensitivity With Model Predictions for ShaneAO on the Lick Observatory 3-meter Telescope

The Lick Observatory's Shane 3-meter telescope has been upgraded with a new infrared instrument (ShARCS - Shane Adaptive optics infraRed Camera and Spectrograph) and dual-deformable mirror adaptive optics (AO) system (ShaneAO). We present first-light measurements of imaging sensitivity in the Ks band. We compare measured results to predicted signal-to-noise ratio and magnitude limits from modeling the emissivity and throughput of ShaneAO and ShARCS. The model was validated by comparing its results to the Keck telescope adaptive optics system model and then by estimating the sky background and limiting magnitudes for IRCAL, the previous infra-red detector on the Shane telescope, and comparing to measured, published results. We predict that the ShaneAO system will measure lower sky backgrounds and achieve 20\% higher throughput across the $JHK$ bands despite having more optical surfaces than the current system. It will enable imaging of fainter objects (by 1-2 magnitudes) and will be faster to reach a fiducial signal-to-noise ratio by a factor of 10-13. We highlight the improvements in performance over the previous AO system and its camera, IRCAL.Comment: 13 pages, 5 figures, SPIE Astronomical Telescopes + Instrumentation, Montreal 201

Investigating invisible writing practices in the engineering curriculum using practice architectures

Writing practices are seen to be essential for professional engineers, yet many engineering students and academics struggle with written communication, despite years of interventions to improve student writing. Much has been written about the importance of getting engineering students to write, but there has been a little investigation of engineering academics’ perceptions of writing practices in the curriculum, and the extent to which these practices are visible to their students and to the academics. This paper draws on research from an ongoing study into the invisibility of writing practices in the engineering curriculum using a practice architectures lens. The paper uses examples from the sites of practice of two participants in the study to argue that prevailing practices in engineering education constrain more than enable the development and practice of writing in the engineering curriculu

Evaluation of Talking Parents, Healthy Teens, a new worksite based parenting programme to promote parent-adolescent communication about sexual health: randomised controlled trial

Objective To evaluate a worksite based parenting programme—Talking Parents, Healthy Teens—designed to help parents learn to address sexual health with their adolescent children

Comparative transfection of DNA into primary and transformed mammalian cells from different lineages

<p>Abstract</p> <p>Background</p> <p>The delivery of DNA into human cells has been the basis of advances in the understanding of gene function and the development of genetic therapies. Numerous chemical and physical approaches have been used to deliver the DNA, but their efficacy has been variable and is highly dependent on the cell type to be transfected.</p> <p>Results</p> <p>Studies were undertaken to evaluate and compare the transfection efficacy of several chemical reagents to that of the electroporation/nucleofection system using both adherent cells (primary and transformed airway epithelial cells and primary fibroblasts as well as embryonic stem cells) and cells in suspension (primary hematopoietic stem/progenitor cells and lymphoblasts). With the exception of HEK 293 cell transfection, nucleofection proved to be less toxic and more efficient at effectively delivering DNA into the cells as determined by cell proliferation and GFP expression, respectively. Lipofectamine and nucleofection of HEK 293 were essentially equivalent in terms of toxicity and efficiency. Transient transfection efficiency in all the cell systems ranged from 40%-90%, with minimal toxicity and no apparent species specificity. Differences in efficiency and toxicity were cell type/system specific.</p> <p>Conclusions</p> <p>In general, the Amaxa electroporation/nucleofection system appears superior to other chemical systems. However, there are cell-type and species specific differences that need to be evaluated empirically to optimize the conditions for transfection efficiency and cell survival.</p

Commissioning ShARCS: the Shane Adaptive optics infraRed Camera-Spectrograph for the Lick Observatory 3-m telescope

We describe the design and first-light early science performance of the Shane Adaptive optics infraRed Camera-Spectrograph (ShARCS) on Lick Observatory's 3-m Shane telescope. Designed to work with the new ShaneAO adaptive optics system, ShARCS is capable of high-efficiency, diffraction-limited imaging and low-dispersion grism spectroscopy in J, H, and K-bands. ShARCS uses a HAWAII-2RG infrared detector, giving high quantum efficiency (>80%) and Nyquist sampling the diffraction limit in all three wavelength bands. The ShARCS instrument is also equipped for linear polarimetry and is sensitive down to 650 nm to support future visible-light adaptive optics capability. We report on the early science data taken during commissioning.Comment: 9 pages, 7 figures. Presented at SPIE Astronomical Telescopes + Instrumentation conference, paper 9148-11

Attitudes Towards Guns: Associations with Alcohol Use and Impulsive Behaviors

This study was an investigation of the association of attitudes toward guns with self-reports of alcohol/drug use, and impulsivity. Participants included 160 male and female high school students, who completed five questions regarding attitudes toward guns, in addition to questions about alcohol/drug use. Data were analyzed using t-tests. Males were more likely to feel that a home was safer with a gun. Feeling positively about a gun was associated with alcohol use in males and impulsive, aggressive behavior in males and females. A greater understanding of attitudes toward guns must take into account gender, alcohol use, and impulsive and aggressive tendencies