Periodontal disease severity in subjects with dementia: A systematic review and meta-analysis

Background and objective: Despite clinical trials and reviews attempt to assess a possible relationship between dementia and periodontal disease, no meta-analysis has been performed and this issue remains undetermined. The aim of this study is to conduct a systematic review and meta-analysis to assess severity of periodontitis in subjects with dementia. Methods: The search was conducted in Pubmed, Embase/MEDLINE. Two independent reviewers extracted data and assessed the risk bias (Newcastle–Ottawa scale). Meta-analyses were performed using the means of probing depth (PD) and clinical attachment loss (CAL) in patients with or without dementia. The mean difference were analyzed (P ≤ 0.05). Results: Fourteen studies were included in the systematic review. In the qualitative analysis, most studies reported higher prevalence of periodontal disease in dementia patients. The studies had low risk of bias and two meta-analyses were performed for each parameter, including or not a cross-sectional study. The meta-analyses including the cross-sectional study demonstrated significant association between dementia and periodontal disease (mean difference: PD = 1.41; CAL = 1.40, P < 0.05), however, it wasn't confirmed when the cross-sectional study was removed (1.25 mm, P < 0.22) and CAL (1.20 mm, P < 0.22). Conclusion: Although the qualitative analysis have suggested worse periodontal conditions in dementia patients, due to different study types and the high heterogeneity among them, the meta-analysis does not support the association between dementia and severity of periodontal disease

Influence of systemic strontium ranelate on the progression and as adjunctive therapy for the nonsurgical treatment of experimental periodontitis

Strontium Ranelate (SR) presents overlapping osteoanabolic and anti-resorptive activity. However, the effects of SR on the progression of periodontitis through the alveolar bone and its potential applicability as adjunctive therapy to scaling and root pl

A 1000-yr-old tsunami in the Indian Ocean points to greater risk for East Africa

© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Maselli, V., Oppo, D., Moore, A. L., Gusman, A. R., Mtelela, C., Iacopini, D., Taviani, M., Mjema, E., Mulaya, E., Che, M., Tomioka, A. L., Mshiu, E., & Ortiz, J. D. A 1000-yr-old tsunami in the Indian Ocean points to greater risk for East Africa. Geology, 48(8), (2020): 808-813, doi:10.1130/G47257.1.The December 2004 Sumatra-Andaman tsunami prompted an unprecedented research effort to find ancient precursors and quantify the recurrence time of such a deadly natural disaster. This effort, however, has focused primarily along the northern and eastern Indian Ocean coastlines, in proximal areas hardest hit by the tsunami. No studies have been made to quantify the recurrence of tsunamis along the coastlines of the western Indian Ocean, leading to an underestimation of the tsunami risk in East Africa. Here, we document a 1000-yr-old sand layer hosting archaeological remains of an ancient coastal Swahili settlement in Tanzania. The sedimentary facies, grain-size distribution, and faunal assemblages indicate a tsunami wave as the most likely cause for the deposition of this sand layer. The tsunami in Tanzania is coeval with analogous deposits discovered at eastern Indian Ocean coastal sites. Numerical simulations of tsunami wave propagation indicate a megathrust earthquake generated by a large rupture of the Sumatra-Andaman subduction zone as the likely tsunami source. Our findings provide evidence that teletsunamis represent a serious threat to coastal societies along the western Indian Ocean, with implications for future tsunami hazard and risk assessments in East Africa.This work was funded by the National Geographic Society (grant N. CP-R008–17). Maselli acknowledges support from the Canada First Research Excellence Fund through the Ocean Frontier Institute. We are extremely grateful to the editor, two anonymous reviewers, J. Bourgeois, G. Eberli, A. Prendergast, and C. Gouramanis for all the suggestions provided, which greatly improved the quality of the manuscript. We would like to thank the United Republic of Tanzania and the University of Dar es Salaam for allowing us to perform the field work activity. This is ISMAR Bologna scientific contribution number 2024

A 1000-yr-old tsunami in the Indian Ocean points to greater risk for East Africa: reply

© The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Maselli, V., Oppo, D., Moore, A. L., Gusman, A. R., Mtelela, C., Iacopini, D., Taviani, M., Mjema, E., Mulaya, E., Che, M., Tomioka, A. L., Mshiu, E., & Ortiz, J. D. A 1000-yr-old tsunami in the Indian Ocean points to greater risk for East Africa: reply. Geology, 49(1), (2021): E516-E516, https://doi.org/10.1130/G48585Y.1.We appreciate Somerville’s (2020) interest in our work, and the opportunity to further expand the discussion about the occurrence of a trans-oceanic tsunami in the Indian Ocean generated by a megathrust earthquake ~1000 years ago. Somerville suggests a connection between the inferred tsunami deposit presented by us (Maselli et al., 2020) and a tsunami event reported to have occurred in Nagapattinam (India) in the year 900 CE and described in Kalaki Krishnamurty’s book (Rastogi and Jaiswal, 2006)

Platelet-rich fibrin for wound healing of palatal donor sites of free gingival grafts : systematic review and meta-analysis

Platelet-rich fibrin (PRF) has been referred to as a second-generation platelet concentrate, associated with improvements on the healing of palatal wounds followed by FGG harvesting. The aim of this systematic review and meta-analysis was to assess the c

Clinical Researach Histomarkers for Objectively Estimating Premorbid Vagal Tone Chronology in Gulf War Veterans' Illness and in Acute Stres Reaction

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Cyclic competition of four species: domains and interfaces

We study numerically domain growth and interface fluctuations in one- and two-dimensional lattice systems composed of four species that interact in a cyclic way. Particle mobility is implemented through exchanges of particles located on neighboring lattice sites. For the chain we find that domain growth strongly depends on the mobility, with a higher mobility yielding a larger domain growth exponent. In two space dimensions, when also exchanges between mutually neutral particles are possible, both domain growth and interface fluctuations display universal regimes that are independent of the predation and exchange rates.Comment: 14 pages, 7 figures, version accepted for publication in J. Stat. Mec

Moment Closure - A Brief Review

Moment closure methods appear in myriad scientific disciplines in the modelling of complex systems. The goal is to achieve a closed form of a large, usually even infinite, set of coupled differential (or difference) equations. Each equation describes the evolution of one "moment", a suitable coarse-grained quantity computable from the full state space. If the system is too large for analytical and/or numerical methods, then one aims to reduce it by finding a moment closure relation expressing "higher-order moments" in terms of "lower-order moments". In this brief review, we focus on highlighting how moment closure methods occur in different contexts. We also conjecture via a geometric explanation why it has been difficult to rigorously justify many moment closure approximations although they work very well in practice.Comment: short survey paper (max 20 pages) for a broad audience in mathematics, physics, chemistry and quantitative biolog

The Politics of Environmental Dispute Resolution

Also PCMA Working Paper #17.http://deepblue.lib.umich.edu/bitstream/2027.42/51148/1/380.pd