Charged Beads Enhance Cutaneous Wound Healing in Rhesus Non-Human Primates

Enhanced cutaneous wound healing by positively charged cross-linked diethylaminoethyl dextran beads (CLOD) was studied in a standardized incisional wound model in 20 adult and 20 geriatric 111acaca mulatta (rhesus) partitioned equally over five time periods. Physiologic saline served as a control. Soft-tissue linear incisions were prepared between and l cm inferior to the scapulae. There were four incisions per rhesus; each incision was 1.5 cm long with 1 cm of undisturbed tissue between incisions, and both the experimental CLDD and physiologic saline treatments were administered to each rhesus. The incision treatments were either CLDD and soft-tissue closure with 4-0 BioSyn sutures or sterile physiologic saline and closure with 4-0 BioSyn smures. The hypothesis was CLDD would enhance cutaneous wound repair. Verification of the h ypothesis consisted of clinical examinations and histologic and tensiometric evaluations on biopsy specimens at 10 and 15 days, whereas 5-day and 2- and 4-month groups were assessed clinically and biopsy specimens were assessed histolog ically. The clinical course of healing for all groups was unremarkable. At 10 days, incisions in adult rhesus treated with CLDD had a 30-percent greater tensile strength compared with the physiologic saline-treated incisions (p = 0.01), whereas for geriatric rhesus, the CLDD treatment proved to be 15 percent greater in tensile strength compared with the physiologic saline cohort (p = 0.11). By day 15, incisions in adult rhesus were 26 percent stronger than the saline treatment group (/J = 0.07), and the difference was 36 percent (p = 0.02) for the geriatric rhesus. From 5 through 15 days, histologic observations revealed a gradual decrease in quantity and integrity of CLOD, with no remnants ofCLDD at either 2 or 4 months. Macrophages and multinucleated giant cells wer.e localized in the dermis and were associated with the CLDD. These cells decreased commensurately with the decrease of CLDD beads. The data suggest that CLDD can enhance significantly the tensile properties of healing cutaneous wounds in both adult and geriatric rhesus. Moreover, if the wound healing is enhanced in geriatric patients, this finding may be clinically germane to conditions where wound healing is compromised, such as in diabetics and patients on steroids

Spatial Variability of Turbulent Fluxes in the Roughness Sublayer of an Even-Aged Pine Forest

The spatial variability of turbulent flow statistics in the roughness sublayer (RSL) of a uniform even-aged 14 m (= h) tall loblolly pine forest was investigated experimentally. Using seven existing walkup towers at this stand, high frequency velocity, temperature, water vapour and carbon dioxide concentrations were measured at 15.5 m above the ground surface from October 6 to 10 in 1997. These seven towers were separated by at least 100m from each other. The objective of this study was to examine whether single tower turbulence statistics measurements represent the flow properties of RSL turbulence above a uniform even-aged managed loblolly pine forest as a best-case scenario for natural forested ecosystems. From the intensive space-time series measurements, it was demonstrated that standard deviations of longitudinal and vertical velocities (σ u , σ w ) and temperature (σ T ) are more planar homogeneous than their vertical flux of momentum (u * 2 ) and sensible heat (H) counterparts. Also, the measured H is more horizontally homogeneous when compared to fluxes of other scalar entities such as CO 2 and water vapour. While the spatial variability in fluxes was significant (>15 %), this unique data set confirmed that single tower measurements represent the ‘canonical’ structure of single-point RSL turbulence statistics, especially flux-variance relationships. Implications to extending the ‘moving-equilibrium’ hypothesis for RSL flows are discussed. The spatial variability in all RSL flow variables was not constant in time and varied strongly with spatially averaged friction velocity u * , especially when u * was small. It is shown that flow properties derived from two-point temporal statistics such as correlation functions are more sensitive to local variability in leaf area density when compared to single point flow statistics. Specifically, that the local relationship between the reciprocal of the vertical velocity integral time scale (I w ) and the arrival frequency of organized structures (ū/h) predicted from a mixing-layer theory exhibited dependence on the local leaf area index. The broader implications of these findings to the measurement and modelling of RSL flows are also discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42512/1/10546_2004_Article_234383.pd

Representativeness of Eddy-Covariance flux footprints for areas surrounding AmeriFlux sites

Large datasets of greenhouse gas and energy surface-atmosphere fluxes measured with the eddy-covariance technique (e.g., FLUXNET2015, AmeriFlux BASE) are widely used to benchmark models and remote-sensing products. This study addresses one of the major challenges facing model-data integration: To what spatial extent do flux measurements taken at individual eddy-covariance sites reflect model- or satellite-based grid cells? We evaluate flux footprints—the temporally dynamic source areas that contribute to measured fluxes—and the representativeness of these footprints for target areas (e.g., within 250–3000 m radii around flux towers) that are often used in flux-data synthesis and modeling studies. We examine the land-cover composition and vegetation characteristics, represented here by the Enhanced Vegetation Index (EVI), in the flux footprints and target areas across 214 AmeriFlux sites, and evaluate potential biases as a consequence of the footprint-to-target-area mismatch. Monthly 80% footprint climatologies vary across sites and through time ranging four orders of magnitude from 103 to 107 m2 due to the measurement heights, underlying vegetation- and ground-surface characteristics, wind directions, and turbulent state of the atmosphere. Few eddy-covariance sites are located in a truly homogeneous landscape. Thus, the common model-data integration approaches that use a fixed-extent target area across sites introduce biases on the order of 4%–20% for EVI and 6%–20% for the dominant land cover percentage. These biases are site-specific functions of measurement heights, target area extents, and land-surface characteristics. We advocate that flux datasets need to be used with footprint awareness, especially in research and applications that benchmark against models and data products with explicit spatial information. We propose a simple representativeness index based on our evaluations that can be used as a guide to identify site-periods suitable for specific applications and to provide general guidance for data use

2016 Research & Innovation Day Program

A one day showcase of applied research, social innovation, scholarship projects and activities.https://first.fanshawec.ca/cri_cripublications/1003/thumbnail.jp

Combining search and action for mobile robots

Abstract — We explore the interconnection between search and action in the context of mobile robotics. The task of searching for an object and then performing some action with that object is important in many applications. Of particular interest to us is the idea of a robot assistant capable of performing worthwhile tasks around the home and office (e.g., fetching coffee, washing dirty dishes, etc.). We prove that some tasks allow for search and action to be completely decoupled and solved separately, while other tasks require the problems to be analyzed together. We complement our theoretical results with the design of a combined search/action approximation algorithm that draws on prior work in search. We show the effectiveness of our algorithm by comparing it to state-of-theart solvers, and we give empirical evidence showing that search and action can be decoupled for some useful tasks. Finally, we demonstrate our algorithm on an autonomous mobile robot performing object search and delivery in an office environment. I

Combining Search and Action for Mobile Robots

We explore the interconnection between search and action in the context of mobile robotics. The task of searching for an object and then performing some action with that object is important in many applications. Of particular interest to us is the idea of a robot assistant capable of performing worthwhile tasks around the home and office (e.g., fetching coffee, washing dirty dishes, etc.). We prove that some tasks allow for search and action to be completely decoupled and solved separately, while other tasks require the problems to be analyzed together. We complement our theoretical results with the design of a combined search/action approximation algorithm that draws on prior work in search. We show the effectiveness of our algorithm by comparing it to state-of-the-art solvers, and we give empirical evidence showing that search and action can be decoupled for some useful tasks. Finally, we demonstrate our algorithm on an autonomous mobile robot performing object search and delivery in an office environment.</p

The extraction of negative carbon ions from a volume cusp ion source

Acetylene and carbon dioxide gases are used in a filament-powered volume-cusp ion source to produce negative carbon ions for the purpose of carbon implantation for gettering applications. The beam was extracted to an energy of 25 keV and the composition was analyzed with a spectrometer system consisting of a 90° dipole magnet and a pair of slits. It is found that acetylene produces mostly C−2 ions (up to 92 µA), while carbon dioxide produces mostly O− with only trace amounts of C−. Maximum C−2 current was achieved with 400 W of arc power and, the beam current and composition were found to be highly dependent on the pressure in the source. The beam properties as a function of source settings are analyzed, and plasma properties are measured with a Langmuir probe. Finally, we describe testing of a new RF H− ion source, found to produce more than 6 mA of CW H− beam.peerReviewe

The extraction of negative carbon ions from a volume cusp ion source

Acetylene and carbon dioxide gases are used in a filament-powered volume-cusp ion source to produce negative carbon ions for the purpose of carbon implantation for gettering applications. The beam was extracted to an energy of 25 keV and the composition was analyzed with a spectrometer system consisting of a 90° dipole magnet and a pair of slits. It is found that acetylene produces mostly C−2 ions (up to 92 µA), while carbon dioxide produces mostly O− with only trace amounts of C−. Maximum C−2 current was achieved with 400 W of arc power and, the beam current and composition were found to be highly dependent on the pressure in the source. The beam properties as a function of source settings are analyzed, and plasma properties are measured with a Langmuir probe. Finally, we describe testing of a new RF H− ion source, found to produce more than 6 mA of CW H− beam.peerReviewe