INFLUENCE DE TRAITEMENTS A L'HORMONE SOMATOTROPE BOVINE SUR LA CROISSANCE PONDÉRALE D'AGNEAUX NORMAUX OU HYPOPHYSECTOMISÉS

International audienc

ÉVOLUTION DES TAUX PLASMATIQUES D'ACIDES GRAS LIBRES ET DES SUCRES RÉDUCTEURS LORS D'UN TRAITEMENT AUX HORMONES SOMATOTROPES PORCINE ET BOVINE CHEZ LE LAPIN HYPOPHYSECTOMISÉ

International audienc

ALLOMÉTRIE DE CROISSANCE CHEZ LE LAPIN (ORYCTOLAGUS CUNICULUS). I. — PRINCIPAUX ORGANES ET TISSUS

International audienc

Role of chemotherapy in 5000 patients with head and neck cancer treated by curative surgery: A subgroup analysis of the meta-analysis of chemotherapy in head and neck cancer.

To evaluate the effect of chemotherapy added to a surgical locoregional treatment (LRT) for patients with locally advanced head and neck squamous cell carcinoma (HNSCC). We studied the sub-group of trials with surgical LRT included in the meta-analysis on chemotherapy in head and neck cancer (MACH-NC). Data from published and unpublished randomized trials comparing the addition of chemotherapy to LRT in HNSCC patients were sought using electronic database searching for the period 1965-2000, hand searching and by contacting experts in the field. Trials with less than 60 patients, or preoperative radiotherapy or where the type of LRT could not be individually determined were excluded. All individual patient data were checked for internal consistency, compared with published reports, and validated with trialists. Data were pooled using a fixed-effect model. Heterogeneity was assessed using Cochrane test and I <sup>2</sup> statistic. Twenty-four trials were eligible (5000 patients). Chemotherapy improved overall survival (HR = 0.92 [95%CI: 0.85-0.99] p = 0.02). There was a significant interaction between treatment effect and timing of chemotherapy (p = 0.08 at pre-specified threshold of 0.10) with a greater effect for concomitant chemotherapy (HR = 0.79, 95%CI: 0.69-0.92). The benefit of chemotherapy was greater in women (HR <sub>women</sub>  = 0.63, 95%CI: 0.50-0.80) compared to men (HR <sub>men</sub>  = 0.96, 95%CI: 0.89-1.04; p for interaction = 0.001). This analysis confirmed the benefit of concomitant chemotherapy added to surgical LRT. The role of induction therapy as yet to be determined as it did not improve OS. Women may benefit more than men from chemotherapy

Las fronteras del istmo

Obra organizada en torno a seis ejes principales que estudian la importancia de comparar las fronteras y los tipos de gestión desde el punto de vista geopolítico, histórico y antropológico; las tramas de la organización del espacio actual; la influencia en la evolución de las sociedades debido a la violencia política y los conflictos armados; los movimientos migratorios internacionales; la integración política y económica y finalmente los lazos comunitarios y de las identidades relacionados con las vivencias fronterizas