3,077 research outputs found
Sensitivity to the KARMEN Timing Anomaly at MiniBooNE
We present sensitivities for the MiniBooNE experiment to a rare exotic pion
decay producing a massive particle, Q^0. This type of decay represents one
possible explanation for the timing anomaly reported by the KARMEN
collaboration. MiniBooNE will be able to explore an area of the KARMEN signal
that has not yet been investigated
The value of 'positive' clinical signs for weakness, sensory and gait disorders in conversion disorder: a systematic and narrative review.
Experts in the field of conversion disorder have suggested for the upcoming DSM-V edition to put less weight on the associated psychological factors and to emphasise the role of clinical findings. Indeed, a critical step in reaching a diagnosis of conversion disorder is careful bedside neurological examination, aimed at excluding organic signs and identifying 'positive' signs suggestive of a functional disorder. These positive signs are well known to all trained neurologists but their validity is still not established. The aim of this study is to provide current evidence regarding their sensitivity and specificity. We conducted a systematic search on motor, sensory and gait functional signs in Embase, Medline, PsycINfo from 1965 to June 2012. Studies in English, German or French reporting objective data on more than 10 participants in a controlled design were included in a systematic review. Other relevant signs are discussed in a narrative review. Eleven controlled studies (out of 147 eligible articles) describing 14 signs (7 motor, 5 sensory, 2 gait) reported low sensitivity of 8-100% but high specificity of 92-100%. Studies were evidence class III, only two had a blinded design and none reported on inter-rater reliability of the signs. Clinical signs for functional neurological symptoms are numerous but only 14 have been validated; overall they have low sensitivity but high specificity and their use should thus be recommended, especially with the introduction of the new DSM-V criteria
Tight Bounds for MIS in Multichannel Radio Networks
Daum et al. [PODC'13] presented an algorithm that computes a maximal
independent set (MIS) within
rounds in an -node multichannel radio network with communication
channels. The paper uses a multichannel variant of the standard graph-based
radio network model without collision detection and it assumes that the network
graph is a polynomially bounded independence graph (BIG), a natural
combinatorial generalization of well-known geographic families. The upper bound
of that paper is known to be optimal up to a polyloglog factor.
In this paper, we adapt algorithm and analysis to improve the result in two
ways. Mainly, we get rid of the polyloglog factor in the runtime and we thus
obtain an asymptotically optimal multichannel radio network MIS algorithm. In
addition, our new analysis allows to generalize the class of graphs from those
with polynomially bounded local independence to graphs where the local
independence is bounded by an arbitrary function of the neighborhood radius.Comment: 37 pages, to be published in DISC 201
Development of an experimental 10 T Nb3Sn dipole magnet for the CERN LHC
An experimental 1-m long twill aperture dipole magnet developed using a high-current Nb3Sn conductor in order to attain a magnetic field well beyond 10 T at 4.2 K is described. The emphasis in this Nb3Sn project is on the highest possible field within the known Large Hadron Collider (LHC) twin-aperture configuration. A design target of 11.5 T was chosen
CP Violation and Matter Effect in Long Baseline Neutrino Oscillation Experiments
We show simple methods how to separate pure CP violating effect from matter
effect in long baseline neutrino oscillation experiments with three generations
of neutrinos. We give compact formulae for neutrino oscillation probabilities
assuming one of the three neutrino masses (presumably tau-neutrino mass) to be
much larger than the other masses and the effective mass due to matter effect.
Two methods are shown: One is to observe envelopes of the curves of oscillation
probabilities as functions of neutrino energy; a merit of this method is that
only a single detector is enough to determine the presence of CP violation. The
other is to compare experiments with at least two different baseline lengths;
this has a merit that it needs only narrow energy range of oscillation data.Comment: 17 pages + 9 eps figures, LaTeX, errors are correcte
Quantum Einstein Gravity
We give a pedagogical introduction to the basic ideas and concepts of the
Asymptotic Safety program in Quantum Einstein Gravity. Using the continuum
approach based upon the effective average action, we summarize the state of the
art of the field with a particular focus on the evidence supporting the
existence of the non-trivial renormalization group fixed point at the heart of
the construction. As an application, the multifractal structure of the emerging
space-times is discussed in detail. In particular, we compare the continuum
prediction for their spectral dimension with Monte Carlo data from the Causal
Dynamical Triangulation approach.Comment: 87 pages, 13 figures, review article prepared for the New Journal of
Physics focus issue on Quantum Einstein Gravit
Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas
INTRODUCTION: The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S). METHODS: This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients. RESULTS: Claudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly (p < 0.001). High expression of Claudin 18.2 was neither associated with histomorphogical subtype, or tumor state, nor with overall survival. CONCLUSION: In Caucasian AEG/S patients, 17.1% appeared to be eligible for an anti-Claudin 18.2 therapy. Claudin 18.2 expression itself has no impact on prognosis and is not related to any tumor subtype
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