Electrochemical Monitoring Of Electrogalvanizing Solutions

The corrosion resistance of steel is vastly improved when a zinc cathodic protective layer is applied. In recent years there has been renewed interest in producing this galvanized coating electrolytically. As with many deposition processes, the control of the operating parameters is very important in order to produce good quality zinc coatings. The homogeneity, ductility and smoothness of the zinc layer are critical. These factors are usually influenced by the electrochemical nature of the solution and organic additives are often used to assist in control. Studies on the polarization behavior of solutions for electro galvanizing electrolytes were made. Cyclic voltammetry techniques were used to develop methods which might be applicable in monitoring the active organic content of liquor ice in solution. The morphologies and orientations of the zinc were studied using SEM and X-ray diffraction techniques. © 1986 Chapman and Hall Ltd

Displacement power spectrum measurement of a macroscopic optomechanical system at thermal equilibrium

The mirror relative motion of a suspended Fabry-Perot cavity is studied in the frequency range 3-10 Hz. The experimental measurements presented in this paper, have been performed at the Low Frequency Facility, a high finesse optical cavity 1 cm long suspended to a mechanical seismic isolation system identical to that one used in the VIRGO experiment. The measured relative displacement power spectrum is compatible with a system at thermal equilibrium within its environmental. In the frequency region above 3 Hz, where seismic noise contamination is negligible, the measurement distribution is stationary and Gaussian, as expected for a system at thermal equilibrium. Through a simple mechanical model it is shown that: applying the fluctuation dissipation theorem the measured power spectrum is reproduced below 90 Hz and noise induced by external sources are below the measurement.Comment: 11 pages, 9 figures, 2 tables, to be submitte

Safety and efficacy of the hybrid approach in coronary chronic total occlusion percutaneous coronary intervention: The Hybrid Video Registry

Objectives The aim of the Hybrid Video Registry (HVR) is to assess the acute safety and efficacy of the Hybrid Approach in comparison to other contemporary methods of CTO‐PCI. Background: Recently, multiple techniques in Percutaneous Coronary Intervention (PCI) for coronary Chronic Total Occlusions (CTO) have been synthesized into a method referred to as the “Hybrid Approach”. Methods About 194 video‐taped timed live cases from CTO‐PCI training workshops were analyzed by independent data abstractors and compared to three contemporary CTO‐PCI registries stratified by case complexity based on the J‐CTO score. Results Overall procedural success was 95% of all cases attempted with an excellent safety profile. In the most complex lesion subset, which made up 45% of all HVR cases, success was 92.8%, which was significantly higher than either the Royal Bromptom (78.9%), or Japanese‐CTO (73.3%) registries, P = 0.04 Hybrid vs. Royal Brompton, P = 0.006 Hybrid vs. Japanese‐CTO). The Hybrid Approach was also associated with shorter procedure times and lower contrast utilization. Conclusions In a real world angiographic registry of complex CTOs, the Hybrid Approach to CTO‐PCI is safe, and may be superior to other contemporary approaches to CTO intervention with respect to procedural success and efficiency among a diverse group of operators and lesion complexity

A novel splicing variant of col2a1 in a fetus with achondrogenesis type ii: Interpretation of pathogenicity of in-frame deletions

Achondrogenesis type II (ACG2) is a lethal skeletal dysplasia caused by dominant pathogenic variants in COL2A1. Most of the variants found in patients with ACG2 affect the glycine residue included in the Gly-X-Y tripeptide repeat that characterizes the type II collagen helix. In this study, we reported a case of a novel splicing variant of COL2A1 in a fetus with ACG2. An NGS analysis of fetal DNA revealed a heterozygous variant c.1267-2_1269del located in intron 20/exon 21. The variant occurred de novo since it was not detected in DNA from the blood samples of parents. We generated an appropriate minigene construct to study the effect of the variant detected. The minigene expression resulted in the synthesis of a COL2A1 messenger RNA lacking exon 21, which generated a predicted in-frame deleted protein. Usually, in-frame deletion variants of COL2A1 cause a phenotype such as Kniest dysplasia, which is milder than ACG2. Therefore, we propose that the size and position of an in-frame deletion in COL2A1 may be relevant in determining the phenotype of skeletal dysplasia

A novel ABCC6 variant causative of pseudoxanthoma elasticum

Pseudoxanthoma elasticum is an autosomal recessive heritable disorder caused by mutations in ABCC6. We describetwo siblings showing typical skin lesions and a clinical diagnosis of pseudoxanthoma elasticum. Genetic analysis ofABCC6 revealed a novel homozygous c.4041G > A variant located in the last position of exon 28 that compromises thesplicing donor site, resulting in a shorter messenger RNA. The deletion impairs the nucleotide-binding fold region,which is crucial for ABCC6 function

Identifying Exoplanets with Deep Learning. V. Improved Light Curve Classification for TESS Full Frame Image Observations

The TESS mission produces a large amount of time series data, only a small fraction of which contain detectable exoplanetary transit signals. Deep learning techniques such as neural networks have proved effective at differentiating promising astrophysical eclipsing candidates from other phenomena such as stellar variability and systematic instrumental effects in an efficient, unbiased and sustainable manner. This paper presents a high quality dataset containing light curves from the Primary Mission and 1st Extended Mission full frame images and periodic signals detected via Box Least Squares (Kov\'acs et al. 2002; Hartman 2012). The dataset was curated using a thorough manual review process then used to train a neural network called Astronet-Triage-v2. On our test set, for transiting/eclipsing events we achieve a 99.6% recall (true positives over all data with positive labels) at a precision of 75.7% (true positives over all predicted positives). Since 90% of our training data is from the Primary Mission, we also test our ability to generalize on held-out 1st Extended Mission data. Here, we find an area under the precision-recall curve of 0.965, a 4% improvement over Astronet-Triage (Yu et al. 2019). On the TESS Object of Interest (TOI) Catalog through April 2022, a shortlist of planets and planet candidates, Astronet-Triage-v2 is able to recover 3577 out of 4140 TOIs, while Astronet-Triage only recovers 3349 targets at an equal level of precision. In other words, upgrading to Astronet-Triage-v2 helps save at least 200 planet candidates from being lost. The new model is currently used for planet candidate triage in the Quick-Look Pipeline (Huang et al. 2020a,b; Kunimoto et al. 2021).Comment: accepted for publication in AJ. code can be found at: https://github.com/mdanatg/Astronet-Triage and data can be found at: https://zenodo.org/record/741157

Inertial control of the mirror suspensions of the VIRGO interferometer for gravitational wave detection

In order to achieve full detection sensitivity at low frequencies, the mirrors of interferometric gravitational wave detectors must be isolated from seismic noise. The VIRGO vibration isolator, called 'superattenuator', is fully effective at frequencies above 4 Hz. Nevertheless, the residual motion of the mirror at the mechanical resonant frequencies of the system are too large for the interferometer locking system and must be damped. A multidimensional feedback system, using inertial sensors and digital processing, has been designed for this purpose. An experimental procedure for determining the feedback control of the system has been defined. In this paper a full description of the system is given and experimental results are presented.Comment: 17 pages, 11 figures, accepted for publication on Review of Scientific Instrument

Monitoring multiple myeloma by idiotype-specific peptide binders of tumor-derived exosomes.

Abstract Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there is a lack of efficient technology platforms for exosome isolation and characterization. Multiple myeloma (MM) is an incurable B-cell malignancy due to the rapid development of drug-resistance. MM-released exosomes express the immunoglobulin B-cell receptor (Ig-BCR) of the tumor B-cells, which can be targeted by Idiotype-binding peptides (Id-peptides). In this study, we analyzed the production of MM-released exosomes in the murine 5T33MM multiple myeloma model as biomarkers of tumor growth. To this end, we selected Id-peptides by screening a phage display library using as bait the Ig-BCR expressed by 5T33MM cells. By FACS, the FITC-conjugated Id-peptides detected the MM-released exosomes in the serum of 5T33MM-engrafted mice, levels of which are correlated with tumor progression at an earlier time point compared to serum paraprotein. These results indicate that Id-peptide-based recognition of MM-released exosomes may represent a very sensitive diagnostic approach for clinical evaluation of disease progression