31 research outputs found
Management of pelvic fractures in dog
Pelvic fractures are common sequelae of major traumatic injury of dogs and cat which, comprise of at least 25% of all fractures in veterinary practice (Piermattei et al., 2006). Fracture of ilium, the most common fracture seen in the pelvis account for 46% of all pelvic fracture (Henry, 1985; De Camp, 2005). Whereas, acetabular fracture comprises 12 % of pelvic fractures in dogs (De Camp, 2005). In smaller dogs, most of the pelvic fractures recover without surgery. But immediate surgery is required within 72 hours if the fracture is unstable (Harasen, 2007). We hereby report the successful surgical management of unstable fracture of ilium and ischium of pelvis in a Spitz dog
Interpretation of Binary Pulsar Observations
The nature, dynamics and evolution of the three known radio pulsar binaries are discussed. The system containing 1913+16 appears to comprise two ~1.4 M⊙ components, and to undergo orbital decay as predicted by general relativity. It is proposed that 1913+16 has a neutron star companion and that 0655+64 and 0820+02 have white dwarf companions which should be observable optically
On the origin of neutron magnetic scattering in anti-site disordered Sr2FeMoO6 double perovskites
Anti-site disordering in Sr2FeMoO6 double perovskites (containing Mo atoms at
Fe positions, and viceversa) has recently been shown to have a dramatic
influence in their magnetic and magnetotransport properties. In the present
study, two polycrystalline Sr2FeMoO6 samples showing different degrees of
anti-site disorder (a nominally 'ordered' sample with 70% of cationic ordering
and a nominally 'disordered' sample with 18% of cationic ordering) have been
examined by magnetic measurements and neutron powder diffraction (NPD)
techniques in the 15-500K temperature range. Our main finding is that the
'disordered' sample exhibits a strong magnetic scattering (noticeable even at
500K), comparable to that displayed by the 'ordered' one below TC= 415 K. For
the 'disordered' sample, the magnetic scattering exhibited on low angle Bragg
positions, is not to be ascribed to a (non-existent) ferrimagnetic ordering:
our results suggest that it originates upon naturally-occurring groups of Fe
cations in which strong antiferromagnetic (AFM) Fe-O-Fe superexchange
interactions are promoted, similar to those existing in the LaFeO3 perovskite.
These Fe groups are not magnetically isolated, but coupled by virtue of Fe-O-Mo
AFM interactions, which maintain the long-range coherence of this AFM
structure. Susceptibility measurements confirm the presence of AFM interactions
below 770 K.Comment: 30 pages, 11 figures, to be published in PR
Extrinsic Magnetotransport Phenomena in Ferromagnetic Oxides
This review is focused on extrinsic magnetotransport effects in ferromagnetic
oxides. It consists of two parts; the second part is devoted to an overview of
experimental data and theoretical models for extrinsic magnetotransport
phenomena. Here a critical discussion of domain-wall scattering is given.
Results on surfacial and interfacial magnetism in oxides are presented.
Spin-polarized tunnelling in ferromagnetic junctions is reviewed and
grain-boundary magnetoresistance is interpreted within a model of
spin-polarized tunnelling through natural oxide barriers. The situation in
ferromagnetic oxides is compared with data and models for conventional
ferromagnets. The first part of the review summarizes basic material
properties, especially data on the spin-polarization and evidence for
half-metallicity. Furthermore, intrinsic conduction mechanisms are discussed.
An outlook on the further development of oxide spin-electronics concludes this
review.Comment: 133 pages, 47 figures, submitted to Rep. Prog. Phy
Pneumocystis jirovecii pneumonia in two patients with systemic lupus erythematosus after rituximab therapy
Interleukin-6 is essential for primary resistance to Francisella tularensis live vaccine strain infection.
We employed Francisella tularensis live vaccine strain (LVS) to study mechanisms of protective immunity against intracellular pathogens and, specifically, to understand protective correlates. One potential molecular correlate identified previously was interleukin-6 (IL-6), a cytokine with pleotropic roles in immunity, including influences on T and B cell functions. Given its role as an immune modulator and the correlation with successful anti-LVS vaccination, we examined the role IL-6 plays in the host response to LVS. IL-6-deficient (IL-6 knockout [KO]) mice infected with LVS intradermally or intranasally or anti-IL-6-treated mice, showed greatly reduced 50% lethal doses compared to wild-type (WT) mice. Increased susceptibility was not due to altered splenic immune cell populations during infection or decreased serum antibody production, as IL-6 KO mice had similar compositions of each compared to WT mice. Although LVS-infected IL-6 KO mice produced much less serum amyloid A and haptoglobin (two acute-phase proteins) than WT mice, there were no other obvious pathophysiological differences between LVS-infected WT and IL-6 KO mice. IL-6 KO or WT mice that survived primary LVS infection also survived a high-dose LVS secondary challenge. Using an in vitro overlay assay that measured T cell activation, cytokine production, and abilities of primed splenocytes to control intracellular LVS growth, we found that IL-6 KO total splenocytes or purified T cells were slightly defective in controlling intracellular LVS growth but were equivalent in cytokine production. Taken together, IL-6 is an integral part of a successful immune response to primary LVS infection, but its exact role in precipitating adaptive immunity remains elusive. Infect Immun 2013 Feb; 81(2):585-97
Human xenograft osteosarcoma models with spontaneous metastasis in mice: clinical relevance and applicability for drug testing
Osteosarcoma cells derived from patients have been isolated and subsequently cultured for the past 35 years. To date though, there have been no major break-throughs in the development of a model for osteosarcoma that uses orthotopic implantation of human osteosarcoma cells and that closely emulates the clinical progression of this debilitating and fatal disease. Such a model is long overdue given the devastating demographics (second highest cause of cancer-related death in the paediatric age group) of the ailment and the lack of solid options for control, if not cure, for the disease, as it also is the most common primary tumour of bone. Only then can more robust R & D be undertaken in the search for efficacious anti-osteosarcoma agents. This review tackles this conundrum and lists the variety of models (that use human osteosarcoma cells) available and the types of studies performed with these