960 research outputs found

    Prediction of Mechanical Properties of Graphene Oxide Reinforced Aluminum Composites

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    Estimating the effect of graphene oxide (GO) reinforcement on overall properties of aluminum (Al) matrix composites experimentally is time-consuming and involves high manufacturing costs and sophisticated characterizations. An attempt was made in this paper to predict the mechanical properties of GO/Al composites by using a micromechanical finite element approach. The materials used for prediction included monolayer and multilayer GO layers distributed uniformly on the spherical Al matrix particles. The estimation was done by assuming that a representative volumetric element (RVE) represents the composite structure, and reinforcement and matrix were modeled as continuum. The load transfer between the GO reinforcement and Al was modeled using joint elements that connect the two materials. The numerical results from the finite element model were compared with Voigt model and experimental results from the GO/Al composites produced at optimized process parameters. A good agreement of numerical results with the theoretical models was noted. The load-bearing capacity of the Al matrix increased with the addition of GO layers, however, Young’s modulus of the GO/Al composites decreased with an increase in the number of layers from monolayer to 5 layers. The numerical results presented in this paper have demonstrated the applicability of the current approach for predicting the overall properties of composites

    EVALUATION OF MEDHOVIKAS, A HERBAL FORMULATION FOR ANTIDEPRESSANT ACTIVITY

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    Objective: The present study was conducted to evaluate the antidepressant activity of Medhovikas and its activity is compared with that of Imipramine and Mentat. The MAO-A and MAO-B levels were estimated by the Biochemical Method.Methods: There are several methods available to evaluate the antidepressant activity. In the present study the antidepressant activity is assessed using behavioural despair method such as Forced swim test (FST) in mice. Imipramine is used as a positive control in doses of 10mg/kg and 20mg/kg, Similar activity was also observed with Medhovikas in doses of 200 and 400mg/kg. Biochemical method in rats to estimate the levels of MAO-A and MAO-B, the biogenic amine 5-HT is oxidized by MAO to 5-hydrixy indole acetic acid (5-HIAA) as a major metabolite and is excreted in urine. Hence the reduction in the urinary 5-HIAA level from normal after treatment with the test compound was taken as a measure of it's MAO inhibitory action.Results : The antidepressant activity of 200 and 400mg/kg of Medhovikas was equivalent to that of 10 and 20mg/kg of imipramine respectively. It significantly reduced the duration of immobility indicating antidepressant activity. Significant decrease in brain MAO-A and MAO-B levels were observed which was determined by the Biochemical method.Conclusion: Antidepressant activity was probably shown by inhibiting MAO-A and MAO-B, There are several methods to detect the monoamine oxidaise inhibitor activity of substances. These methods are based on biochemical estimation of biogenic amines and /or their pharmacological responses. This shows that Medhovikas is a potential antidepressant and the probable mechanism of action is in interest for further investigation.Keywords: Antidepressant, Forced swim test, Imipramine,MAO-A & B, Medhovika and Menta

    PHARMACEUTICAL PROCESSING AND ANALYTICAL STUDY OF TRIVANGA BHASMA

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    Background: Rasashastra is a branch of Ayurvedic pharmaceutics, which deals with the conversion of metals & minerals into potent medicines. In Rasashastra, the metals like gold, silver, copper, iron, lead, tin, zinc etc. are converted in to Bhasma and are applied in therapeutics. Validity of this branch of science totally depends on the successful completion of the practical aspects with careful observations, and it becomes necessary to perform analytical studies to check the quality of the finished products. Hence, the present study was carried out to understand the pharmaceutical processing and to analyze the Trivanga Bhasma with the aid of classical tests and modern analytical tools.Materials & Methods: Trivanga Bhasma was prepared by subjecting the Vanga, Naga & Yashada to Samanya & Vishesha Shodhana, Jarana and Marana processes as per the classical references. Final product was then subjected to all the classical Bhasmaparikshas and also analyzed by adopting modern analytical techniques.Results & Conclusion: Yellow coloured Trivanga Bhasma which passed all the Bhasmaparikshas was obtained after seventeen Laghuputas. Percentile of tin, lead & zinc were noted

    Observation of sub-Poisson photon statistics in the cavity-QED microlaser

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    We have measured the second-order correlation function of the cavity-QED microlaser output and observed a transition from photon bunching to antibunching with increasing average number of intracavity atoms. The observed correlation times and the transition from super- to sub-Poisson photon statistics can be well described by gain-loss feedback or enhanced/reduced restoring action against fluctuations in photon number in the context of a quantum microlaser theory and a photon rate equation picture. However, the theory predicts a degree of antibunching several times larger than that observed, which may indicate the inadequacy of its treatment of atomic velocity distributions.Comment: 4 pages, 4 figure

    Additively Manufactured Carbon Fiber- Reinforced Thermoplastic Composite Mold Plates For Injection Molding Process

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    Polymer injection molding processes have been used to create high-volume parts quickly and efficiently. Injection molding uses mold plates that are traditionally made of very hard tool steels, such as P20 steel, which is extremely heavy and has very long lead times to build new molds. In this study, composite-based additive manufacturing (CBAM) was used to create mold plates using long-fiber carbon fiber and polyether ether ketone (PEEK). These mold plates were installed in an injection molding machine, and rectangular flat plates were produced using Lustran 348 acrylonitrile butadiene styrene (ABS). Tensile and flexural testing was performed on these parts as well as parts produced using traditional P20 steel mold plates with the same geometry to compare the performance of the different mold plates. The parts produced using the carbon fiber mold plates were within 5% of the tensile strength and 10% of the flexural strength of the traditionally manufactured parts. However, the parts produced using the carbon fiber mold plates required additional cooling time due to the lower conductivity of the carbon fiber composite compared to the P20 steel. This allows additively manufactured composite molds to be a good substitute for conventional molds in low-volume injection molding production
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