4,168 research outputs found
Anxiety: An Evolutionary Approach
Anxiety disorders are among the most common mental illnesses, with huge attendant suffering. Current treatments are not universally effective, suggesting that a deeper understanding of the causes of anxiety is needed. To understand anxiety disorders better, it is first necessary to understand the normal anxiety response. This entails considering its evolutionary function as well as the mechanisms underlying it. We argue that the function of the human anxiety response, and homologues in other species, is to prepare the individual to detect and deal with threats. We use a signal detection framework to show that the threshold for expressing the anxiety response ought to vary with the probability of threats occurring, and the individual's vulnerability to them if they do occur. These predictions are consistent with major patterns in the epidemiology of anxiety. Implications for research and treatment are discussed
How to realize a robust practical Majorana chain in a quantum dot-superconductor linear array
Semiconducting nanowires in proximity to superconductors are promising
experimental systems for Majorana fermions, which may ultimately be used as
building blocks for topological quantum computers. A serious challenge in the
experimental realization of the Majorana fermions is the supression of
topological superconductivity by disorder. We show that Majorana fermions
protected by a robust topological gap can occur at the ends of a chain of
quantum dots connected by s-wave superconductors. In the appropriate parameter
regime, we establish that the quantum dot/superconductor system is equivalent
to a 1D Kitaev chain, which can be tuned to be in a robust topological phase
with Majorana end modes even in the case where the quantum dots and
superconductors are both strongly disordered. Such a spin-orbit coupled quantum
dot - s-wave superconductor array provides an ideal experimental platform for
the observation of non-Abelian Majorana modes.Comment: 8 pages; 3 figures; version 2: Supplementary material updated to
include more general proof for localized Majorana fermion
Impact of health behaviours and deprivation on well-being in a national sample of English young people
Objective: To determine the modifiable factors influencing well-being in boys and girls by accounting for deprivation, ethnicity and clustering within local authorities. Methods: We used data from a very large nationally representative survey, the What About Youth study involving 120 115 adolescents aged 15 years. Our outcome measure of mental well-being was the Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS). Potential explanatory factors included substance abuse, screen time, eating habits, reading, bullying, sleeping pattern, physical activity and area-level deprivation. We ran unadjusted and adjusted multilevel models for each explanatory factor, after adjusting for ethnicity, deprivation and including a random effect for the local authority. Results: Boys had a higher overall mean WEMWBS score than girls (p<0.0001). In the adjusted model, each of multiple risk behaviours, eating habits, sleep, bullying, physical activity, screen-time and reading were independently associated with mental well-being in both boy and girls (p<0.0001 for both). Sleep and eating behaviours had a stronger association in both sexes than bullying, physical activity and screen time. Young people from black ethnic groups had significantly higher well-being in both sexes. Deprivation was not associated with well-being among boys but was among girls. Conclusion: The largest contributors to adolescent well-being appear to be sleep, eating behaviours and bullying when considered in a multivariable framework. While adolescents from black ethnic groups had higher overall well-being scores, area deprivation did not affect male well-being but had a small effect on female well-being. Future longitudinal studies and health policies need to consider a range of behavioural factors to drive improvements in adolescent well-being
Primary Care Atrial Fibrillation Service: outcomes from consultant-led anticoagulation assessment clinics in the primary care setting in the UK
OBJECTIVE: Stroke-risk in atrial fibrillation (AF) can be significantly reduced by appropriate thromboembolic prophylaxis. However, National Institute for Health and Care Excellence estimates suggest that up to half of eligible patients with AF are not anticoagulated, with severe consequences for stroke prevention. We aimed to determine the outcome of an innovative Primary Care AF (PCAF) service on anticoagulation uptake in a cohort of high-risk patients with AF in the UK. METHODS: The PCAF service is a novel cooperative pathway providing specialist resources within general practitioner (GP) practices. It utilises a four-phase protocol to identify high-risk patients with AF (CHA(2)DS(2)-VASc ≥1) who are suboptimally anticoagulated, and delivers Consultant-led anticoagulation assessment within the local GP practice. We assessed rates of anticoagulation in high-risk patients before and after PCAF service intervention, and determined compliance with newly-initiated anticoagulation at follow-up. RESULTS: The PCAF service was delivered in 56 GP practices (population 386 624; AF prevalence 2.1%) between June 2012 and June 2014. 1579 high-risk patients with AF with suboptimal anticoagulation (either not taking any anticoagulation or taking warfarin but with a low time-in-therapeutic-range) were invited for review, with 86% attending. Of 1063 eligible patients on no anticoagulation, 1020 (96%) agreed to start warfarin (459 (43%)) or a non-vitamin K antagonist oral anticoagulant (NOAC, 561 (53%)). The overall proportion of eligible patients receiving anticoagulation improved from 77% to 95% (p<0.0001). Additionally, 111/121 (92%) patients suboptimally treated with warfarin agreed to switch to a NOAC. Audit of eight practices after 195 (185–606) days showed that 90% of patients started on a new anticoagulant therapy had continued treatment. Based on data extrapolated from previous studies, around 30–35 strokes per year may have been prevented in these previously under-treated high-risk patients. CONCLUSIONS: Systematic identification of patients with AF with high stroke-risk and consultation in PCAF consultant-led clinics effectively delivers oral anticoagulation to high-risk patients with AF in the community
Lifshitz spacetimes from AdS null and cosmological solutions
We describe solutions of 10-dimensional supergravity comprising null
deformations of with a scalar field, which have
Lifshitz symmetries. The bulk Lifshitz geometry in 3+1-dimensions arises by
dimensional reduction of these solutions. The dual field theory in this case is
a deformation of the N=4 super Yang-Mills theory. We discuss the holographic
2-point function of operators dual to bulk scalars. We further describe
time-dependent (cosmological) solutions which have anisotropic Lifshitz scaling
symmetries. We also discuss deformations of in 11-dimensional
supergravity, which are somewhat similar to the solutions above. In some cases
here, we expect the field theory duals to be deformations of the Chern-Simons
theories on M2-branes stacked at singularities.Comment: Latex, 29pgs, v3. references, minor clarifications (subsection on
Lifshitz geometry seen by scalar probes) added, to appear in JHE
Thermal quenches in N=2* plasmas
We exploit gauge/gravity duality to study `thermal quenches' in a plasma of
the strongly coupled N=2* gauge theory. Specifically, we consider the response
of an initial thermal equilibrium state of the theory under variations of the
bosonic or fermionic mass, to leading order in m/T<<1. When the masses are made
to vary in time, novel new counterterms must be introduced to renormalize the
boundary theory. We consider transitions the conformal super-Yang-Mills theory
to the mass deformed gauge theory and also the reverse transitions. By
construction, these transitions are controlled by a characteristic time scale
\calt and we show how the response of the system depends on the ratio of this
time scale to the thermal time scale 1/T. The response shows interesting
scaling behaviour both in the limit of fast quenches with T\calt<<1 and slow
quenches with T\calt>>1. In the limit that T\calt\to\infty, we observe the
expected adiabatic response. For fast quenches, the relaxation to the final
equilibrium is controlled by the lowest quasinormal mode of the bulk scalar
dual to the quenched operator. For slow quenches, the system relaxes with a
(nearly) adiabatic response that is governed entirely by the late time profile
of the mass. We describe new renormalization scheme ambiguities in defining
gauge invariant observables for the theory with time dependant couplings.Comment: 78 pages, 17 figure
Lessons to be learnt from Leishmania studies
Leishmaniasis is a disease caused by infection with the protozoan parasite Leishmania, which is responsible for three main types of disease: cutaneous leishmaniasis, visceral leishmaniasis and mucocutaneous leishmaniasis based to the site of infection for the particular species. This presents a major challenge to successful drug treatment, as a drug must not only reach antileishmanial concentrations in infected macrophages, the parasites' host cell, but also reach infected cells in locations specific to the type of disease. In this paper we discuss how studies using Leishmania have contributed to our knowledge on how drug delivery systems can be used to improve drug efficacy and delivery
How managers can build trust in strategic alliances: a meta-analysis on the central trust-building mechanisms
Trust is an important driver of superior alliance performance. Alliance managers are influential in this regard because trust requires active involvement, commitment and the dedicated support of the key actors involved in the strategic alliance. Despite the importance of trust for explaining alliance performance, little effort has been made to systematically investigate the mechanisms that managers can use to purposefully create trust in strategic alliances. We use Parkhe’s (1998b) theoretical framework to derive nine hypotheses that distinguish between process-based, characteristic-based and institutional-based trust-building mechanisms. Our meta-analysis of 64 empirical studies shows that trust is strongly related to alliance performance. Process-based mechanisms are more important for building trust than characteristic- and institutional-based mechanisms. The effects of prior ties and asset specificity are not as strong as expected and the impact of safeguards on trust is not well understood. Overall, theoretical trust research has outpaced empirical research by far and promising opportunities for future empirical research exist
A road to reality with topological superconductors
Topological states of matter are a source of low-energy quasiparticles, bound
to a defect or propagating along the surface. In a superconductor these are
Majorana fermions, described by a real rather than a complex wave function. The
absence of complex phase factors promises protection against decoherence in
quantum computations based on topological superconductivity. This is a tutorial
style introduction written for a Nature Physics focus issue on topological
matter.Comment: pre-copy-editing, author-produced version of the published paper: 4
pages, 2 figure
Non-Abelian statistics and topological quantum information processing in 1D wire networks
Topological quantum computation provides an elegant way around decoherence,
as one encodes quantum information in a non-local fashion that the environment
finds difficult to corrupt. Here we establish that one of the key
operations---braiding of non-Abelian anyons---can be implemented in
one-dimensional semiconductor wire networks. Previous work [Lutchyn et al.,
arXiv:1002.4033 and Oreg et al., arXiv:1003.1145] provided a recipe for driving
semiconducting wires into a topological phase supporting long-sought particles
known as Majorana fermions that can store topologically protected quantum
information. Majorana fermions in this setting can be transported, created, and
fused by applying locally tunable gates to the wire. More importantly, we show
that networks of such wires allow braiding of Majorana fermions and that they
exhibit non-Abelian statistics like vortices in a p+ip superconductor. We
propose experimental setups that enable the Majorana fusion rules to be probed,
along with networks that allow for efficient exchange of arbitrary numbers of
Majorana fermions. This work paves a new path forward in topological quantum
computation that benefits from physical transparency and experimental realism.Comment: 6 pages + 17 pages of Supp. Mat.; 10 figures. Supp. Mat. has doubled
in size to establish results more rigorously; many other improvements as wel
- …