Investigating the radial flow like effects using identified triggered correlation in pp collisions at s\sqrt{s} = 7 TeV

An inclusive baryon to meson enhancement with increase in multiplicity has been observed in pp collisions at $\sqrt{s}$= 7 TeV. Such a striking feature of the data can be explained by approaches based on hydrodynamics and multi-parton interactions (MPI) coupled with color reconnection (CR) mechanism. In this paper, we investigate the multiplicity evolution of the charged particle yields associated with pions and protons selected from the intermediate $p_{T}$ region where the inclusive baryon to meson enhancement has been observed. The study has been peformed using EPOS 3 (hydrodynamics) and PYTHIA 8 (MPI with CR) event generators in pp collisions at 7 TeV. We find that the response of the individual pion and proton triggered correlation towards these two mechanisms is different and can be used to disentangle the effect of one from the other. The current study can, therefore, provide important insights on the origin of radial flow like effects in high multiplicity pp collisions at the LHC energies.Comment: 5 pages, 6 figure

ANTIMICROBIAL INVESTIGATION AND BINDING MODE ANALYSIS OF SOME NEWLY SYNTHESIZED 4-AMINO-5-((ARYL SUBSTITUTED)-4H-1, 2, 4-TRIAZOLE-3-YL)-THIO LINKED HYDROXAMIC ACID DERIVATIVES

Objective: A series of 5-substituted-4-amino-1, 2, 4-triazole-linked hydroxamic acid derivatives have been synthesized and explored in vitro to evaluate antibacterial and antifungal activities. Methods: Different 5-phenyl group substituted-4-amino-1,2,4-triazole-3-thiol reacted with chlorine substituted hydroxamic acid to produce the desired compounds and characterized spectroscopically. Minimum inhibitory concentration (MIC), zone of inhibition (ZOI), growth kinetic studies, and scanning electron microscopy (SEM) were employed to elicit the antimicrobial efficacy of synthesized compounds against a wide range of bacterial and fungal strains. Results: Compounds 6a, 6b, 6d, and 6k (MIC of 25 μg/ml) have been found to be more potent against Klebsiella pneumoniae, Bacillus cereus, Bacillus pumilus, Micrococcus luteus, and Pseudomonas aeruginosa, compounds 6a-6d, 6k, and 6l (MIC of 25–50 μg/ml) have shown potent antibacterial efficacy against Klebsiella pneumonia, P. aeruginosa, and Vibrio cholera compare to the standard drug amoxicillin (MIC of 60 μg/ml, 65 μg/ml, and 25 μg/ml, respectively). Screening for the antifungal activity revealed that the compounds were found to be most active against Candida albicans (6a, 6b, and 6l), Candida tropicalis (6b and 6d), and Aspergillus niger (6a, 6b, 6d, and 6j) with MIC of 15–25 μg/ml. Bacteriostatic and fungistatic effect of titled compounds was revealed from growth kinetics study. Conclusion: Electron donating group at the 5-position of the 5-substituted-1,2,4-triazole-linked hydroxamic acid derivatives conferred the biological effectiveness of the synthesized compounds and also offer a therapeutically effective prototypical structure for further development of new chemical entities with superior antimicrobial activity

ENDORSEMENT OF SMALL PATIENTS POPULATION STUDY THROUGH DATA MINING CLASSIFICATION: SIGNIFICANCE TO MANIFEST DRUG INTERACTION STUDY OF CARDIOVASCULAR DOSAGE FORMULATION

Objective: A simple, sensitive, precise computational classifiers justifies the positive indication of drug interaction through statistical validation and confirms for further root level investigation. Methods: The blood pressure (BP) & Lipid profile valued data sheet was prepared from 100 patients those were chronically treating with cardiovascular formulation consisting Atorvastatin 10mg + Olmesartan 20mg. The data sheet contains 100 patients with 10 variables and final decision attributes of working & non-working. Then, with the operation of seven different related classifier the details of % of accuracy by class, correct & incorrect classified instance and stratified cross- validation were estimated. Those statistical results of classifiers were compared, correlate and interpreted to bring a fixed conclusion based on it. Results: The % of accuracy for all classifiers results commonly 95.9596 %, 93.9394 % and 96.9697 % and inter-depending class attributes denoting by a = NW & b =W Matrix values are 84│11, 84│9, 87│9 respectively. Thus, the accuracy is excellent covering within the limits of (±15%) as a correct classified instant. Conclusion: Statistical computation on less populated patients through classifiers, evidentially confirms the drug-interaction profile of collected data through data mining process. So that, it can proceeds further upto root level through instrumental bioanalysis. Â&nbsp

Fuzzy multi-criteria group decision making approach for grading of mulberry silk cocoons

A multi-criteria group decision making method has been applied for grading of silk cocoons which employs the proficiency of three experts as decision makers to alleviate the fuzziness underlying in silk cocoon parameters. Fuzzy-TOPSIS approach of multi-criteria group decision making method has been used in this study. Four quality parameters of silk cocoon, viz. good cocoon percentage, cocoon weight, cocoon size and compactness are regarded as criteria. The 10 cocoon lots are ranked based on Fuzzy-TOPSIS method. The ranking of cocoon lots attained by this method shows a significant agreement with the ranks devised by the sericulture experts

Recombinant Hormones: Applications And Challenges

Recombinant DNA technology has brought about a revolutionary transformation in the production of medical hormones. This comprehensive review paper presents an overview of the fundamental principles underlying recombinant DNA technology and its significant applications in hormone production. The discussion encompasses the production of various recombinant hormones, including human growth hormone, infertility treatment hormones, menopause and osteoporosis control hormones, and insulin. The paper delves into the challenges associated with recombinant hormone production, emphasizing the importance of meticulous optimization of expression systems and addressing potential contamination concerns. Furthermore, the review explores the utilization of recombinant hormones in medical research, contributing to the development of diagnostic and therapeutic protocols. Ethical considerations and safety concerns related to the use of recombinant hormones are also addressed, emphasizing the imperative need for stringent regulation in this rapidly advancing field. This paper provides a comprehensive and plagiarism-free exploration of the multifaceted aspects of recombinant DNA technology and its pivotal role in advancing hormone production for medical application

Recombinant Protein Production: Advancements And Applications

Recombinant gene production has become a cornerstone of modern biotechnology, offering revolutionary solutions in various fields. This abstract explores the diverse applications of recombinant gene technology, highlighting its pivotal role in medicine, agriculture and industry, while also discussing the latest advancements and challenge. Recombinant gene production involves the deliberate manipulation of genetic material to create hybrid DNA sequences with desired traits. This technology has enabled the synthesis of therapeutic proteins, vaccines and enzymes that were once scarce or inaccessible. In medicine recombinant gene expression systems have revolutionized the treatment of various diseases, ranging from insulin production for diabetesb management to monoclonal antibody therapies for cancer treatment. In agriculture, recombinant gene technology has been harnessed to develop genetically modified crops with enhanced nutritional content, resistance to pests and diseases and improve yield. These advancements hold promise for addressing global food security challenges, although they also raise concerns about ecological impact and consumeracceptance. Industrial applications of recombinant gene production encompass the production of biofuels, bioplastics and wide array of biobased chemicals. This technology enables the cost effective production of valuable compounds through microbial fermentation or other bioprocesses, contributing to sustainable manufacturing practices. Recent advancements in recombinant gene production include the development of novel expression systems such as synthetic biology tools that enable precise control over gene expression and metabolic pathways. Additionally, innovations like CRISPR based genome editing have accelerated the modification of host organisms for improved recombinant protein yields and functionalities. Despite its transformative potential, recombinant gene production faces challenges. Ensuring the safety and regulatory compliance of genetically modified products remain a priority. Furthermore, optimising expression systems to maximize yields, scalability, and post translational modifications is ongoing endeavou