Effects of Phase Transition induced density fluctuations on pulsar dynamics

We show that density fluctuations during phase transitions in pulsar cores may have non-trivial effects on pulsar timings, and may also possibly account for glitches and anti-glitches. These density fluctuations invariably lead to non-zero off-diagonal components of the moment of inertia, leading to transient wobbling of star. Thus, accurate measurements of pulsar timing and intensity modulations (from wobbling) may be used to identify the specific pattern of density fluctuations, hence the particular phase transition, occurring inside the pulsar core. Changes in quadrupole moment from rapidly evolving density fluctuations during the transition, with very short time scales, may provide a new source for gravitational waves.Comment: 9 pages, 1 figure. arXiv admin note: substantial text overlap with arXiv:1412.427

Looking for a heavy wino LSP in collider and dark matter experiments

We investigate the phenomenology of a wino LSP as obtained in AMSB and some string models. The WMAP constraint on the DM relic density implies a wino LSP mass of 2.0-2.3 TeV. We find a viable signature for such a heavy wino at CLIC, operating at its highest CM energy of 5 TeV. One also expects a viable monochromatic $\gamma$-ray signal from its pair-annihilation at the galactic centre at least for cuspy DM halo profiles.Comment: A discussion on non-perturbative effects on annihilation cross section of TeV scale wino LSP added. Version to appear in Phys. Rev. D

Real Time Power System and Sub Synchronous Inter Harmonics

Real time Power system is associated with different types of abnormalities which percolate into the system thus generating various spurious signals, which ultimately results in massive breakdown of the same. In this scope of work, we have intended to design a real time power system using MATLAB (Version7.8.0.347) (R2009a) and incorporating Continuous Wavelet Transform and also we have developed a program for effective identification of sub-harmonics, generated or carried into the system due to the power system behavioral nature

Methylation mediated silencing of TMS1/ASC gene in prostate cancer

BACKGROUND: Transcriptional silencing associated with aberrant promoter methylation has been established as an alternate pathway for the development of cancer by inactivating tumor suppressor genes. TMS1 (Target of Methylation induced Silencing), also known as ASC (Apoptosis Speck like protein containing a CARD) is a tumor suppressor gene which encodes for a CARD (caspase recruitment domain) containing regulatory protein and has been shown to promote apoptosis directly and by activation of downstream caspases. This study describes the methylation induced silencing of TMS1/ASC gene in prostate cancer cell lines. We also examined the prevalence of TMS1/ASC gene methylation in prostate cancer tissue samples in an effort to correlate race and clinico-pathological features with TMS1/ASC gene methylation. RESULTS: Loss of TMS1/ASC gene expression associated with complete methylation of the promoter region was observed in LNCaP cells. Gene expression was restored by a demethylating agent, 5-aza-2'deoxycytidine, but not by a histone deacetylase inhibitor, Trichostatin A. Chromatin Immunoprecipitation (ChIP) assay showed enrichment of MBD3 (methyl binding domain protein 3) to a higher degree than commonly associated MBDs and MeCP2. We evaluated the methylation pattern in 66 prostate cancer and 34 benign prostatic hyperplasia tissue samples. TMS1/ASC gene methylation was more prevalent in prostate cancer cases than controls in White patients (OR 7.6, p 0.002) while no difference between the cases and controls was seen in Black patients (OR 1.1, p 0.91). CONCLUSION: Our study demonstrates that methylation-mediated silencing of TMS1/ASC is a frequent event in prostate cancer, thus identifying a new potential diagnostic and prognostic marker for the treatment of the disease. Racial differences in TMS1/ASC methylation patterns implicate the probable role of molecular markers in determining in susceptibility to prostate cancer in different ethnic groups