63 research outputs found
Camylofin in the management of prolonged labor: a review of evidence
Prolonged labor can lead to increased maternal and neonatal morbidity and mortality. Hence, it warrants an early detection and appropriate clinical management. Active management of labor has shown to decrease the occurrence of prolonged labor. Administering antispasmodics during labor facilitates a faster and more effective dilatation of the cervix. Hence, antispasmodics can be used to decrease the incidence of prolonged labor. Camylofin, a potent antispasmodic, with a dual mode of action, has been used in the augmentation of labor for more than six decades. There is a growing body of evidence to support the efficacy and tolerability of Camylofin in the active management of labor. A review of published evidence suggests that Camylofin has superior efficacy in augmentation of labor on multiple counts like rate of cervical dilation, duration of active phase of first stage of labor and induction delivery interval, when compared to other spasmolytics like drotaverine, hyoscine and valethemate. It also has a benefit of a convenient single dose as compared to the other spasmolytics listed earlier. Camylofin has other advantages like a quick onset of action, prolonged action, no adverse effects on uterine contractility, no contraindication for use in uterine inertia cases and overall good tolerability for both mother and fetus. Given the superior efficacy and benefits that this drug exhibits, coupled with its excellent tolerability profile, Camylofin should be the first choice and may be preferred over other drugs for cervical dilatation and acceleration of active phase of labor
Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists
Impact of Induction Therapy on Clinical Outcomes of Kidney Transplant Recipients: A Single-Centre Cohort Study
The purpose of this study was to evaluate long-term efficacy of immunosuppressive drugs based on the type of induction therapy given to kidney transplant recipients, and determine the occurrence of graft dysfunctions or rejections. We compared the safety and efficacy of anti-thymocyte globulin (ATG) and basiliximab (BAS) in high-risk patients and analyzed the cumulative incidence of immediate, slow, and delayed graft function in kidney transplant recipients to determine their initial short-term graft function. Evaluation of the long-term efficacy after 3 years post-transplantation by assessment of patients and graft survival, incidence of infections, and risks of rejection were the primary endpoints. Patients with stable graft survival were observed more with ATG (85%) than BAS (70%); in contrast, graft dysfunctions, graft nephrectomy, rejection episodes, and patient deaths were more prevalent with BAS than ATG, with statistically significant differences in long-term graft functioning. Patient survival at 3 years in ATG group was 90.4%, compared to 88% in BAS group, and graft survival was 90.4% in the ATG group and 81.3% in the BAS group (P < 0.001). The use of both induction therapies resulted in good patient and graft survival outcomes than placebo, and the results showed that there was a significant difference in both patient and graft survival after 3 years between induction of ATG and BAS, suggesting that ATG can be safer, effective, and preferable drug over BAS for high-risk recipients
Supporting Information: Unexpected chain of redox events in co-based Prussian blue analogues
Comprehensive characterizing information about the series of materials; crystal, composition, and hyperfine parameters of the 57Fe Mössbauer spectra of samples K2−δMn1–xCox[Fe(CN)6]; SAED and TGA patterns, HAADF-STEM images, ATR–FTIR, 57Fe Mössbauer spectra, and electrochemical galvanostatic profiles of the mentioned series of samples; calculated fit of XAS experiments; and plots of KCMF50 and KCF operando SXRD in a 10–54° 2Θ range (λ = 1.0332 Å).Peer reviewe
Not Available
Not AvailablePhytic acid (PA) is an important antinutritional
component in maize that affects the availability
of major micro-nutrients like di- and multivalent
mineral cations like iron (Fe) and zinc (Zn).
The long-term consumption of maize as a staple food
crop leads to micronutrient malnutrition especially
iron and zinc deficiency in the human population. In
addition, it also acts as a storehouse of a major part of
mineral phosphorous (P), approximately 80% of the
total P stored as phytate P is not available to monogastric
animals like humans and poultry birds, and it gets excreted as such, leading to one of the major
environmental pollution called eutrophication. Of the
various low phytic acid (lpa) mutants, lpa2-2 generated
through mutagenesis reduces PA by 30%. BML 6
and BML 45, the parents of the popular maize hybrid
DHM 121 with high PA were selected to introgress
lpa2-2 through marker-assisted backcross breeding
(MABB). The percent recurrent parental genome
(RPG) in the selected BC2F2
plants ranged from 88.68
to 91.04% and 90.09–91.51% in the genetic background
of BML 6 and BML 45, respectively. Based
on the highest percentage of RPG, best five BC2F2
plants, viz., #3190, #3283, #3230, #3263 and #3292
with RPG 88.68–91.04% in the genetic background of
BML 6 and #3720, #3776, #3717, #3828 and #3832
with RPG 90.09–91.51% in the genetic background
of BML 45 were advanced to BC2F3.
The newly
developed near-isogenic lines (NILs) possessed low
phytate content (2.37 mg/g in BML 6 and 2.40 mg/g
in BML 45) compared to 3.59 mg/g and 3.16 mg/g in
recurrent parents BML 6 and BML 45, respectively
thereby reducing the phytate by an average of 34 and
24 per cent, respectively. These newly developed
progenies were similar to their recurrent parents for
various morphological traits. These inbreds assume
great significance in alleviating Fe and Zn deficiencies
in worldwide.Not Availabl
Neutron emission from electromagnetic dissociation of Pb nuclei at √ s NN = 2.76 TeV measured with the ALICE ZDC
The ALICE Zero Degree Calorimeter system (ZDC) is composed of two identical sets of calorimeters, placed at opposite sides with respect to the interaction point, 114 meters away from it, complemented by two small forward electromagnetic calorimeters (ZEM). Each set of detectors consists of a neutron (ZN) and a proton (ZP) ZDC. They are placed at zero degrees with respect to the LHC axis and allow to detect particles emitted close to beam direction, in particular neutrons and protons emerging from hadronic heavy-ion collisions (spectator nucleons) and those emitted from electromagnetic processes. For neutrons emitted by these two processes, the ZN calorimeters have nearly 100% acceptance. During the √ sNN = 2.76 TeV Pb-Pb data-taking, the ALICE Collaboration studied forward neutron emission with a dedicated trigger, requiring a minimum energy deposition in at least one of the two ZN. By exploiting also the information of the two ZEM calorimeters it has been possible to separate the contributions of electromagnetic and hadronic processes and to study single neutron vs. multiple neutron emission. The measured cross sections of single and mutual electromagnetic dissociation of Pb nuclei at √ s NN = 2.76 TeV, with neutron emission, are σ single EMD = 187:4 ± 0.2 (stat.)-11.2 +13.2 (syst.) b and σmutual EMD = 5.7 ± 0.1 (stat.) ±0.4 (syst.) b, respectively [1]. This is the first measurement of electromagnetic dissociation of 208Pb nuclei at the LHC energies, allowing a test of electromagnetic dissociation theory in a new energy regime. The experimental results are compared to the predictions from a relativistic electromagnetic dissociation model'701st International Conference on New Frontiers in Physics, ICFP 20122012-06-10Kolymbari, Crete; Greecesem informaçã
Design of a constrained high data rate CDMA system
This paper deals with the design of a high data rate code-division multiple-access (CDMA) system under a speci¯ed jamming mar- gin speci¯cation as well as hardware and band-width limitations. Several choices had to be made
in coming up with the design such as specify-ing the number of subcarriers, choice of spread-ing codes and the nature of the modulation.The rationale behind each of the choices made is given. Descriptions of transmitter and receiver are also included. Relevant simulations of cross-correlation are also provided
Role of Individual Bands in the Unusual Temperature-Dependent Band Gap of Methylammonium Lead Iodide
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