Maternal and perinatal outcomes in diabetic pregnancies at BPKIHS

Background: Diabetes has become a global pandemic because of aging population, sedentary life style, urbanization, and increasing incidence of obesity; this study was aimed to identify the maternal and perinatal outcome in Diabetes complicating pregnancies and to compare the outcome in Gestational Diabetes Mellitus and Overt Diabetes Mellitus.Methods: This was a descriptive study conducted from 1st April 2013-31st March 2014 on total 75 pregnant women. All antenatally diagnosed cases of GDM and overt diabetes, booked or unbooked, whoever came for delivery were studied. Both mothers and neonates were followed up in ante-partum, intra-partum, and post-partum period till their stay in hospital. Management of the patient was done as per the hospital protocol.Results: Out of 75 cases enrolled, 25.33% had GDM and 16% had overt diabetes mellitus.57.33%patients were multigravida, among which 40% had GDM and 17.33% had Overt Diabetes Mellitus.61.33% patients underwent LSCS, of which 41.33% had GDM and 20% had overt diabetes mellitus. Obstetric complication was more common in GDM patients (30.66%) compared to Overt (22.66%). 89.33%babies had good neonatal outcome and 10.66% babies (6.66% of GDM mothers and 4% of overt mothers) had poor neonatal outcome (macrosomia, hypoglycaemia, prematurity, respiratory distress with NICU stay and use of antibiotics, poor APGAR (<7 at 5 min), gross congenital malformation, hyperbilirubinemia, stillbirth and neonatal death).Conclusions: Maternal and perinatal complications was commonly seen in diabetic pregnancy though more common in GDM.The time has come for the Government of Nepal to implement an effective plan to the benefit of pregnant women with diabetes during pregnancy

Present Status of Massive Open Online Course (MOOC) initiatives for Open Education Systems in India – An Analytical Study

This paper highlights the MOOC initiatives in open access education environment across a globe with special reference to India. Open education resourses, open access, online open courseware are the main components to promote open university with the help of MOOC platform by the various service providers. MOOC List is open access (OA) aggregator (directory) of Massive Open Online Courses (MOOCs) from different providers. MOOC List is a website where you can find free online courses (MOOCs) offered by the best universities around the world. For this purpose, MOOC List directory was studied to find their growth rate, country, subject-wise distribution as well as total courses available in Indian education systems in MOOC within verious MOOC platforms

DRONE DISCOVERY PROTOCOL FOR ENTERPRISE DRONES VIA SMART CONTRACTS

Techniques are described herein for targeting the Enterprise drone market where the authorization and traceability of unmanned drones for service deliveries will be necessary in the near future. Currently, the implementation of drone tracking and its end to end flight validation is still poorly defined. Therefore, a consensus mechanism tying all entities within the drone ecosystem is needed (e.g., the manufacturer, insurance companies, smart city authorities, traffic controller, etc.). Described within is a consensus based smart contract using blockchain technology within the drone application which makes it permissible to fly and be tracked by a drone discovery protocol

Traumatic avulsion of the eyeball: a case report

Ocular trauma is very common, but globe avulsion along with optic nerve avulsion is a rare clinical event. Blunt trauma during a road traffic accident can cause rupture or avulsion of the globe and the outcome can range from complete recovery on repositioning to visual loss because of globe perforation or optic nerve injury. Here, authors report a case of a 20-year-old male who presented with history of a road traffic accident causing severe facial injuries. The physical examination revealed oedema and ecchymoses over the right side of the face with avulsion of the right eyeball anteriorly outside the orbit along with avulsion of the optic nerve. The visual acuity in the injured eye was no perception of light and the direct pupillary response was absent. Computed tomography revealed fracture of the roof and lateral wall of the right orbit. As the eye was not salvageable, enucleation surgery was done. Insertion of an ocular prosthesis for rehabilitation was planned. The presentation, investigations, surgery and follow-ups are described

Dirhenium Carbonyl Complexes Bearing 2-Vinylpyridine, Morpholine and 1-Methylimidazole Ligands

Treatment of the labile compound [Re2(CO)8(MeCN)2] with 2-vinylpyridine in refluxing benzene affords exclusively the new compound [Re2(CO)8(μ-η1:η2-NC5H4CHCH2)] (1) in 39% yield in which the μ-η1:η2-vinylpyridine ligand is coordinated to one Re atom through the nitrogen and to the other Re atom via the olefinic double bond. Reaction of [Re2(CO)8(MeCN)2] with morpholine in refluxing benzene furnishes two compounds, [Re2(CO)9(η1-NC4H9O)] (2) and [Re2(CO)8(η1-NC4H9O)2] (3) in 5% and 29% yields, respectively. Reaction of [Re2(CO)8(MeCN)2] with 1-methylimidazole gives [Re2(CO)8{η1-NC3H3N(CH3)}2] (4) and the mononuclear compound fac-[ReCl(CO)3{η1-NC3H3N(CH3)}2] (5) in 18% and 26% yields, respectively. In the disubstituted compounds 2 and 4, the heterocyclic ligands occupy equatorial coordination sites. The mononuclear compound 5 consists of three CO groups, two N coordinated η1-1-methylimidazole ligands and a terminal Cl ligand. The XRD structures of complexes 1, 3 and 5 are reported

Periorbital necrotizing fasciitis in a case of lid and conjunctival amyloidosis

Necrotizing fasciitis is a severe, progressive, rapidly spreading infection of the subcutaneous soft tissue and underlying fascia. Periorbital necrotizing fasciitis is rare owing to the excellent blood supply of the area. Ocular amyloidosis is relatively uncommon- that of the eyelid is typically associated with systemic associations whereas amyloidosis of the conjunctiva is often localised with no other associations. Authors report a case of a 40-year-old female with a 4-year history of eyelid and conjunctival amyloidosis who presented with necrotic ulcers and eschars in the upper and lower lid with purulent discharge, conjunctival mass and a dry looking cornea in the left eye. She was a known case of rheumatoid arthritis (RA) on treatment in the last 2 years. The presentation, investigations and management are described.

EFFECT OF ULTRA-DILUTED HISTAMINE ON HYPOXIC CHICK LUNG TISSUE INFLAMMATORY CHANGES

Objectives: Since its discovery, the role of histamine in inflammation is controversial; thus, according to some authority, it is mainly pro-inflammatory, and according to others, it is anti-inflammatory in nature. In this scenario, we thought that the contradictory results are dose dependent, thus in this study, our aim was to find the specific role of ultra-diluted histamine in pulmonary inflammation. Materials and Methods: Ultra-diluted histamine ( ~1 pg/ml) was administered in chick lung hypoxic inflammation in an restricted organoid culture along with lysozyme, ovalbumin, and blank controls. Results: The ultra-diluted histamine showed a significant role as an anti-inflammatory and bronchodilator agent and the anti-inflammatory action was found similar to lysozyme. Conclusion: Ultra-diluted histamine may be used as an anti-inflammatory agent

Reactivity of [Re\u3csub\u3e2\u3c/sub\u3e(CO)\u3csub\u3e8\u3c/sub\u3e(MeCN)\u3csub\u3e2\u3c/sub\u3e] with Thiazoles: Hydrido Bridged Dirhenium Compounds Bearing Thiazoles in Different Coordination Modes

Reactions of the labile compound [Re2(CO)8(MeCN)2] with thiazole and 4-methylthiazole in refluxing benzene afforded the new compounds [Re2(CO)7{μ-2,3-η2-C3H(R)NS}{η1-NC3H2(4-R)S}(μ-H)] (1, R = H; 2, R = CH3), [Re2(CO)6{μ-2,3-η2-C3H(R)NS}{η1-NC3H2(4-R)S}2(μ-H)] (3, R = H; 4, R = CH3) and fac-[Re(CO)3(Cl){η1-NC3H2(4-R)S}2] (5, R = H; 6, R = CH3). Compounds 1 and 2 contain two rhenium atoms, one bridging thiazolide ligand, coordinated through the C(2) and N atoms and a η1-thiazole ligand coordinated through the nitrogen atom to the same Re as the thiazolide nitrogen. Compounds 3 and 4 contain a Re2(CO)6 group with one bridging thiazolide ligand coordinated through the C(2) and N atoms and two N-coordinated η1-thiazole ligands, each coordinated to one Re atom. A hydride ligand, formed by oxidative-addition of C(2)–H bond of the ligand, bridges Re–Re bond opposite the thiazolide ligand in compounds 1–4. Compound 5 contains a single rhenium atom with three carbonyl ligands, two N-coordinated η1-thiazole ligands and a terminal Cl ligand. Treatment of both 1 and 2 with 5 equiv. of thiazole and 4-methylthiazole in the presence of Me3NO in refluxing benzene afforded 3 and 4, respectively. Further activation of the coordinated η1-thiazole ligands in 1–4 is, however, unsuccessful and results only nonspecific decomposition. The single-crystal XRD structures of 1–5 are reported

Surface-Enhanced Raman Scattering: Introduction and Applications

Scattering of light by molecules can be elastic, Rayleigh scattering, or inelastic, Raman scattering. In the elastic scattering, the photon’s energy and the state of the molecule after the scattering events are unchanged. Hence, Rayleigh scattered light does not contain much information on the structure of molecular states. In inelastic scattering, the frequency of monochromatic light changes upon interaction with the vibrational states, or modes, of a molecule. With the advancement in the laser sources, better and compact spectrometers, detectors, and optics Raman spectroscopy have developed as a highly sensitive technique to probe structural details of a complex molecular structure. However, the low scattering cross section (10−31) of Raman scattering has limited the applications of the conventional Raman spectroscopy. With the discovery of surface-enhanced Raman scattering (SERS) in 1973 by Martin Fleischmann, the interest of the research community in Raman spectroscopy as an analytical method has been revived. This chapter aims to familiarize the readers with the basics of Raman scattering phenomenon and SERS. This chapter will also discuss the latest developments in the SERS and its applications in various fields

Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages

Background: The search for molecules against Mycobacterium tuberculosis is urgent. The mechanisms facilitating the intra-macrophage survival of Mycobacterium tuberculosis are as yet not entirely understood. However, there is evidence showing the involvement of host cell cytoskeleton in every step of establishment and persistence of mycobacterial infection. Methodology/Principal Findings: Here we show that expression of ARPC4, a subunit of the Actin related protein 2/3 (Arp2/3) protein complex, severely affects the pathogen’s growth. TEM studies display shedding of the mycobacterial outer-coat. Furthermore, in infected macrophages, mycobacteria expressing ARPC4 were cleared off at a much faster rate, and were unable to mount a pro-inflammatory cytokine response. The translocation of ARPC4-expressing mycobacteria to the lysosome of the infected macrophage was also impaired. Additionally, the ARPC4 subunit was shown to interact with Rv1626, an essential secretory mycobacterial protein. Real-time PCR analysis showed that upon expression of ARPC4 in mycobacteria, Rv1626 expression is downregulated as much as six-fold. Rv1626 was found to also interact with mammalian cytoskeleton protein, Arp2/3, and enhance the rate of actin polymerization. Conclusions/Significance: With crystal structures for Rv1626 and ARPC4 subunit already known, our finding lays out the effect of a novel molecule on mycobacteria, and represents a viable starting point for developing potent peptidomimetics