Code for female backward iteration

Code for female backward iteratio

Code for male backwards iteration

Code for male backwards iteratio

Data for cohorts of 100 males and 100 females

Data for cohorts of 100 males and 100 female

Time-independent optimal strategies for both sexes

Time-independent optimal strategies for both sexe

Sensitivity analysis

Sensitivity analysi

Code for female forward iteration following a cohort

Code for female forward iteration following a cohor

Growth rate adjusted model - data for cohorts of 100 males and 100 females

Growth rate adjusted model - data for cohorts of 100 males and 100 female

Code to determine the average probability that a female will raise an offspring to independence

Code to determine the average probability that a female will raise an offspring to independenc

Signalling of DNA double strand breaks is done by the phosphorylation of the histone H2AX and the formation of a Damage Focus around the DSB.

<p>Phosphorylation of H2AX is caused by autophosphorylation of ATM and DNA-PKcs at the site of damage.</p

53BP1 Damage Foci induction in human MRC5 fibroblasts.

<p>Images of unstressed (A) and stressed (B) cells expressing the fusion protein AcGFP-53BP1c. Scale bar represent 10 µm. See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055190#pone.0055190.s004" target="_blank">Video S1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0055190#pone.0055190.s005" target="_blank">Video S2</a> for examples foci formation and resolution over time in unstressed and stressed MRC5 fibroblasts respectively.</p