What is the scope to test a smoking cessation intervention aimed at young people admitted to hospital?

Background: Young adults are reluctant to use evidence-based smoking cessation interventions. Subsequently, they are less successful at giving up smoking compared to older adults. This highlights the need for innovative strategies to engage young people in smoking cessation. A novel intervention using photoageing technology has been shown to be an effective trigger for smoking cessation. Aims: To conduct a pilot study deploying photoageing care technology to trigger smoking cessation attempts in young adults admitted to hospital. Method: A randomised controlled trial was designed. Thirty participants were recruited from a regional hospital in Melbourne, Australia. Participants were allocated to the intervention and control groups on alternate weeks. All participants received brief smoking cessation advice. The intervention group was digitally aged using the APRIL Face Aging Software. The primary outcomes were measured at six weeks’ post-intervention and included number of quit attempts, nicotine dependence, and progression through the stages of change model. Results: At six weeks’ post-intervention, there was no difference in quit attempts between the two groups (Mann-Whitney U=111 and p=0.484). There was also no difference in nicotine dependence (Mann-Whitney U=106 and p=0.403) or stage of change (2=1.71 and p=0.634) between the groups. Conclusion: Hospitalisation is associated with a number of barriers, which prevent the implementation of photoageing technology in this setting. Of these barriers, participant recruitment and retention pose the greatest challenge. Due to these considerations, it was not possible to demonstrate an effect size with any confidence

Academics' use of courseware materials: A survey

Learning technology has yet to enter the mainstream of higher education. The UFC-funded Teaching and Learning Technology (TLT) programme is attempting to change this by sponsoring projects concerned with courseware production and delivery. These efforts could be thwarted if the Not Invented Here syndrome prevents the use of technology-based teaching and learning materials outside the originating departments. To gain a clearer understanding of why academics have been rejecting much existing courseware, and to establish the extent of the Not Invented Here syndrome, we carried out a survey of 800 academics in eight UK universities. The survey proved to be exceptionally revealing

Hysteresis and unemployment : a preliminary investigation

This paper points out what hysteresis is using a simple model of market entry and exit. A procedure for calculating hysteresis indices for economic time series is outlined. Some preliminary results are presented to assess the explanatory power of hysteresis variables with regard to the equilibrium rate of unemployment in the UK. We find that both natural and "unnatural" variables enter a cointegrating vector for UK unemployment 1959-1996. The natural variable is the replacement ratio. The 'unnatural' variables are the hysteresis index of the exchange rate; and hysteresis indices for the real oil price and the real interest rate

Fostering communities of open educational practice: lessons from the Support Centre for Open Resources in Education

The initial flush of interest in open educational resources per se has now moved on to discussions and actions that place open educational resources (OER) within a wider set of (open) educational practices (OEP). This new focus on educational practices has encompassed the drivers and barriers to the adoption of appropriate policies and practices within higher education institutions and how best practices within one institution may help foster enhanced practices in other institutions. This paper describes the activities and outcomes of one such funded initiative to use the expertise of an early adopter of OER and OEP (The Open University) to help foster HE sector wide communities and networks of practice within England in particular but across all of the United Kingdom. This initiative was the Support Centre for Open Resources in Education (http://www8.open.ac.uk/score/), which, over a three period, has initiated a series of activities and events that have involved several hundred educational practitioners from the majority of the HEIs in England. While this single institution-led initiative has benefitted form there being a companion sector wide initiative (UKOER) led by two national organisations SCORE has succeeded in raising the profile of OER and OEP within UK HEIs by assisting existing communities of practice and by creating new communities of practice that are forming a much larger network of practice that will be sustained into the future by many of its participants. We will set out the key lessons underlying this success

Exchange Rate Uncertainty and Business Sector Investment

No abstract.

R-matrix calculations of electron impact electronic excitation of BeH

The R-matrix method is used to perform high-level calculations of electron collisions with beryllium mono-hydride at its equilibrium geometry with a particular emphasis on electron impact electronic excitation. Several target and scattering models are considered. The calculations were performed using (1) the UKRMol suite which relies on the use of Gaussian type orbitals (GTOs) to represent the continuum and (2) using the new UKRMol+ suite which allows the inclusion of B-spline type orbitals in the basis for the continuum. The final close-coupling scattering models used the UKRMol+ code and a frozen core, valence full configuration interaction, method based on a diffuse GTO atomic basis set. The calculated electronic properties of the molecule are in very good agreement with state-of-the-art electronic structure calculations. The use of the UKRMol+ suite proved critical since it allowed the use of a large R-matrix sphere (35 Bohr), necessary to contain the diffuse electronic states of the molecule. The corresponding calculations using UKRMol are not possible due to numerical problems associated with the combination of GTO-only continuum and a large R-matrix sphere. This work provides the first demonstration of the utility and numerical stability of the new UKRMol+ code. The inelastic cross sections obtained here present a significant improvement over the results of earlier studies on BeH

Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147

Epithelial cell-cell contacts maintain normal glandular tissue homeostasis, and their breakage can trigger epithelial-to-mesenchymal transition (EMT), a fundamental step in the development of metastatic cancer. Despite the ability of C-type lectin domains (CTLD) to modulate cell-cell adhesion, it is not known if they modulate epithelial adhesion in EMT and tumor progression. Here, the multi-CTLD mannose receptor, Endo180 (MRC2/uPARAP), was shown using the Kaplan-Meier analysis to be predictive of survival outcome in men with early prostate cancer. A proteomic screen of novel interaction partners with the fourth CTLD (CTLD4) in Endo180 revealed that its complex with CD147 is indispensable for the stability of three-dimensional acini formed by nontransformed prostate epithelial cells (PEC). Mechanistic study using knockdown of Endo180 or CD147, and treatment with an Endo180 mAb targeting CTLD4 (clone 39.10), or a dominant-negative GST-CTLD4 chimeric protein, induced scattering of PECs associated with internalization of Endo180 into endosomes, loss of E-cadherin (CDH1/ECAD), and unzipping of cell-cell junctions. These findings are the first to demonstrate that a CTLD acts as a suppressor and regulatory switch for EMT; thus, positing that stabilization of Endo180-CD147 complex is a viable therapeutic strategy to improve rates of prostate cancer survival

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival

Biomechanical strain imposed by age-related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the structural alterations in the basal lamina associated with age can induce mechanotransduction pathways in prostate epithelial cells (PECs) to promote invasiveness and cancer progression. To demonstrate this, we developed a 3D model of PEC acini in which thickening and stiffening of basal lamina matrix was induced by advanced glycation end-product (AGE)-dependent non-enzymatic crosslinking of its major components, collagen IV and laminin. We used this model to demonstrate that antibody targeted blockade of CTLD2, the second of eight C-type lectin-like domains in Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) that can recognize glycosylated collagens, reversed actinomyosin-based contractility [myosin-light chain-2 (MLC2) phosphorylation], loss of cell polarity, loss of cell–cell junctions, luminal infiltration and basal invasion induced by AGE-modified basal lamina matrix in PEC acini. Our in vitro results were concordant with luminal occlusion of acini in the prostate glands of adult Endo180ΔEx2–6/ΔEx2–6 mice, with constitutively exposed CTLD2 and decreased survival of men with early (non-invasive) prostate cancer with high epithelial Endo180 expression and levels of AGE. These findings indicate that AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed PECs via a molecular mechanism linked to cancer progression. This study provides a rationale for targeting CTLD2 in Endo180 in prostate cancer and other pathologies in which increased basal lamina thickness and tissue stiffness are driving factors

Bilateral Syphilitic Optic Neuropathy with Secondary Autoimmune Optic Neuropathy and Poor Visual Outcome

We describe the case of a 65-year-old man who suffered progressive visual loss despite appropriate treatment of ocular syphilis. Our patient initially presented with a unilateral 6th nerve palsy and associated double vision, which self-resolved over 6 months. His ophthalmic examination was otherwise normal. 12 months after the initial complaint, he represented with dyschromatopsia, reduced visual acuity, tonic pupils, and optic nerve atrophy. He tested positive for syphilis and was admitted for treatment of neurosyphilis with high-dose benzylpenicillin. Despite treatment, at a 4-month review his visual acuity remained poor and progression of optic nerve atrophy was noted alongside the development of bilateral central scotomas. Further testing was congruent with a diagnosis of autoimmune optic retinopathy. We propose this to be secondary to his syphilitic infection. Syphilis is known as the “great mimicker,” and despite being quite treatable, this case highlights ongoing complexity in the diagnosis and management of syphilis, unfortunately with a poor visual outcome