Mapping of loci from Solanum lycopersicoides conferring resistance or susceptibility to Botrytis cinerea in tomato

Cultivated tomato (Solanum lycopersicum, syn. Lycopersicon esculentum) is susceptible to the necrotrophic ascomycete and causal agent of gray mold, Botrytis cinerea. Resistance to this fungal pathogen is elevated in wild relatives of tomato, including Solanum lycopersicoides. An introgression line population (IL) containing chromosomal segments of S. lycopersicoides within the background of tomato cv. VF36 was used to screen the genome for foliar resistance and susceptibility to B. cinerea. Based on this screen, putative quantitative trait loci (QTL) were identified, five for resistance and two for susceptibility. Four resistance QTL decreased infection frequency while the fifth reduced lesion diameter. One susceptibility QTL increased infection frequency whereas the other increased lesion diameter. Overlapping chromosomal segments provided strong evidence for partial resistance on chromosomes 1 and 9 and for elevated susceptibility on chromosome 11. Segregation analysis confirmed the major resistance QTL on the long arm of chromosome 1 and susceptibility on chromosome 11. Linkage of partial resistance to chromosome 9 could not be confirmed. The usefulness of these data for resistance breeding and for map-based cloning of foliar resistance to B. cinerea is discussed.Peer reviewedFinal Published versio

Association of MMP-9 Quartiles with Selected Clinical Characteristics in Women.

<p>Association of MMP-9 Quartiles with Selected Clinical Characteristics in Women.</p

Plasma concentrations of inflammatory markers according to smoking status.

<p>White blood cell (WBC) count is expressed as (5×10⁹/L), C-reactive protein (CRP), MMP-9 and MMP-1 as ng/ml. logCRP and logMMP-9 were used for analyses. *: p<0.05; **: p<0.01.</p

Correlations of MMP-9 and CRP with WBC.

<p>Linear regression analysis of the correlation of WBC with MMP-9 (upper panel) and CRP (lower panel) in never (n = 243), current (n = 76) and former smokers (n = 64).</p

Association of MMP-9 Quartiles with Selected Clinical Characteristics in Men.

<p>Association of MMP-9 Quartiles with Selected Clinical Characteristics in Men.</p

Correlation between MMP-9 and WBC in apparently healthy subjects.

<p>Linear regression analysis of the correlation between MMP-9 and WBC in men (n = 383) and women (n = 356).</p

Association of WBC Quartiles with Selected Clinical Characteristics in Women.

<p>Association of WBC Quartiles with Selected Clinical Characteristics in Women.</p

Basic Clinical Characteristics and Cytokine Levels of Study Participants by Gender.

<p>Values are Mean ± SE (range).</p>*<p>: Log-transformed for analysis;</p>**<p>: Except for age, all p values are adjusted for age; Bold for p≤0.05.</p