Datamator : an authoring tool for creating datamations via data query decomposition

Datamation is designed to animate an analysis pipeline step by step, serving as an intuitive and efficient method for interpreting data analysis outcomes and facilitating easy sharing with others. However, the creation of a datamation is a difficult task that demands expertise in diverse skills. To simplify this task, we introduce Datamator, a language-oriented authoring tool developed to support datamation generation. In this system, we develop a data query analyzer that enables users to generate an initial datamation effortlessly by inputting a data question in natural language. Then, the datamation is displayed in an interactive editor that affords users the ability to both edit the analysis progression and delve into the specifics of each step undertaken. Notably, the Datamator incorporates a novel calibration network that is able to optimize the outputs of the query decomposition network using a small amount of user feedback. To demonstrate the effectiveness of Datamator, we conduct a series of evaluations including performance validation, a controlled user study, and expert interviews.NSFCNSF ShanghaiDeutsche Forschungsgemeinschaf

Design of reinforced concrete frame structure of exhibition hall

Import 23/08/2017Předmětem bakalářské práce je železobetonová dvoupatrová rámová konstrukce, která má sloužit pro občanskou vybavenost jako výstavní síň. Cílem je navrhnout a posoudit nosné prvky rámové konstrukce, konstrukce schodiště a stropů a založení na základových patkách podle metody mezních stavů, platných norem a konstrukčních zásad. Pro posouzené prvky byly vypracovány výkresy výztuže a stavební výkresy.The subject of Bachelor thesis is two storey reinforced concrete frame structure, which has to serve for civil amenitied as exhibition hall. The aim is to design and assess the support elements of frame structure, the structure of staircase and the ceilings and the foundation on foundation plinths according to the method of limit states, applicable standards and design principles. For assess elements have been created reinforcement drawings and constuction drawings.221 - Katedra konstrukcívýborn

Perioperative Toripalimab Plus Chemotherapy for Patients With Resectable Non-Small Cell Lung Cancer: The Neotorch Randomized Clinical Trial

IMPORTANCE: Adjuvant and neoadjuvant immunotherapy have improved clinical outcomes for patients with early-stage non-small cell lung cancer (NSCLC). However, the optimal combination of checkpoint inhibition with chemotherapy remains unknown. OBJECTIVE: To determine whether toripalimab in combination with platinum-based chemotherapy will improve event-free survival and major pathological response in patients with stage II or III resectable NSCLC compared with chemotherapy alone. DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial enrolled patients with stage II or III resectable NSCLC (without EGFR or ALK alterations for nonsquamous NSCLC) from March 12, 2020, to June 19, 2023, at 50 participating hospitals in China. The data cutoff date for this interim analysis was November 30, 2022. INTERVENTIONS: Patients were randomized in a 1:1 ratio to receive 240 mg of toripalimab or placebo once every 3 weeks combined with platinum-based chemotherapy for 3 cycles before surgery and 1 cycle after surgery, followed by toripalimab only (240 mg) or placebo once every 3 weeks for up to 13 cycles. MAIN OUTCOMES AND MEASURES: The primary outcomes were event-free survival (assessed by the investigators) and the major pathological response rate (assessed by blinded, independent pathological review). The secondary outcomes included the pathological complete response rate (assessed by blinded, independent pathological review) and adverse events. RESULTS: Of the 501 patients randomized, 404 had stage III NSCLC (202 in the toripalimab + chemotherapy group and 202 in the placebo + chemotherapy group) and 97 had stage II NSCLC and were excluded from this interim analysis. The median age was 62 years (IQR, 56-65 years), 92% of patients were male, and the median follow-up was 18.3 months (IQR, 12.7-22.5 months). For the primary outcome of event-free survival, the median length was not estimable (95% CI, 24.4 months-not estimable) in the toripalimab group compared with 15.1 months (95% CI, 10.6-21.9 months) in the placebo group (hazard ratio, 0.40 [95% CI, 0.28-0.57], P \u3c .001). The major pathological response rate (another primary outcome) was 48.5% (95% CI, 41.4%-55.6%) in the toripalimab group compared with 8.4% (95% CI, 5.0%-13.1%) in the placebo group (between-group difference, 40.2% [95% CI, 32.2%-48.1%], P \u3c .001). The pathological complete response rate (secondary outcome) was 24.8% (95% CI, 19.0%-31.3%) in the toripalimab group compared with 1.0% (95% CI, 0.1%-3.5%) in the placebo group (between-group difference, 23.7% [95% CI, 17.6%-29.8%]). The incidence of immune-related adverse events occurred more frequently in the toripalimab group. No unexpected treatment-related toxic effects were identified. The incidence of grade 3 or higher adverse events, fatal adverse events, and adverse events leading to discontinuation of treatment were comparable between the groups. CONCLUSIONS AND RELEVANCE: The addition of toripalimab to perioperative chemotherapy led to a significant improvement in event-free survival for patients with resectable stage III NSCLC and this treatment strategy had a manageable safety profile. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04158440

Formation of nanocrystalline tungsten by selective laser melting of tungsten powder

Nanocrystalline tungsten was obtained by selective laser melting (SLM) in the present work. The microstructures and compositions revealed that the nanocrystalline tungsten could be fabricated via the SLM method using pure tungsten powder. It was found that the produced nanocrystalline tungsten microstructure could be regarded as a resultant of solid forces by laser, which grow along a special crystal surface. The metallurgical mechanisms for the formation of such a novel structure through SLM process were also addressed

Ultrasound‐trigged micro/nanorobots for biomedical applications

Abstract Micro‐ and nanorobots (MNRs) propelled by external actuations have broad potential in biomedical applications. Among the numerous external excitations, ultrasound (US) features outstanding practical significance with merits of its noninvasiveness, tunability, penetrability, and biocompatibility. Attributing to various physiochemical effects of US, it can propel the MNRs with sophisticated structures through asymmetric acoustic streaming, bubble oscillation, and so on. In this review, we introduce several advanced and representative US‐propelled MNRs with inhomogeneous density distribution, asymmetric shape, hollow cavity, etc. The potential biomedical applications of these cutting‐edge MNRs are also presented, including intracellular delivery, harmful substances collection, and so on. Furthermore, we conclude the advantages and limitations of US‐propelled MNRs and prospect their future developments in multidisciplinary fields

Microstructural evolvement and formation of selective laser melting W–Ni–Cu composite powder

W–Ni–Cu alloy (90 wt% W, 7.5 wt% Ni, and 2.5 wt% Cu) parts were successfully fabricated via selective laser melting method. Phases, microstructure, compositions, and laser forming parameters of laser melted samples were investigated. It was found that the W–Ni–Cu powder system was based on the mechanism of liquid solidification. This process was realized through full melting of W, Ni, and Cu particles under high laser energy input. However, using relatively lower energy input, particle bonding was realized through liquid phase sintering with complete melting of Ni–Cu acting as binder and nonmelting of W acting as structure. Due to the Ni–Cu solid solution phase that appeared in a wide range from 1,084 to 1,455 °C, a coherent matrix interface can be observed after solidification. The microhardness of laser-fabricated specimens varied with different powder layer thicknesses, resulting from the laser-treated condition and ability of trapped air in the loose powder bed to escape. The metallurgical mechanisms were also addressed

Comparison of metabolic rates of ropivacaine in cerebrospinal fluid as inferred from plasma concentrations between elderly patients and young patients

Abstract Background With the aging of human society, more and more elderly patients have to undergo surgery and anesthesia. Clinical observations have indicated from time to time that spinal anesthesia in the elderly appears to last longer than in young people, although there is limited research in this area and the mechanism is unclear at present time. This research work is expected to help understand the decline of local anesthetic metabolism in cerebrospinal fluid of elderly patients so as to help them with precise anesthesia and rapid rehabilitation. Methods Twenty patients with spinal anesthesia in orthopedic lower limb surgery were selected to study the rate of drug metabolism in cerebrospinal fluid in two age groups, i.e.,18–30 years old and 75–90 years old. Ropivacaine in peripheral blood is used as a probe to reflect the speed of drug metabolism in cerebrospinal fluid. The contents of total Aβ protein and hyaluronic acid in the cerebrospinal fluid were investigated as well. Results The equivalent dose of ropivacaine anesthetizes the elderly group for a longer time. The metabolism rate of ropivacaine in an elderly patient was slower than that of a young patient. No significant difference in total Aβ protein between the two groups was observed while hyaluronic acid in the elderly group was significantly higher than that in the young group. Conclusions This study shows that the dose of ropivacaine should be reduced when used for anesthesia in elderly patients. The cumulation of ropivacaine and HA appears to imitate the degeneration of central lymphatic circulation metabolism in elderly people

Health literacy in patients with gout: A latent profile analysis.

ObjectivesUnderstanding the health literacy status of patients with gout diagnosis is essential for improving the health of this population. Our study aimed to investigate the latent profiles of health literacy in patients with gout and to analyze differences in characteristics across potential profiles.MethodsThis was a cross-sectional study. Eligible participants attended the Shandong Gout Medical Center, from March 2023 to May 2023 and self-reported gout diagnosis. We used the Health Literacy Scale for Patients with Gout designed and validated by our team. The scale had good reliability and validity among patients with gout. 243 patients completed the Demographic Information Questionnaire and the Health Literacy Scale for Patients with Gout. We used latent profile analysis to identify the latent profiles of gout patients' health literacy. We used Chi-square tests with Bonferroni correction to analyze differences in demographics and illness characteristics across identified profiles.ResultsThree profiles of patients with gout emerged (prevalence): the low literacy-low critical group (21.81%), the moderate literacy group (42.79%), and the high literacy-stable group (35.39%). The three groups differed in age, education level, monthly income, disease duration, and place of residence (PConclusionsThe health literacy of patients with gout was heterogeneous. Healthcare professionals should adopt targeted interventions based on the characteristics of each latent health literacy profile to improve the health literacy level of patients with gout

Datamator: An Authoring Tool for Creating Datamations via Data Query Decomposition

Funding Information: This research was funded by NSFC 62061136003, NSFC 62002267, NSF Shanghai 23ZR1464700, NSFC 62072338, and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 449742818. Publisher Copyright: © 2023 by the authors.Datamation is designed to animate an analysis pipeline step by step, serving as an intuitive and efficient method for interpreting data analysis outcomes and facilitating easy sharing with others. However, the creation of a datamation is a difficult task that demands expertise in diverse skills. To simplify this task, we introduce Datamator, a language-oriented authoring tool developed to support datamation generation. In this system, we develop a data query analyzer that enables users to generate an initial datamation effortlessly by inputting a data question in natural language. Then, the datamation is displayed in an interactive editor that affords users the ability to both edit the analysis progression and delve into the specifics of each step undertaken. Notably, the Datamator incorporates a novel calibration network that is able to optimize the outputs of the query decomposition network using a small amount of user feedback. To demonstrate the effectiveness of Datamator, we conduct a series of evaluations including performance validation, a controlled user study, and expert interviews.Peer reviewe