Looking at Large Law Firms: Any Role Left for the Law Schools?

The Growth of Large Law Firms and Its Effect on the Legal Profession and Legal Education, Symposiu

Mortality in patients with successful initial response to highly active antiretroviral therapy is still higher than in non-HIV-infected individuals.

Mortality in HIV-infected patients has decreased dramatically since the introduction of highly active antiretroviral therapy (HAART). We analyzed progression to death in a population of 3678 antiretroviral treatment-naive patients from the ATHENA national observational cohort from 24 weeks after the start of HAART. Mortality was compared with that in the general population in the Netherlands matched by age and gender. Only log-transformed CD4 cell count (hazard ratio [HR] = 0.50, 95% confidence interval [CI]: 0.40 to 0.61 per unit increase) and plasma viral load (HR = 0.30, 95% CI: 0.15 to 0.60, HIV RNA level or = 100,000 copies/mL) measured at 24 weeks and infection via intravenous drug use (IDU) (HR = 0.16, 95% CI: 0.10 to 0.26, non-IDU vs. IDU) were significantly associated with progression to death. For non-IDU patients with 600 x 10 CD4 cells/L and an HIV RNA level <100,000 copies/mL at 24 weeks, mortality was predicted to be 5.3 (95% CI: 3.5 to 8.4) and 10.4 (95% CI: 6.4 to 17.4) times higher than in the general population for 25-year-old men and women, respectively, and 1.15 (95% CI: 1.08 to 1.25) and 1.29 (95% CI: 1.16 to 1.50) times higher for 65-year-old men and women, respectively. Hence, mortality in HIV-infected patients with a good initial response to HAART is still higher than in the general population

Broadband spin-controlled focusing via logarithmic-spiral nanoslits of varying width

This work presents analytical, numerical and experimental demonstrations of light diffracted through a logarithmic spiral (LS) nanoslit, which forms a type of switchable and focus-tunable structure. Owing to a strong dependence on the incident photon spin, the proposed LS-nanoslit converges incoming light of opposite handedness (to that of the LS-nanoslit) into a confined subwavelength spot, while it shapes light with similar chirality into a donut-like intensity profile. Benefitting from the varying width of the LS-nanoslit, different incident wavelengths interfere constructively at different positions, i.e., the focal length shifts from 7.5 μm (at λ = 632.8 nm) to 10 μm (at λ = 488 nm), which opens up new opportunities for tuning and spatially separating broadband light at the micrometer scale

Identification and characterization of microsatellite loci in two socially complex old world tropical babblers (Family Timaliidae)

Background: Although the highest diversity of birds occurs in tropical regions, little is known about the genetic mating systems of most tropical species. We describe microsatellite markers isolated in the chestnut-crested yuhina (Staphida everetti), endemic to the island of Borneo, and the grey-throated babbler (Stachyris nigriceps), widely distributed across Southeast Asia. Both species belong to the avian family Timaliidae and are highly social, putatively cooperatively breeding birds in which helpers attend the nests of members of their social group. We obtained DNA from individuals in social groups breeding in Kinabalu Park, Malaysian Borneo. Results: We used a shotgun sequencing approach and 454-technology to identify 36 microsatellite loci in the yuhina and 40 in the babbler. We tested 13 primer pairs in yuhinas and 20 in babblers and characterized eight polymorphic loci in 20 unrelated female yuhinas and 21 unrelated female babblers. Polymorphism at the yuhina loci ranged from 3 to 9 alleles, observed heterozygosities from 0.58 to 1.00, and expected heterozygosities from 0.64 to 0.81. Polymorphism at the babbler loci ranged from 3 to 12 alleles, observed heterozygosities from 0.14 to 0.90 and expected heterozygosities from 0.14 to 0.87. One locus in the yuhina deviated significantly from Hardy–Weinberg equilibrium. We detected nonrandom allele associations between two pairs of microsatellite loci in each species. Conclusions: Microsatellite markers will be used to describe the genetic mating system of these socially complex species and to measure genetic parentage and relatedness within social groups

Time-of-flight imaging of invisibility cloaks

As invisibility cloaking has recently become experimental reality, it is interesting to explore ways to reveal remaining imperfections. In essence, the idea of most invisibility cloaks is to recover the optical path lengths without an object (to be made invisible) by a suitable arrangement around that object. Optical path length is proportional to the time of flight of a light ray or to the optical phase accumulated by a light wave. Thus, time-of-flight images provide a direct and intuitive tool for probing imperfections. Indeed, recent phase-sensitive experiments on the carpet cloak have already made early steps in this direction. In the macroscopic world, time-of-flight images could be measured directly by light detection and ranging (LIDAR). Here, we show calculated time-of-flight images of the conformal Gaussian carpet cloak, the conformal grating cloak, the cylindrical free-space cloak, and of the invisible sphere. All results are obtained by using a ray-velocity equation of motion derived from Fermat's principle.Comment: 11 pages, 6 figures, journal pape

City Energy Demand Simulation (CEDS) Feasibility Study

CEDS - The City Energy Demand Simulation - provides cities and local authorities with the means to visualise future energy demand (including gas and electricity) for any geographic area ranging from a street, to a district, to the city itself, including both residential and industrial/commercial energy demand.CEDS allows planners and decision makers to easily visualise the impacts of alternative demand and supply side energy investment strategies on overall energy costs, emissions, and fuel poverty levels. This will be important for cities and planners because the innovative features of CEDS will enable planners to understand the impacts of new energy technology deployments on the energy demand of buildings. - CEDS can demonstrate the relative economic and environmental attractiveness of local energy supply schemes such as district heating combined with power versus importing electricity from the grid; - CEDS can illuminate the impacts of technology deployment by social geography within the city boundaries Therefore, CEDS will allow cities and local authorities to clearly identify how to deploy limited capital budgets to greatest effect when developing low carbon, cost effective local energy infrastructure. By modelling future demand, supply and cost scenarios, cities will be able to prioritise the development of local energy assets, such as district heating networks, energy from waste, retrofit and new build locations. CEDS will enable cities to understand how they can deliver on their priorities for ensuring there are cost effective locations for business and industry, with a secure supply, whilst also helping tackle fuel poverty and reducing carbon emissions and energy costs

Photonic Crystal Vertical Cavity Lasers

Photonic crystal confinement in vertical cavity surface-emitting lasers (VCSELs) is a robust and reliable technology for achieving operation in the fundamental lateral mode and is potentially applicable to a variety of materials systems and operating wavelengths. We demonstrate photonic crystal VCSELs operating in a single transverse mode with over 30 dB side mode suppression and over 1 mW of output power. These lasers have been subjected to a post-process technique to introduce the etched holes making up the photonic crystals that surround a centralized defect in which lasing occurs. We also show that coupling between adjacent defects in a photonic lattice is possible, further increasing the power available in the devices