An investigation into emotional engagement of holography for museum display

This study delves into the emotional engagement elicited by displaying holograms in museum settings, offering a comprehensive analysis of visitors’ emotional responses and the technological features that influence them. Utilising a qualitative approach complemented by a TF-IDF analysis, the research gathered data from diverse participants who experienced holographic exhibits. The study revealed a range of emotional responses, with ‘Curiosity’ and ‘Amazement’ being predominant, signifying the ability of the display of holograms to enhance visitor engagement and learning experiences significantly. Key technological aspects of holography, such as display method, colour, and three-dimensionality, were crucial in eliciting strong emotional responses and deepening understanding of the exhibit content. The study also highlighted the long-term impact of these experiences, suggesting that the display of holograms can leave a lasting impression and foster sustained interest in museum visits. This study enriches the field of museology by shedding light on the emotional dimensions of visitor interactions with holographic technology. The findings reveal the significant potential of holography to deepen visitor engagement, suggesting that, when effectively implemented, the display of holograms can significantly elevate the museum experience. This research highlights the importance of understanding and catering to visitors’ emotional and experiential needs in the evolving landscape of museum exhibit design

Association of LMP/TAP Gene Polymorphisms with Tuberculosis Susceptibility in Li Population in China

Background: Tuberculosis (TB) is a contagious disease affected by multiple genetic and environmental factors. Several association studies have suggested that cellular immune response is vital for controlling and preventing of tuberculosis infection. Low molecular weight polypeptides (LMPs) and transporters with antigen processing (TAPs) are the main molecules in the processing and presentation pathway for intracellular antigens. This study was performed to elucidate whether these antigen-processing genes (LMP/TAP) polymorphisms could be associated with the risk of tuberculosis infection in China. Methodology/Principal Findings: We recruited 205 active pulmonary tuberculosis patients and 217 normal controls from Li population for this study. Four polymorphisms of LMP/TAP genes were determined by PCR-RFLP assay and haplotypes were constructed by software PHASE 1.0. Of the total four polymorphisms, genotype frequencies of LMP7 AA homozygote and CA heterozygote were significantly greater among cases compared to controls, with odds ratio of 3.77 (95 % CI: 1.60–8.89; P = 0.002) and 2.97 (95 % CI: 1.80–4.90; P,0.0001), respectively. The genotypes of TAP1-2 GG homozygote and AG heterozygote were more frequent in subjects with TB than in controls, with odds ratio of 3.94 (95 % CI: 1.82–8.53; P = 0.001) and 2.87 (95 % CI: 1.75–4.71; P,0.0001), respectively. Similarly, we found that haplotype B which carried LMP7 and TAP1-2 variations significantly increased the susceptibility to TB (OR = 3.674, 95 % CI: 2.254–5.988; P,0.0001). Moreover, it i

Role of co-factor Strap in the stress response

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Associations of serum follicle-stimulating hormone and luteinizing hormone levels with fat and lean mass during menopausal transition

Introduction The association of serum follicle-stimulating hormone (FSH) level with body fat mass remains inconclusive. Furthermore, little was known on the association of luteinizing hormone (LH) with body fat. This study aimed to investigate the associations of serum FSH and LH levels with fat and lean mass in women during menopausal transition. Methods The data analyzed in this study were derived from the National Health and Nutrition Examination Survey from 1999 to 2002. Women aged from 35 to 60 years were eligible. Serum FSH and LH levels were assayed using the Microparticle Enzyme Immunoassay technology. A dual energy X-ray absorptiometry was used to measure body fat mass and lean mass. Fat mass index (FMI) and fat-free mass index (FFMI) were respectively used to assess fat and lean mass. General linear regression was employed to examine the associations of serum FSH and LH levels with FMI and FFMI. Results This study included 1329 women. For the total participants, elevated serum FSH and LH levels were associated with increased FMI (β= 0.004 and 0.007; 95% CI: 0.002, 0.006 and 0.004, 0.010, respectively) and a decreased FFMI (β= -0.004 and -0.007; 95% CI: -0.006, -0.002 and -0.010, -0.004, respectively). Furthermore, the significant associations of serum FSH and LH levels with FMI and FFMI were fully observed in postmenopausal women, especially in a certain range of higher serum FSH and LH quartiles. Conclusion Elevated serum FSH and LH levels were associated with increased body fat mass but a decreased lean mass in postmenopausal women but not in premenopausal women. Furthermore, only higher serum FSH and LH percentiles were associated with fat and lean mass in postmenopausal women

An investigation into emotional engagement of holography for museum display

This study delves into the emotional engagement elicited by displaying holograms in museum settings, offering a comprehensive analysis of visitors’ emotional responses and the technological features that influence them. Utilising a qualitative approach complemented by a TF-IDF analysis, the research gathered data from diverse participants who experienced holographic exhibits. The study revealed a range of emotional responses, with ‘Curiosity’ and ‘Amazement’ being predominant, signifying the ability of the display of holograms to enhance visitor engagement and learning experiences significantly. Key technological aspects of holography, such as display method, colour, and three-dimensionality, were crucial in eliciting strong emotional responses and deepening understanding of the exhibit content. The study also highlighted the long-term impact of these experiences, suggesting that the display of holograms can leave a lasting impression and foster sustained interest in museum visits. This study enriches the field of museology by shedding light on the emotional dimensions of visitor interactions with holographic technology. The findings reveal the significant potential of holography to deepen visitor engagement, suggesting that, when effectively implemented, the display of holograms can significantly elevate the museum experience. This research highlights the importance of understanding and catering to visitors’ emotional and experiential needs in the evolving landscape of museum exhibit design

Analysis of PM2.5 collection efficiency in a wire-cylinder ESP with ionic wind effect under multi-field coupling

In order to investigate the PM2.5 collection efficiency of a wire-cylinder electrostatic precipitator (ESP) under the action of ionic wind, PM2.5 removal mechanism was studied, and an ESP mathematic model including the multi-field coupling between gas flow field, electric field and particle dynamical field was built. By applying Deutsch-Anderson Equation to process and analyze the numerical solution after compiling user-defined function (UDF) program and linking it to Fluent, grade collection efficiency and overall collection efficiency for PM2.5 were obtained. Numerical results indicate that PM2.5 removal performance under the consideration of ionic wind is better, and the contribution of ionic wind to PM2.5 removal performance is different by changing operating voltage and gas velocity. The research results can provide references for researchers to design a novel wire-cylinder ESP

Novel MMP-9 Substrates in Cancer Cells Revealed by a Label-free Quantitative Proteomics Approach*S⃞

Matrix metalloproteinase-9 (MMP-9) is implicated in tumor metastasis as well as a variety of inflammatory and pathological processes. Although many substrates for MMP-9, including components of the extracellular matrix, soluble mediators such as chemokines, and cell surface molecules have been identified, we undertook a more comprehensive proteomics-based approach to identify new substrates to further understand how MMP-9 might contribute to tumor metastasis. Previous proteomics approaches to identify protease substrates have depended upon differential labeling of each sample. Instead we used a label-free quantitative proteomics approach based on ultraperformance LC-ESI-high/low collision energy MS. Conditioned medium from a human metastatic prostate cancer cell line, PC-3ML, in which MMP-9 had been down-regulated by RNA interference was compared with that from the parental cells. From more than 200 proteins identified, 69 showed significant alteration in levels after depletion of the protease (>±2-fold), suggesting that they might be candidate substrates. Levels of six of these (amyloid-β precursor protein, collagen VI, leukemia inhibitory factor, neuropilin-1, prostate cancer cell-derived growth factor (PCDGF), and protease nexin-1 (PN-1)) were tested in the conditioned media by immunoblotting. There was a strong correlation between results by ultraperformance LC-ESI-high/low collision energy MS and by immunoblotting giving credence to the label-free approach. Further information about MMP-9 cleavage was obtained by comparison of the peptide coverage of collagen VI in the presence and absence of MMP-9 showing increased sensitivity of the C- and N-terminal globular regions over the helical regions. Susceptibility of PN-1 and leukemia inhibitory factor to MMP-9 degradation was confirmed by in vitro incubation of the recombinant proteins with recombinant MMP-9. The MMP-9 cleavage sites in PN-1 were sequenced. This study provides a new label-free method for degradomics cell-based screening leading to the identification of a series of proteins whose levels are affected by MMP-9, some of which are clearly direct substrates for MMP-9 and become candidates for involvement in metastasis