In vitro susceptibility of 120 strains of Neisseria gonorrhoeae isolated in Kyrghyzstan.

BACKGROUND: The World Health Organization has established a worldwide program for gonococcal antimicrobial surveillance, but so far no data on gonococcal susceptibility in Central Asia are available. GOAL: The need for biological data on the susceptibility of Neisseria gonorrhoeae in Kyrghyzstan, to enable adaptation of the national treatment protocol for gonococcal infections, led Médecins Sans Frontières and Epicentre to conduct a survey in collaboration with the Alfred Fournier Institute in Paris and the health authorities in Bishkek. STUDY DESIGN: In vitro susceptibility of N gonorrhoeae strains was determined with use of the reference agar-plate dilution technique. RESULTS: Results for 11 antibiotics tested on 120 strains of gonococci showed a low proportion (11.7%) of penicillinase-producing N gonorrhoeae and high proportions of intermediate or resistant strains to the majority of the antibiotics tested, including fluoroquinolones (>or=25% of strains resistant). All the strains were susceptible to spectinomycin, and only two strains had decreased susceptibility to cefixime. CONCLUSION: The therapeutic choices available in Kyrghyzstan appear to be limited to cephalosporins and spectinomycin

Metabolic cardioprotection: new concepts in implementation of cardioprotective effects of meldonium

Recent studies confirm the need to find means to correct ischemic / reperfusion injury due to the hemodynamic medicine, which are already known do not have the proper cardioprotective effects. Key issue is the possibility of drug effects on the mitochondria of cardiomyocytes that controls the aerobic metabolism and maintenance of ATP admission into cardiomyocyte

Social and psychological features of inter-cultural adaptation of Russian students in different universities

Modern globalisation processes, the rapid entry of Russia into the world community, have given more opportunities to interact with various ethnic groups ranging from short-term tourist and business contacts to complex processes of migration and emigration. Migrants and visitors have different goals for staying in a new country, meanwhile the researchers note a lot in common within the adaptation processes of both groups. In particular, tension, stresses and experience of cultural shock during adaptation are observed. Therefore, it is necessary to conduct psychological studies not only of migrants who come for a long time to a new country, but also of visitors, i.e., interns, students who come to study in foreign universitie

Critical analysis of factors determining sustainable development of territories in a strategic perspective

The main interpretations of terms, development trends, foreign and domestic experience within the concept of sustainable development of territories have been considered. The importance of cooperative interaction and cooperation between actors in the same area in the context of existing constraints, barriers and opportunities for the deployment of the processes under consideration, has been confirmed. A statistical comparative analysis of the dynamics of changing trends in the interaction between research organisations and industrial enterprises of the regions has been carried out in comparison with Russian and global trends. The interrelationships between the key factors relating to financial support processes, infrastructure capacity and the research and education component have been revealed and their impact on territorial development has been highlighted. Scientific research methods such as analysis and generalization and correlation analysis were used within the framework of the article

Experimental approaches to the assessment of potential cardioprotective means with doxorubicin-associated cardiomyopathy

Development of methodological approaches for evaluation of cardioprotective activity of drugs in doxorubicin cardiomyopath

Pharmacological correction of L-NAME-induced oxide deficiency with derivatives of 3-(2,2,2-trimethylhydrazinium) propionate

This paper deals with the study of correction of L-NAME-induced endothelial dysfunction by means of 3-(2,2,2-trimethylhydrazinium) propionate derivative

Evaluation of grain yield and quality in maize hybrids of various origin under the conditions of Primorsky Territory

Background. This study was dedicated to the evaluation and selection of maize hybrids of different origin for important agronomic traits and for protein and oil accumulation in grain under the conditions of Primorsky Territory, as well as for their possible use as source material for breeding.Materials and methods. Twenty-two grain maize hybrids of various geographic origin were studied at the Federal Scientific Center of Agricultural Biotechnology of the Far East named after A.K. Chaika” in 2017–2020. Useful agronomic characters and biochemical indications were assessed, correlations between parameters were established, and an integrated evaluation of maize hybrids was made. The hybrids were ranked relative to a predetermined ideal model.Results. Based on the results of the integrated assessment, maize hybrids Р 7709, Р 8688 and Р 8523 (Pioneer Corporation) and Si Rotango (Syngenta) had the highest scores for a set of important agronomic traits under the conditions of Primorsky Territory. Higher protein content levels were detected in maize grain when the combination of temperature and moisture was optimal (Selyaninov’s hydrothermal coefficient = 1.1). The highest oil content was observed at an enhanced level of soil moisture (HTC = 3.1). The Si Rotango hybrid had the maximum protein content. The NUR, Ladozhsky 181 MV and P 7054 hybrids showed the maximum in oil content. Strong direct correlations were discovered between the yield and the weight of 1000 kernels and one ear, and between grain yield and the height of the lower ear position. Weak reverse correlations were observed between biochemical parameters and yield, and between a FAO maturity group and grain yield

The East and gender in popular culture: the visual discourse of the harem in the modern television series

The article is devoted to the study of the peculiarities of gender marking of the artistic space of television series in the context of postcolonial theory and feminist criticism. By the material of artistic images of the harem cultural, national and gender features of representation of the East in modern mass cinema are studie

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis.

ObjectiveEtrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are implicated in leucocyte migration and retention in ulcerative colitis (UC). This randomised phase I study evaluated the safety and pharmacology of etrolizumab in patients with moderate to severe UC.DesignIn the single ascending dose (SAD) stage, etrolizumab (0.3, 1.0, 3.0, 10 mg/kg intravenous, 3.0 mg/kg subcutaneous (SC) or placebo) was administered 4:1 (n=25) in each cohort. In the multiple dose (MD) stage, new patients received monthly etrolizumab (0.5 mg/kg SC (n=4), 1.5 mg/kg SC (n=5), 3.0 mg/kg SC (n=4), 4.0 mg/kg intravenous (n=5)) or placebo (n=5). The pharmacokinetics was studied and Mayo Clinic Score evaluated at baseline, day 29 (SAD), and days 43 and 71 (MD).ResultsIn the SAD stage, there were no dose limiting toxicities, infusion or injection site reactions. Two impaired wound healing serious adverse events occurred in two patients receiving etrolizumab. In the MD stage, there were no dose limiting toxicities, and no infusion or injection site reactions. Headache was the most common adverse event, occurring more often in etrolizumab patients. Antietrolizumab antibodies were detected in two subjects. The duration of β7 receptor full occupancy was dose related. A clinical response was observed in 12/18 patients, and clinical remission in 3/18 patients treated with etrolizumab in the MD stage, compared with 4/5 and 1/5 placebo patients, respectively.ConclusionEtrolizumab is well tolerated in moderate to severe UC. Further investigation is warranted

Preparation de formamide de la benzophenone oxime et les O-derives

Бензгидрилмочевины являются биологически активными соединениями, проявляющими выраженную противосудорожную активность, а субстраты в синтезе бензгидрилмочевин -бензгидриламины. Поэтому целью нашей работы была разработка удобного и экономически выгодного способа получения бензгидриламинов.Первым этапом работы было получение оксимабензофенона, который в дальнейшем восстанавливался до бензгидриламина. Таким образом,нами был найден эффективный метод восстановления оксимабензофенона и его О-производных до соответствующего формамида., который, как известно при гидролизе образует бензгидриламин