Ansia di separazione nell'adulto e lutto complicato

Introduzione: Negli ultimi anni, il lutto complicato (LC) ha attratto sempre di più l'attenzione dei ricercatori di tutto il mondo per la sua dimostrata importanza psicopatologica. Tuttavia, le reciproche relazioni intercorrenti tra LC ed ansia di separazione nell'adulto (SEPAD) non sono ancora chiare. Obiettivo del presente studio è quello di valutare la prevalenza e la significatività clinica della SEPAD in un campione di soggetti affetti da LC che hanno ricercato aiuto presso la nostra struttura. Metodo: 151 adulti con LC, arruolati in uno studio randomizzato-controllato che comparava l'effetto della "Complicated Grief Treatment" a quella dell'"Interpersonal Psychotherapy", sono stati valutati tramite l'Inventory of Complicated Grief (ICG), l'Intervista Clinica Strutturata per il DSM-IV, la Hamilton Rating Scale for Depression (HAM-D), la Work and Social Adjustment Scale (WSAS), la Separation Anxiety Symptoms Questionnaire (ASA-27), il Grief Related Avoidance Questionnaire (GRAQ), il Peritraumatic Dissociative Experiences Questionnaire (PDEQ) e l'Impact of Events Scale (IES). Risultati: 63 individui con LC sono risultati affetti da SEPAD (punteggio all'ASA-27 ≥ 22). Gli individui con SEPAD hanno riportato più frequentemente la perdita di un altro parente o di un amico (p=.05), più alti punteggi alla ICG (p=.002), intrusione (p=.004) e evitamento (p=<.001) alla IES, HAM-D (p<.001) and WSAS (p=.04). Il punteggio totale all'ASA-27 è risultato correlato ai punteggi della ICG (p<.0001) e ai punteggi delle sottoscale IES intrusione (p<.0001) ed evitamento (p<.0001). I soggetti con SEPAD hanno mostrato tassi di prevalenza lifetime significativamente più alti di disturbo di panico (PD) (p=.001) e disturbo bipolare (p=.02), mentre tassi maggiori, sebbene non statisticamente significativi, di disturbo da stress post-traumatico (PTSD). Conclusioni: La SEPAD ha un'elevata prevalenza negli individui con LC ed è associata ad una maggiore severità sintomatologica con più alti tassi di comorbidità con PTSD and PD

The mediating effect of mood spectrum on the relationship between autistic traits and catatonia spectrum

BackgroundIn the recent years, several studies have shown a correlation between autism spectrum disorder (ASD) and catatonia. It is also known that both conditions are found to be associated with mood disorders. This study aimed to investigate the relationship between autistic traits and catatonic symptoms, as well as the potential mediating role of mood disorder spectrum in the relationship between them.MethodsThe total sample of 514 subjects was composed by four diagnostic groups, composed by patients affected by catatonia (CTN), borderline personality disorder (BPD), major depressive disorder (MDD) and healthy controls (HC). Subjects were assessed with the SCID-5-RV, the Adult Autism Subthreshold Spectrum (AdAS Spectrum) and the Catatonia Spectrum (CS) and the Mood Spectrum Self-Report (MOODS-SR). Statistical analyses included Pearson’s coefficient calculation, multiple linear regression, and mediation analysis.Resultsall the correlations appear to be strongly positive and significant with the strongest coefficient emerging between AdAS Spectrum total score and CS total score (r = 0.762, p &lt; 0.001). The Mediation Analysis showed that AdAS Spectrum total score showed a significant indirect effect on CS total score through MOODS-SR total score (b = 0.168, 95% bootstrapped CI [0.127:0.207]).ConclusionThe present study highlights the presence of a mediating role of the mood disorder spectrum in the relationship between autistic traits and the catatonia spectrum

Orthorexia and autism spectrum in University workers: relationship with gender, body mass index and dietary habits

To date, few studies have investigated the relationship between autistic traits and emerging phenotypes of restrictive disorders, such as Orthorexia nervosa (ON). The aim of the present work was to investigate the relationship between ON symptoms and autistic traits in a population of University employees, focusing on the impact of gender, weight and type of diet

Investigating Orthorexia Nervosa With the ORTO-R in a Sample of University Students With or Without Subthreshold Autism Spectrum: Focus on Dietary Habits and Gender Differences

The aim of the present study was to investigate the presence of Orthorexia (ON) symptoms in a sample of University students with or without autistic traits (AT), specifically focusing on evaluating the role of gender and of dietary habits in the association between ON and autism spectrum

Implications of Social Anxiety Symptoms in Adults with Autism Spectrum Disorder: Is There a Predictive Role of Interpersonal Sensitivity and Substance Abuse?

Social anxiety disorder (SAD) has been frequently reported by subjects with Autism Spectrum Disorder (ASD). However, interestingly, the overlap between social anxiety and autistic traits may sometimes impede ASD diagnosis in subjects without intellectual or language impairment. The aim of the present work was to evaluate the presence and correlates of social phobic features among subjects with ASD, with a specific focus on evaluating which social anxiety symptoms may be statistically predictive of an ASD diagnosis. With this purpose, 48 subjects with ASD and 48 gender- and age- matched healthy controls (HCs) were recruited and assessed with the SHY-SV and the AdAS Spectrum questionnaires. Results highlighted higher scores in all SHY-SV Spectrum domains and total scores for the ASD group. Moreover, AdAS Spectrum scores were significantly correlated with all SHY-SV domain and total scores. A logistic regression analysis highlighted the SHY-SV Interpersonal sensitivity and Substance Abuse domains scores as significant positive predictors of an ASD diagnosis. These results confirm the link between ASD and SAD. Because of this association, particular attention should be paid to subjects with high interpersonal sensitivity traits and substance abuse problems

Dengue-4 false negative results by Panbio (R) Dengue Early ELISA assay in Brazil

Background: Dengue is a serious public health problem in numerous countries. the ability to rapidly diagnosis dengue is important for patient triage and management. Detection of dengue viral protein, NS1, represents a new approach to dengue diagnosis.Objective: the present study aims to evaluate if there are false negative results using the NS1 Ag rapid assay (Panbio (R) Dengue Early ELISA) in two different epidemiological situations (epidemic and non-epidemic).Study design: 220 serum samples from patients with clinical symptoms of classical dengue fever were tested by NS1 antigen capture ELISA and Multiplex-Nested-PCR.Results: in samples collected in a non-epidemic period we found a 100% agreement of ELISA and RTPCR in dengue negative samples and 85% agreement of ELISA and RT-PCR in dengue positive samples. But when we tested samples during an epidemic period (large DENV-4 outbreak) we found 15% false negative results (p<0.05) in dengue negative samples.Conclusions: Due to false negative results for DENV-4, the sole use of the Panbio Dengue Early ELISA assay as a screening method for monitoring circulating dengue serotypes must be reevaluated. (C) 2013 Elsevier B.V. All rights reserved.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fac Med Sao Jose do Rio Preto FAMERP, BR-15090000 Sao Jose Do Rio Preto, SP, BrazilUniv Estadual Paulista Julio de Mesquitta & Filho, Sao Jose Do Rio Preto, SP, BrazilUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilPrefeitura Sao Jose do Rio Preto, Dept Vigilancia Saude, Sao Jose Do Rio Preto, SP, BrazilUniv Fed Mato Grosso, Sinop, Mato Grosso, BrazilTufts Univ, Cummings Sch Vet Med, Dept Infect Dis & Global Hlth, North Grafton, MA USAUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilFAPESP: 2012/11733-6FAPESP: 2011/10458-9Web of Scienc