UHECR narrow clustering correlating IceCube through-going muons

The recent UHECR events by AUGER and the Telescope Array (TA) suggested that wide clusterings as the North and South, named Hot Spot, are related to near AGNs such as the one in M82 and Cen A. In the same frame since 2008 we assumed that the UHECR are made by light and lightest nuclei to explain the otherwise embarrassing absence of the huge nearby Virgo cluster, absence due to the fragility and the opacity of lightest nuclei by photo-dissociation from Virgo distances. Moreover UHECR map exhibits a few narrow clustering, some near the galactic plane, as toward SS 433 and on the opposite side of the plane at celestial horizons: we tagged them in 2014 suggesting possible near source active also as a UHE neutrino. Indeed since last year, 2015, highest IceCube trough-going muons, UHE up-going neutrino events at hundreds TeV energy, did show (by two cases over three tagged in North sky) the expected overlapping of UHE neutrinos signals with narrow crowding UHECR. New data with higher energy threshold somehow re-confirmed our preliminary proposal; new possible sources appear by a additional correlated UHE-neutrino versus UHE-neutrino and-or with narrow UHECR clustering events. A possible role of relic neutrino mass scattering by ZeV neutrino arised.Comment: 6 pages, 5 figure

Upward Tau Air Showers from Earth

We estimate the rate of observable Horizontal and Upward Tau Air-Showers (HORTAUs, UPTAUS) considering both the Earth opacity and the finite size of the terrestrial atmosphere. We calculate the effective target volumes and masses for Tau air-showers emerging from the Earth. The resulting model-independent masses for satellite experiments such as EUSO may encompass at E_nu_tau = 10^19 eV a very large volume, V= 1020 km^3. Adopting simple power law neutrino fluxes, E^-2 and E^-1, calibrated to GZK-like and Z-Burst-like models, we estimate that at E= 10^19 eV nearly half a dozen horizontal shower events should be detected by EUSO in three years of data collection by the "guaranteed" GZK neutrino flux. We also find that the equivalent mass for an Earth outer layer made of rock is dominant compared to the water, contrary to simplified all-rock/all-water Earth models and previous Montecarlo simulations. Therefore we expect an enhancement of neutrino detection along continental shelves nearby the highest mountain chains, also given the better geometrical acceptance for Earth skimming neutrinos. The Auger experiment might reveal such a signature at E_nu= 10^{18} eV (with 26 events in 3 yr) towards the Andes, if the angular resolution at the horizon (both in azimuth and zenith) would reach an accuracy of nearly one degree needed to disentangle tau air showers from common UHECR. The number of events increases at lower energies; therefore we suggest an extension of the EUSO and Auger sensitivity down to (or even below) E_nu = 10^19 eV and E_nu = 10^18 eV respectively.Comment: New version resubmitted to ApJ on the 6th April 2004; 55 Pages,20 figures, major changes following referee reques

Approccio diagnostico-terapeutico della Sindrome di McCune-Albright

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UHECR Signatures and Sources

Abstract. We discuss recent results on the clustering, composition and distribution of Ultra-High Energy Cosmic Rays (UHECR) in the sky; from the energy of several tens of EeV in the dipole anisotropy, up to the highest energy of a few narrow clusters, those of Hot Spots. Following the early UHECR composition records deviations from proton, we noted that the UHECR events above 40 EeV can be made not just by any light or heavy nuclei, but mainly by the lightest ones as He,D, Li,Be. The remarkable Virgo absence and the few localized nearby extragalactic sources, such as CenA, NGC 253 and M82, are naturally understood: lightest UHECR nuclei cannot reach us from the Virgo distance of twenty Mpc, due to their nuclei fragility above a few Mpc distances. Their deflection and smearing in wide hot spots is better tuned to the lighter nuclei than to the preferred proton or heavy nuclei candidate courier. We note that these lightest nuclei still suffer of a partial photodistruction even from such close sources. Therefore, their distruption in fragments, within few tens EeV multiplet chain of events, have been expected and later on observed by Auger collaboration, nearly a decade ago. These multiplet presences, strongly correlate with the same CenA, NGC253 sources. The statistical weight of such correlation is reminded. We conclude that the same role of NGC 253 clustering at lower energies could also feed the Auger dipole anisotropy at lower energy ranges, integrated by nearest Vela, Crab, LMC and Cas A contributes. In our present UHECR model, based on lightest nuclei in local volumes of a few Mpcs, closest AGN, Star-Burst or very close SNR are superimposing their signals, frozen in different epochs, distances and directions, feeding small and wide anisotropy. Possible tests to confirm, or untangle the current model from alternative ones, are suggested and updated.Comment: 4 pages, 4 figure

Overproduction, crystallization and preliminary X-ray characterization of Abn2, an endo-1,5-alpha-arabinanase from Bacillus subtilis.

Acta Crystallographica F64 (2008) 636-638Two Bacillus subtilis extracellular endo-1,5-alpha-L-arabinanases, AbnA and Abn2, belonging to glycoside hydrolase family 43 have been identified. The recently characterized Abn2 protein hydrolyzes arabinan and has low identity to other reported 1,5-alpha-L-arabinanases. Abn2 and its selenomethionine (SeMet) derivative have been purified and crystallized. Crystals appeared in two different space groups: P1, with unit-cell parameters a = 51.9, b = 57.6, c = 86.2 A, alpha = 82.3, beta = 87.9, gamma = 63.6 degrees , and P2(1)2(1)2(1), with unit-cell parameters a = 57.9, b = 163.3, c = 202.0 A. X-ray data have been collected for the native and the SeMet derivative to 1.9 and 2.7 A resolution, respectively. An initial model of Abn2 is being built in the SeMet-phased map.This work was partially supported by grant No. POCI/AGR/60236/2004 from Fundacao para a Ciencia e Tecnologia (FCT) and FEDER to IdS-N and fellowship SFRH/BD/18238/2004 from FCT to JMI

Functional Implications of Second-Shell Basic Residues for dUTPase DR2231 Enzymatic Specificity

Nucleotide-processing enzymes are key players in biological processes. They often operate through high substrate specificity for catalysis. How such specificity is achieved is unclear. Here, we dea..