市民社会のプレーヤー交代劇と政治-仁平典宏の<贈与のパラドックス>論を読み解く-

千葉大学大学院人文社会科学研究科研究プロジェクト報告書第257集『都市コミュニティにおける相互扶助と次世代育成』水島治郎 編Sustainable Urban Communities: Communality and Generativity Report on the Research Projects No.25

Molecular photoacoustic imaging of follicular thyroid carcinoma

PURPOSE: To evaluate the potential of targeted photoacoustic imaging as a non-invasive method for detection of follicular thyroid carcinoma. EXPERIMENTAL DESIGN: We determined the presence and activity of two members of matrix metalloproteinase family (MMP), MMP-2 and MMP-9, suggested as biomarkers for malignant thyroid lesions, in FTC133 thyroid tumors subcutaneously implanted in nude mice. The imaging agent used to visualize tumors was MMP activatable photoacoustic probe, Alexa750-CXeeeeXPLGLAGrrrrrXK-BHQ3. Cleavage of the MMP activatable agent was imaged after intratumoral and intravenous injections in living mice optically, observing the increase in Alexa750 fluorescence, and photoacoustically, using a dual wavelength imaging method. RESULTS: Active forms of both MMP2 and MMP-9 enzymes were found in FTC133 tumor homogenates, with MMP-9 detected in greater amounts. The molecular imaging agent was determined to be activated by both enzymes in vitro, with MMP-9 being more efficient in this regard. Both optical and photoacoustic imaging showed significantly higher signal in tumors of mice injected with the active agent than in tumors injected with the control, non-activatable, agent. CONCLUSIONS: With the combination of high spatial resolution and signal specificity, targeted photoacoustic imaging holds great promise as a noninvasive method for early diagnosis of follicular thyroid carcinomas

Forest restoration in Europe : Deliverable 7.1 - Demo area workplans

This deliverable contains the 12 demonstrator area restoration workplans. The restoration workplans describe restoration sites, restoration goals and restoration activities for each demo area. The restoration measures will be integrated into the forest and landscape as much as possible. Additionally, the connections with other WPs such as WP2 – Stakeholders engagement and WP6 – Biodiversity monitoring are made within these restoration workplans.These workplans serve as a handbook, now for the demos themselves and later on for others who also work on the forest restoration. This deliverable includes the restoration workplans for the following demonstrator areas: Po Valley (Italy), southern Netherlands, North Moravia(Czech Republic), North Rhine Westphalia (Germany), Vindelälven-Juhttátahkka BiosphereReserve (Sweden), Queen Elizabeth Forest Park (Scotland), Biosphere Reserve BačkoPodunavlje (Croatia/Serbia cross-border), Făgăraș mountains (Romania), Thy andNordsjælland (Denmark), Castilla y Leon (Spain), Nouvelle-Aquitaine (France) and coppiceforests in Serbia

Additional file 3: Figure S1. of Development and clinical application of an integrative genomic approach to personalized cancer therapy

A decision tree approach to predict drug response based on genetic alterations. (PPTX 96 kb

Additional file 12: Figure S9A and B. of Development and clinical application of an integrative genomic approach to personalized cancer therapy

CLPB-NADSYN1 gene fusion in patient P0002. a Long-range PCR confirms CLPB-NADSYN1 gene fusion. b Genomic breakpoint of CLPB-NADSYN1 gene fusion. (ZIP 150 kb