The influence of estradiol and progesterone on neurocognition during three phases of the menstrual cycle: Modulating factors

This paper is dedicated to the memory of the first professor of Behavioral Endocrinology in the Faculty of Psychology at the University of Granada, Prof. Filomena Molina. We are grateful to Daniel Robert Caldera Jr. for his assistance with the English. This study was supported by the Spanish Ministry of Economy, Industry and Competitiveness (National I + D Plan: PSI2017-89324-C2-1-P and PSI2017-89324C2-2-P). Funding for open access charge: Universidad de Granada/CBUA.Estradiol is an ovarian steroid hormone that peaks shortly before ovulation and significantly affects various brain regions and neurotransmitter systems, with similar and differential effects with progesterone, another ovarian hormone. Studies investigating the neurocognitive processes during the menstrual cycle have focused on the early follicular phase (EFP) characterized by low estradiol and progesterone levels and the mid-luteal phase (MLP) with high estradiol and progesterone levels. However, most studies have failed to include the ovulatory phase, characterized by high estradiol and low progesterone levels. Given the various hormonal changes in the menstrual cycle, we revisited studies suggesting that the menstrual cycle did not affect verbal and spatial abilities and observed that many contain mixed results. Comparing these studies makes it possible to identify relevant modulating factors, such as sample size, participant age, accurate selection of days for testing, asymmetrical practice effects, genetic polymorphisms, and task difficulty. More robust findings are related to improved mental rotation capacity during EFP with challenging tasks and differences in brain activation among menstrual cycle phases during the execution of spatial and verbal tasks. During MLP, less robust findings were observed, possibly modulated by the complex effects of the two hormones on the brain. In conclusion, we propose that it is crucial to include all three menstrual cycle phases and consider these modulating factors to avoid confounding findings.Spanish Ministry of Economy, Industry and Competitiveness PSI2017-89324-C2-1-P PSI2017-89324C2-2-PUniversidad de Granada/CBU

Gender congruency between languages influence second-language comprehension: Behavioral and electrophysiological evidence

In the present study we explore whether gender congruency between languages modulates bilinguals’ access to their second language words presented in isolation. We predicted that accessing L2 words that have a different gender across languages (gender-incongruent) would be more costly and require more effort than accessing same-gender words (gender-congruent) due to language co-activation, even when no access to L1 was required to perform the task. Additionally, we intended to shed some light into the mechanism underlying the gender congruency effect. To these aims, we compared the performance of Spanish native speakers with that of Italian-Spanish bilinguals (Italian native speakers) during a lexical decision task. The participants saw Spanish words that were gender-congruent and gender-incongruent between languages while event related potentials were recorded. Moreover, as an additional manipulation, we selected nouns that in both languages could be ambiguous or unambiguous. With the aim to examine whether the underlying mechanism is activation of multiple information during word processing, we focused on the N400 component, related with the effort to integrate lexical-semantic information: higher N400 amplitudes indicate greater effort. According to our prediction, Italian-Spanish bilinguals produced more errors and evoked larger N400 amplitudes when accessing gender-incongruent than gender-congruent words, while no differences appeared for Spanish native speakers between conditions. These results indicate that gender-incongruent words are harder to integrate compared with gender-congruent words, and that bilinguals automatically activate the grammatical gender of both languages during L2 language comprehension. Nevertheless, the results do not seem to support the assumption of a similar mechanism responsible for the gender congruency and the ambiguity effects. In short, the gender-congruency effect seems to originate due to activation of multiple information at the lexical level which generates difficulties to integrate at the semantic level during word access.This work has been supported by Spanish Ministry of Science, Innovation and Universities (RED2018-102615-T), by Feder Andalucía (A-SEJ-416-UGR20) to D.P., by Spanish Ministry of Science and Innovation (PID2019-111359 GB-I00/AEI/10.13039/501100011033) and by the Universitat Rovira i Virgili to P. F. (2019PFR-URV-B2-32). Funding for open access charge: Universidad de Granada / CBUA

The scope of grammatical gender in Spanish: Transference to the conceptual level

This research was supported by grants, PCIN-2015-165-C02-01 and PSI2017-89324-C2-1 from the Spanish Ministry of Economy and Competitiveness. We want to thank the Jagiellonian University for providing open access, and the anonymous reviewers for their valuable comments.The aim of the present study was to explore under what circumstances we could observe a transference from grammatical gender to the conceptual representation of sex in Spanish, a two-gender language. The participants performed a lexical decision task and a gender decision task in the auditory modality, including words referencing inanimate entities associated with males or females. The sex stereotype could be congruent (falda [skirt], feminine) or incongruent (corbata [tie], feminine) with the grammatical gender. If the transfer from grammatical gender to conceptual information related to sex is settled, we should observed faster access for the congruent words compared with the incongruent ones both in the gender decision task and in the lexical decision task. The results showed a facilitation while processing congruent vs. incongruent words where attention to gender was mandatory during the adapted gender decision task. However, there was a lack of transference during the lexical decision task that might have been caused by the absence of direct conceptual activation by the time the decision was made. Additionally, we found that grammatical gender and sex-related information are closely connected, such as the indexical information about the sex of the speaker primes the activation of information related to sex at the conceptual (sex stereotype) and also at the lexical level (grammatical gender). Altogether, the results indicate that gender congruency effect is magnified by direct gender activation.Spanish Ministry of Economy and Competitiveness PCIN-2015-165-C02-01 PSI2017-89324-C2-

Grammatical Gender Inhibition in Bilinguals

Inhibitory control processes have been recently considered to be involved in interference resolution in bilinguals at the phonological level. In this study we explored if interference resolution is also carried out by this inhibitory mechanism at the grammatical level. Thirty-two bilinguals (Italian-L1 and Spanish-L2) participated. All of them completed two tasks. In the first one they had to name pictures in L2. We manipulated gender congruency between the two languages and the number of presentations of the pictures (1 and 5). Results showed a gender congruency effect with slower naming latencies in the incongruent condition. In the second task, participants were presented with the pictures practiced during the first naming task, but now they were asked to produce the L1 article. Results showed a grammatical gender congruency effect in L1 that increased for those words practiced five times in L2. Our conclusion is that an inhibitory mechanism was involved in the suppression of the native language during a picture naming task. Furthermore, this inhibitory process was also involved in suppressing grammatical gender when it was a source of competition between the languages

Exploring the nature of the gender-congruency effect: implicit gender activation and social bias

The aim of the study was to explore the nature of the gender-congruency effect, characterized by a facilitation on the processing of congruent words in grammatical gender. Moreover, we explored whether resemblances between gender identities and gender attitudes with grammatical gender modulated lexical processing. We designed a gender-priming paradigm in Spanish, in which participants decided the gender of a masculine or feminine pronoun preceded by three different primes: biological gender nouns (mapping biological sex), stereotypical nouns (mapping biological and stereotypical information), and epicene nouns (arbitrary gender assignment). We found faster processing of gender congruent pronouns independently of the type of prime, showing that the grammatical gender feature is active even when processing bare nouns that are not conceptually related to gender. This indicates that the gendercongruency effect is driven by the activation of the gender information at the lexical level, which is transferred to the semantic level. Interestingly, the results showed an asymmetry for epicene primes: the gender-congruency effect was smaller for epicene primes when preceding the feminine pronoun, probably driven by the grammatical rule of the masculine being the generic gender. Furthermore, we found that masculine oriented attitudes can bias language processing diminishing the activation of feminine gender, which ultimately could overshadow the female figureFEDER/Junta de Andalucía-Consejería de Economía y Conocimiento (A-SEJ- 416-UGR20)The Ministry of Science and Innovation (PID2019- 111359GBI00/AEI/10.13039/501100011033

Influence of sex, menstrual cycle, and hormonal contraceptives on egocentric navigation with or without landmarks

This study examines the influence of sex, menstrual cycle, hormonal contraceptives (HC) and sex hormone levels in following egocentric navigation instructions with or without landmarks. Estradiol seem to bias the reference frame for navigation during estrous cycle of female rats. However, previous studies in humans found no differences in overall navigation between women in their early follicular and mid-luteal menstrual cycle phases, whose performance was worse than that of men. Our study hypothesis was that the performance of women would be improved during the peri-ovulatory phase and would remain the same during placebo and active phases of HC users. The study included 21 men, 62 women with natural menstrual cycle (21 during early follicular phase, 20 during periovulatory phase, and 21 during mid-luteal phase), and 38 women that were receiving HC (13 during placebo phase and 25 during active phase). The men outperformed the women with a natural menstrual cycle when following egocentric instructions without landmarks. However, the women’s performance varied according to the phase of their menstrual cycle, differing from men during early follicular and mid-luteal phases but not during the peri-ovulatory phase. The use of HC also improved the performance of women to the extent that the difference with men disappeared. No differences were observed between HC-placebo and HC-active user groups during egocentric navigation without landmarks and among all groups during egocentric navigation with landmarks. Analysis of salivary hormones showed that testosterone levels were higher in men and that estradiol levels in women were higher during peri-ovulatory and mid-luteal phases and also in HC users. Progesterone levels were higher in women during the mid-luteal phase. These results appear compatible with beneficial effect of testosterone and estradiol on egocentric navigation without landmarks and with a block of this effect produced by progesterone

Cognitive and contextual factors modulating grammar learning at older ages

Second language learning has been shown more difficult for older than younger adults, however, the research trying to identify the sources of difficulty and possible modulating factors is scarce. Extrinsic (learning condition and complexity) and intrinsic factors (executive control) have been related to L2-grammar learning in younger adults. In the present study, we aim to assess whether extrinsic and intrinsic factors are also modulating grammar learning in older adults. We compared the learning performance of younger and older adults in a L2 learning task. 162 Spanish native-speakers (81 young) learnt Japañol (Japanese syntaxis and Spanish lexicon) in either an intentional (metalinguistic explanation) or an incidental (comprehension of sentences) context. The complexity of the sentences was also manipulated by introducing (or not) a subordinate clause. Individual differences in proactivity were measured with the AX-CPT task. After the learning phase, participants performed a Grammatical Judgment Task where they answered if the presented sentences were grammatically correct. No differences between older and younger adults were found. Overall, better results were found for the intentional-condition than for the incidental-condition. A significant interaction between learning context and the proactivity index in the AX-CPT task showed that more proactive participants were better when learning in the incidental-condition. These results suggest that both extrinsic and intrinsic factors are important during language learning and that they equally affect younger and older adults.Junta de AndaluciaMinisterio de Ciencia, Innovacion y Universidades-Agencia Estatal de Investigacion-Fondos Feder PGC2018-093786-BI00 A-SEJ-416-UGR20 PID2019-111359GB-I00/AEI/10.13039/501100011033Agencia de Desarrollo e Innovacion de Andalucia P20.00107Feder Andalucia A-CTS-111-UGR1

Exploring the nature of the gender-congruency effect: implicit gender activation and social bias

The aim of the study was to explore the nature of the gender-congruency effect, characterized by a facilitation on the processing of congruent words in grammatical gender. Moreover, we explored whether resemblances between gender identities and gender attitudes with grammatical gender modulated lexical processing. We designed a gender-priming paradigm in Spanish, in which participants decided the gender of a masculine or feminine pronoun preceded by three different primes: biological gender nouns (mapping biological sex), stereotypical nouns (mapping biological and stereotypical information), and epicene nouns (arbitrary gender assignment). We found faster processing of gender congruent pronouns independently of the type of prime, showing that the grammatical gender feature is active even when processing bare nouns that are not conceptually related to gender. This indicates that the gender-congruency effect is driven by the activation of the gender information at the lexical level, which is transferred to the semantic level. Interestingly, the results showed an asymmetry for epicene primes: the gender-congruency effect was smaller for epicene primes when preceding the feminine pronoun, probably driven by the grammatical rule of the masculine being the generic gender. Furthermore, we found that masculine oriented attitudes can bias language processing diminishing the activation of feminine gender, which ultimately could overshadow the female figure

The Influence of Cross-Linguistic Similarity and Language Background on Writing to Dictation

The current research was completed and thanks to financial aid provided by the doctoral research grant FPU16/01748 to AI and grants from the Ministerio de Ciencia, Innovacion y Universidades-Fondos Feder to TB (PGC2018-093786-B-I00) and DP (PCIN-2015-165-C02-01 and PSI2017-89324-C2-1-P) and from the Feder Andalucia to TB (A-CTS-111-UGR18 and P20.00107).This study used a word dictation task to examine the influence of a variety of factors on word writing production: cognate status (cognate vs. non-cognate words), orthographic (OS) and phonological similarity (PS) within the set of cognate words, and language learning background [late bilinguals (LBs) with academic literacy and formal instruction in English and Spanish, and heritage speakers (HSs) with academic literacy and formal instruction only in English]. Both accuracy and reaction times for the first key pressed by participants (indicating lexical access), and the time required to type the rest of the word after the first keypress (indicating sublexical processing) was assessed. The results revealed an effect of PS on the dictation task particularly for the first keypress. That is, cognates with high PS were processed faster than cognates with low PS. In contrast to reading studies in which PS only revealed a significant effect when the OS between languages was high (O + P+ vs. O + P−), in the dictation to writing task, the phonology had a more general effect across all conditions, regardless of the level of OS. On the other hand, OS tended to be more influential for typing the rest of the word. This pattern is interpreted as indicating the importance of phonology (and PS in cognates) for initial lexical retrieval when the input is aural. In addition, the role of OS and PS during co-activation was different between groups probably due to the participants’ linguistic learning environment. Concretely, HSs were found to show relatively lower OS effects, which is attributed to the greater emphasis on spoken language in their Spanish language learning experiences, compared to the formal education received by the LBs. Thus, the study demonstrates that PS can influence lexical processing of cognates, as long as the task demands specifically require phonological processing, and that variations in language learning experiences also modulate lexical processing in bilinguals.Ministerio de Ciencia, Innovacion y Universidades-Fondos Feder FPU16/01748Feder Andalucia PGC2018-093786-B-I00 PCIN-2015-165-C02-01 PSI2017-89324-C2-1-PA-CTS-111-UGR18 P20.0010

Transfer effects from language processing to visual attention dynamics: The impact of orthographic transparency

The consistency between letters and sounds varies across languages. These differences have been proposed to be associated with different reading mechanisms (lexical vs. phonological), processing grain sizes (coarse vs. fine) and attentional windows (whole words vs. individual letters). This study aimed to extend this idea to writing to dictation. For that purpose, we evaluated whether the use of different types of processing has a differential impact on local windowing attention: phonological (local) processing in a transparent language (Spanish) and lexical (global) processing of an opaque language (English). Spanish and English monolinguals (Experiment 1) and Spanish–English bilinguals (Experiment 2) performed a writing to dictation task followed by a global–local task. The first key performance showed a critical dissociation between languages: the response times (RTs) from the Spanish writing to dictation task was modulated by word length, whereas the RTs from the English writing to dictation task was modulated by word frequency and age of acquisition, as evidence that language transparency biases processing towards phonological or lexical strategies. In addition, after a Spanish task, participants more efficiently processed local information, which resulted in both the benefit of global congruent information and the reduced cost of incongruent global information. Additionally, the results showed that bilinguals adapt their attentional processing depending on the orthographic transparency.Doctoral Research Grant, Spanish Government FPU16/01748Feder Andalucia A-CTS111-UGR18 P20.00107Ministerio de Ciencia, Innovacion y Universidades-Fondos Feder A-SEJ-416-UGR20 PID2019-111359GB-I00/AEI/10.13039/501100011033 PGC2018-093786-B-I0