113 research outputs found
Programming in Restrictive Housing: Considerations for Improving Outcome Evaluations
A number of studies have identified “what works” in regard to the successful implementation of correctional programming over the past several decades. Few studies, however, have examined the complexities associated with programming in restrictive housing. Using data from a Midwestern department of corrections, we examined whether the provision of programming in restrictive housing achieved desired outcomes (e.g., reductions in inmate misconduct). The findings revealed the amount of time served in restrictive housing and confinement in different types of restrictive housing may influence estimations of a treatment effect. As a growing number of states seek to reform the use of restrictive housing, the proper implementation of cognitive-behavioral programming may increase institutional security and safety
Large deviations in boundary-driven systems: Numerical evaluation and effective large-scale behavior
We study rare events in systems of diffusive fields driven out of equilibrium
by the boundaries. We present a numerical technique and use it to calculate the
probabilities of rare events in one and two dimensions. Using this technique,
we show that the probability density of a slowly varying configuration can be
captured with a small number of long wave-length modes. For a configuration
which varies rapidly in space this description can be complemented by a local
equilibrium assumption
The Transformation Project: 2014 Annual Report
For years debate has rumbled in this country over prison overcrowding. More recently, there has been an additional spotlight on issues that are exacerbated when prisons are over capacity, such as prison rape and the use of restrictive housing (housing inmates in isolated conditions). In the case of prison rape, federal standards have been placed on institutions through the passage of the Prison Rape Elimination Act (PREA). General consensus among corrections professionals is that a lack of internal action diminished their voice during the creation of the PREA standards. There is consequently a large motivation for correctional institutions to work to address concerns regarding restrictive housing. Groups like Amnesty International, the American Civil Liberties Union and the Association of State Correctional Administrators have all been contributing to this effort by each creating their own guidelines for using restrictive housing. 2014 was a great opportunity for us to reflect on how Transformation Project (TP) will benefit institutions as they look to revise how they house inmates that are a threat to themselves or others. Not only does TP provide programming for restrictive housing, where there has historically been a dearth of programming, it works to increase the amount and quality of interaction between staff and participants, as well as provide a measure for assessing progress in restrictive housing. All of these efforts are included in the recommendations across invested organizations, adding additional value to TP curriculum. In addition to strengthening TP in restrictive housing, this year we began exploring ways the program can be modified for use in a women’s facility. While there is much work to be done in this area, we are excited to bring adaptions to the curriculum that will specifically address the needs of justice involved women. We look forward to continuing the development process with our partners at the Nebraska Correctional Center for Women in York, Nebraska, as this group has been instrumental to providing essential expertise and feedback. As debates around corrections issues roll on, in the coming months we look forward to solidifying TP’s role in the rehabilitation of inmates throughout the course of their incarceration
Aging in Models of Non-linear Diffusion
We show that for a family of problems described by non-linear diffusion
equations an exact calculation of the two time correlation function gives
C(t,t')=f(t-t')g(t'), t>t', exhibiting normal and anomalous diffusions, as well
as aging effects, depending on the degree of non-linearity. We discuss also the
form in which FDT is violated in this class of systems. Finally we argue that
in this type of models aging may be consequence of the non conservation of the
"total mass".Comment: 4 pages, 1 figure, to appear in Phys.Rev.
Cooperative Behavior of Kinetically Constrained Lattice Gas Models of Glassy Dynamics
Kinetically constrained lattice models of glasses introduced by Kob and
Andersen (KA) are analyzed. It is proved that only two behaviors are possible
on hypercubic lattices: either ergodicity at all densities or trivial
non-ergodicity, depending on the constraint parameter and the dimensionality.
But in the ergodic cases, the dynamics is shown to be intrinsically cooperative
at high densities giving rise to glassy dynamics as observed in simulations.
The cooperativity is characterized by two length scales whose behavior controls
finite-size effects: these are essential for interpreting simulations. In
contrast to hypercubic lattices, on Bethe lattices KA models undergo a
dynamical (jamming) phase transition at a critical density: this is
characterized by diverging time and length scales and a discontinuous jump in
the long-time limit of the density autocorrelation function. By analyzing
generalized Bethe lattices (with loops) that interpolate between hypercubic
lattices and standard Bethe lattices, the crossover between the dynamical
transition that exists on these lattices and its absence in the hypercubic
lattice limit is explored. Contact with earlier results are made via analysis
of the related Fredrickson-Andersen models, followed by brief discussions of
universality, of other approaches to glass transitions, and of some issues
relevant for experiments.Comment: 59 page
The Rover Environmental Monitoring Station Ground Temperature Sensor: A Pyrometer for Measuring Ground Temperature on Mars
We describe the parameters that drive the design and modeling of the Rover Environmental Monitoring Station (REMS) Ground Temperature Sensor (GTS), an instrument aboard NASA’s Mars Science Laboratory, and report preliminary test results. REMS GTS is a lightweight, low-power, and low cost pyrometer for measuring the Martian surface kinematic temperature. The sensor’s main feature is its innovative design, based on a simple mechanical structure with no moving parts. It includes an in-flight calibration system that permits sensor recalibration when sensor sensitivity has been degraded by deposition of dust over the optics. This paper provides the first results of a GTS engineering model working in a Martian-like, extreme environment
Non differentiable large-deviation functionals in boundary-driven diffusive systems
We study the probability of arbitrary density profiles in conserving
diffusive fields which are driven by the boundaries. We demonstrate the
existence of singularities in the large-deviation functional, the direct analog
of the free-energy in non-equilibrium systems. These singularities are unique
to non-equilibrium systems and are a direct consequence of the breaking of
time-reversal symmetry. This is demonstrated in an exactly-solvable model and
also in numerical simulations on a boundary-driven Ising model. We argue that
this singular behavior is expected to occur in models where the compressibility
has a deep enough minimum. The mechanism is explained using a simple model.Comment: 5 pages, 3 figure
PSMA-PET/CT-guided salvage radiotherapy in recurrent or persistent prostate cancer and PSA < 0.2 ng/ml.
PURPOSE
The purpose of this retrospective, multicenter study was to assess efficacy of PSMA-PET/CT-guided salvage radiotherapy (sRT) in patients with recurrent or persistent PSA after primary surgery and PSA levels < 0.2 ng/ml.
METHODS
The study included patients from a pooled cohort (n = 1223) of 11 centers from 6 countries. Patients with PSA levels > 0.2 ng/ml prior to sRT or without sRT to the prostatic fossa were excluded. The primary study endpoint was biochemical recurrence-free survival (BRFS) and BR was defined as PSA nadir after sRT + 0.2 ng/ml. Cox regression analysis was performed to assess the impact of clinical parameters on BRFS. Recurrence patterns after sRT were analyzed.
RESULTS
The final cohort consisted of 273 patients; 78/273 (28.6%) and 48/273 (17.6%) patients had local or nodal recurrence on PET/CT. The most frequently applied sRT dose to the prostatic fossa was 66-70 Gy (n = 143/273, 52.4%). SRT to pelvic lymphatics was delivered in 87/273 (31.9%) patients and androgen deprivation therapy was given to 36/273 (13.2%) patients. After a median follow-up time of 31.1 months (IQR: 20-44), 60/273 (22%) patients had biochemical recurrence. The 2- and 3-year BRFS was 90.1% and 79.2%, respectively. The presence of seminal vesicle invasion in surgery (p = 0.019) and local recurrences in PET/CT (p = 0.039) had a significant impact on BR in multivariate analysis. In 16 patients, information on recurrence patterns on PSMA-PET/CT after sRT was available and one had recurrent disease inside the RT field.
CONCLUSION
This multicenter analysis suggests that implementation of PSMA-PET/CT imaging for sRT guidance might be of benefit for patients with very low PSA levels after surgery due to promising BRFS rates and a low number of relapses within the sRT field
The prognostic significance of a negative PSMA-PET scan prior to salvage radiotherapy following radical prostatectomy.
AIM
The optimal management for early recurrent prostate cancer following radical prostatectomy (RP) in patients with negative prostate-specific membrane antigen positron-emission tomography (PSMA-PET) scan is an ongoing subject of debate. The aim of this study was to evaluate the outcome of salvage radiotherapy (SRT) in patients with biochemical recurrence with negative PSMA PET finding.
METHODS
This retrospective, multicenter (11 centers, 5 countries) analysis included patients who underwent SRT following biochemical recurrence (BR) of PC after RP without evidence of disease on PSMA-PET staging. Biochemical recurrence-free survival (bRFS), metastatic-free survival (MFS) and overall survival (OS) were assessed using Kaplan-Meier method. Multivariable Cox proportional hazards regression assessed predefined predictors of survival outcomes.
RESULTS
Three hundred patients were included, 253 (84.3%) received SRT to the prostate bed only, 46 (15.3%) additional elective pelvic nodal irradiation, respectively. Only 41 patients (13.7%) received concomitant androgen deprivation therapy (ADT). Median follow-up after SRT was 33 months (IQR: 20-46 months). Three-year bRFS, MFS, and OS following SRT were 73.9%, 87.8%, and 99.1%, respectively. Three-year bRFS was 77.5% and 48.3% for patients with PSA levels before PSMA-PET ≤ 0.5 ng/ml and > 0.5 ng/ml, respectively. Using univariate analysis, the International Society of Urological Pathology (ISUP) grade > 2 (p = 0.006), metastatic pelvic lymph nodes at surgery (p = 0.032), seminal vesicle involvement (p 0.5 ng/ml (p = 0.004), and lack of concomitant ADT (p = 0.023) were significantly associated with worse bRFS. On multivariate Cox proportional hazards, seminal vesicle infiltration (p = 0.007), ISUP score >2 (p = 0.048), and pre SRT PSA level > 0.5 ng/ml (p = 0.013) remained significantly associated with worse bRFS.
CONCLUSION
Favorable bRFS after SRT in patients with BR and negative PSMA-PET following RP was achieved. These data support the usage of early SRT for patients with negative PSMA-PET findings
A Multicenter Evaluation of Different Chemotherapy Regimens in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Chemoradiation
PURPOSE: The number of older adults with head-and-neck squamous cell carcinoma (HNSCC) is increasing, and treatment of these patients is challenging. Although cisplatin-based chemotherapy concomitantly with radiotherapy is considered standard regimen for patients with locoregionally advanced HNSCC, there is substantial real-world heterogeneity regarding concomitant chemotherapy in older HNSCC patients.
METHODS: The XXX study is an international multicenter cohort study including older (≥65 years) HNSCC patients treated with definitive radiotherapy at 13 academic centers in the United States and Europe. Here, patients with concomitant chemoradiation were analyzed regarding overall survival (OS) and progression-free survival (PFS) using Kaplan-Meier analyses, while Fine-Gray competing risks regressions were performed regarding the incidence of locoregional failures (LRFs) and distant metastases (DMs).
RESULTS: Six hundred ninety-seven patients with a median age of 71 years were included in this analysis. Single-agent cisplatin was the most common chemotherapy regimen (n=310; 44%), followed by cisplatin plus 5-fluorouracil (n=137; 20%), carboplatin (n=73; 10%), and mitomycin c plus 5-fluorouracil (n=64; 9%). Carboplatin-based regimens were associated with diminished PFS (HR=1.39 [1.03-1.89], p.05). Median cumulative dose of cisplatin was 180 mg/m2 (IQR, 120-200 mg/m2). Cumulative cisplatin doses ≥200 mg/m2 were associated with increased OS (HR=0.71 [0.53-0.95], p=.02), PFS (HR=0.66 [0.51-0.87], p=.003), and lower incidence of LRFs (SHR=0.50 [0.31-0.80], p=.004). Higher cumulative cisplatin doses remained an independent prognostic variable in the multivariate regression analysis for OS (HR=0.996 [0.993-0.999], p=.009).
CONCLUSIONS: Single-agent cisplatin can be considered as the standard chemotherapy regimen for older HNSCC patients who can tolerate cisplatin. Cumulative cisplatin doses are prognostically relevant also in older HNSCC patients
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