Double Polarization Observables in Pentaquark Photoproduction

We investigate the properties of the hidden charm pentaquark-like resonances first observed by LHCb in 2015, by measuring the polarization transfer KLL between the incident photon and the outgoing proton in the exclusive photoproduction of J/psi near threshold. We present a first estimate of the sensitivity of this observable to the pentaquark photocouplings and hadronic branching ratios, and extend our predictions to the case of initial state helicity correlation ALL, using a polarized target. These results serve as a benchmark for the SBS experiment at Jefferson Lab, which proposes to measure for the first time the helicity correlations ALL and KLL in J/psi exclusive photoproduction, in order to determine the pentaquark photocouplings and branching ratios.Comment: 9 pages, 7 figures, 2 tables, Version published in PR

Dynamics in near-threshold J/ψ photoproduction

The study of J/ψ photoproduction at low energies has consequences for the understanding of multiple aspects of nonperturbative QCD, ranging from mechanical properties of the proton to the binding inside nuclei and the existence of hidden-charm pentaquarks. Factorization of the photon-c¯c and nucleon dynamics or vector meson dominance are often invoked to justify these studies. Alternatively, open-charm intermediate states have been proposed as the dominant mechanism underlying J/ψ photoproduction. As the latter violates this factorization, it is important to estimate the relevance of such contributions. We analyze the latest differential and integrated photoproduction cross sections from the GlueX and J/ψ−007 experiments. We show that the data can be adequately described by a small number of partial waves, which we parametrize with generic models enforcing low-energy unitarity. The results suggest a non-negligible contribution from open-charm intermediate states. Furthermore, most of the models present an elastic scattering length incompatible with previous extractions based on vector meson dominance and thus call into question its applicability to heavy mesons. Our results indicate a wide array of physics possibilities that are compatible with present data and need to be disentangled

Longitudinal trends in renal function among first time sugarcane harvesters in Guatemala.

IntroductionChronic kidney disease of unknown origin (CKDu) is an epidemic concentrated in agricultural communities in Central and South America, including young, male sugarcane harvesters. The purpose of this analysis is to understand early changes in kidney function among a cohort of first-time sugarcane harvesters and to determine risk factors for kidney function decline.MethodsJoint latent class mixed models were used to model sub-population kidney function trajectory over the course of 4 years (2012-2016). Probability weighted logistic regression was used to determine personal health, community, and individual behavior risk factors associated with sub-population assignment. Data analysis occurred in 2019.ResultsOf 181 new workers median age 19 years old (IQR: 4), 39 (22%) were identified as having non-stable kidney function with an annual age-adjusted decline of estimated glomerular filtration rate (eGFR) of -1.0 ml/min per 1.73 m2 (95% CI: -3.4, 1.3). Kidney function (OR: 0.96; 95% CI: 0.93, 0.98), mild hypertension (OR: 5.21; 95% CI: 2.14, 13.94), and having a local home of residence (OR: 7.12; 95% CI: 2.41, 26.02) prior to employment in sugarcane were associated with non-stable eGFR sub-population assignment.ConclusionsMild hypertension may be an early indicator of the development of CKDu. A better understanding of preexisting risk factors is needed to determine why individuals are entering the workforce with reduced kidney function and elevated blood pressure and increased risk of renal function decline

Double polarization observables in pentaquark photoproduction

We investigate the properties of the hidden-charm pentaquark-like resonances first observed by the LHCb Collaboration in 2015, by measuring the polarization transfer KLL between the incident photon and the outgoing proton in the exclusive photoproduction of J=ψ near threshold. We present a first estimate of the sensitivity of this observable to the pentaquark photocouplings and hadronic branching ratios, and extend our predictions to the case of the initial-state helicity correlation ALL, using a polarized target. These results serve as a benchmark for the SBS experiment at Jefferson Lab, which proposes to measure for the first time the helicity correlations ALL and KLL in J=ψ exclusive photoproduction, in order to determine the pentaquark photocouplings and branching ratios

Point-of-Care Testing in Chronic Kidney Disease of Non-Traditional Origin: Considerations for Clinical, Epidemiological, and Health Surveillance Research and Practice

Purpose: As the prevalence of chronic kidney disease of non-traditional origin (CKDnt) rises in low-resource settings, there is a need for reliable point-of-care creatinine testing. The purpose of this analysis was to assess the accuracy of two commonly used point-of-care creatinine devices, the i-STAT handheld (Abbott, Princeton, NJ, USA) and the StatSensor Creatinine (Nova Biomedical, Waltham, MA, USA) in comparison to venipuncture serum creatinine measures. The affordability, sensitivity, specificity, ease of use, and other considerations for each device are also presented. Methods: Three paired data sets were compared. We collected 213 paired i-STAT and venipuncture samples from a community study in Nicaragua in 2015–2016. We also collected 267 paired StatSensor Creatinine and venipuncture samples, including 158 from a community setting in Nicaragua in 2014–2015 and 109 from a Guatemala sugarcane worker cohort in 2017–2018. Pearson correlation coefficients, Bland-Altman plots, and no intercept linear regression models were used to assess agreement between point-of-care devices and blood samples. Results: The i-STAT performed the most accurately, overestimating creatinine by 0.07 mg/dL (95% CI: 0.02, 0.12) with no evidence of proportional bias. The StatSensor Creatinine performed well at low levels of creatinine (Mean (SD): 0.87 (0.19)). Due to proportional bias, the StatSensor Creatinine performed worse in the Nicaragua community setting where creatinine values ranged from 0.31 to 7.04 mg/dL. Discussion: Both devices provide acceptable sensitivity and specificity. Although adequate for routine surveillance, StatSensor Creatinine is less accurate as the values of measured creatinine increase, a consideration when using the point-of-care device for screening individuals at risk for CKDnt. Research, clinical, and screening objectives, cost, ease of use, and background prevalence of disease must all be carefully considered when selecting a point-of-care creatinine device. Conclusion: POC testing can be more accessible in resource-limited settings. The selection of the appropriate device will depend on the use-case

Body Composition, Anemia, and Kidney Function among Guatemalan Sugarcane Workers

Rates of anemia among agricultural workers, who are also at risk for kidney injury and chronic kidney disease of unknown cause (CKDu), are unknown. We evaluated body composition through the sum of three skinfolds among 203 male sugarcane cutters and assessed the relationship of variables related to nutrition, anemia (hemoglobin < 13 g/dL), and elevated hemoglobin A1c (HbA1c ≥ 5.7%) with estimated glomerular filtration rate (eGFR) using linear regression. Eleven percent of workers were at the level of essential body fat (2–5%). Anemia was present among 13% of workers, 70% of which were normochromic normocytic, a type of anemia suggesting potential underlying chronic disease. Anemia was more common among those with lower BMI and fat free mass. The prevalence of elevated HbA1c was 21%. A moderate negative correlation was found between hemoglobin and HbA1c (Pearson’s r = −0.32, p < 0.01) which suggests that HbA1c values should be interpreted with caution in populations that have high rates of anemia. Twelve percent of workers had reduced kidney function with an eGFR < 90 mL/min/1.73 m2. On average, the eGFR was 18 mL/min per 1.73 m2 lower [(95% CI:−24, −12), p < 0.01)] for those with anemia than those without, and 8 mL/min per 1.73 m2 lower among those with elevated HbA1c [(95% CI: −13, −2), p < 0.01]. Results will inform future studies examining the role of anemia in the evaluation of CKDu and interventions to improve nutrition for workers in low-resource settings

Urinary concentrations of metals before and after volcanic eruption: a natural experiment surrounding the eruption of Volcán de Fuego, 2018

Volcanic eruptions increase environmental heavy metal concentrations, yet little research has been performed on their extrapulmonary human health effects. We fortuitously collected biological samples in a cohort of Guatemalan sugarcane cutters in the area surrounding Volcán de Fuego before and after the June 2018 eruption. We sought to determine whether stratovolcanic activity was associated with changes in urinary concentrations of heavy metals in a cohort of sugarcane workers. In this exploratory analysis, we found significant increases in urinary arsenic, (β = 1.46, P \u3c 0.0001), cadmium (β = 1.03, P \u3c 0.0001), and lead (β = 0.87, P = 0.003) in participants with residential proximity to Volcán de Fuego as compared to participants farther away, suggesting that volcanic activity could be associated with acute heavy metal exposures. This natural experiment is, to our knowledge, the first of its kind and suggests a need for more research into heavy metal exposure-related health impacts of volcanic eruptions

International Total Worker Health: Applicability to Agribusiness in Latin America

Total Worker Health® (TWH) is a framework for integrating worker and workplace safety, health, and well-being, which has achieved success in European and US settings. However, the framework has not been implemented in Latin America or in agricultural sectors, leaving large and vulnerable populations underrepresented in the implementation and evaluation of these strategies to improve safety and promote health and well-being. This study presents a case study of how a TWH approach can be applied to a multinational Latin American agribusiness. We describe the process and adaptation strategy for conducting a TWH assessment at multiple organizational levels and in multiple countries. We follow this with a description of a TWH leadership training that was conducted based on the results of the assessment. Finally, we describe our methods to make corporate recommendations for TWH policies and programs that were informed by the TWH assessment and leadership trainings. With this case study we aim to demonstrate the importance and feasibility of conducting TWH in Latin America

Physiological and genetic control of transpiration efficiency in African rice, Oryza glaberrima Steud

International audienceImproving crop water use efficiency, the amount of carbon assimilated as biomass per unit of water used by a plant, is of major importance as water for agriculture becomes scarcer. In rice, the genetic bases of transpiration efficiency, the derivation of water use efficiency at the whole-plant scale, and its putative component trait transpiration restriction under high evaporative demand remain unknown. These traits were measured in 2019 in a panel of 147 African rice (Oryza glaberrima) genotypes known to be potential sources of tolerance genes to biotic and abiotic stresses. Our results reveal that higher transpiration efficiency is associated with transpiration restriction in African rice. Detailed measurements in a subset of highly contrasted genotypes in terms of biomass accumulation and transpiration confirmed these associations and suggested that root to shoot ratio played an important role in transpiration restriction. Genome wide association studies identified marker-trait associations for transpiration response to evaporative demand, transpiration efficiency, and its residuals, with links to genes involved in water transport and cell wall patterning. Our data suggest that root–shoot partitioning is an important component of transpiration restriction that has a positive effect on transpiration efficiency in African rice. Both traits are heritable and define targets for breeding rice with improved water use strategies

Novel approaches in Hadron Spectroscopy

The last two decades have witnessed the discovery of a myriad of new and unexpected hadrons. The future holds more surprises for us, thanks to new-generation experiments. Understanding the signals and determining the properties of the states requires a parallel theoretical effort. To make full use of available and forthcoming data, a careful amplitude modeling is required, together with a sound treatment of the statistical uncertainties, and a systematic survey of the model dependencies. We review the contributions made by the Joint Physics Analysis Center to the field of hadron spectroscopy.Comment: 98 pages, 58 figures. To appear in Progress in Particle and Nuclear Physic