THE VALUE OF THE MARKETPLACE OF IDEAS: ACADEMIC FREEDOM IN THE AMERICAN ACADEMY

This dissertation surveys several landmark U.S. Supreme Court cases of academic freedom in the 20th and 21st century to argue for the value of a tolerant and liberal interpretation of unrestricted academic freedom. Central to its argument is a defense of Oliver Wendell Holmes 1919 ruling in Abrams that society is best served where all expressions are tested in a “marketplace of ideas,” a term first used by John Stuart Mill in his 1859 essay, “On Liberty.” In an era of increasing casualization of academic labor (the adjunct labor force) and political paranoia about terror, I conclude that the continual defense and affirmation of academic freedom as a concept is particularly necessary to counterbalance repressive forces on academic knowledge production. I argue that the idea of academic freedom in America, expressed in the American Association of University Professor\u27s 1940 Statement of Principles on Academic Freedom and Tenure, has been greatly limited by social and political developments in the 20th and 21st centuries. The consequence of the erosion of academic freedom within the American academy is that generations of future students will not question or challenge the status quo. By looking at the erosion of academic freedom, I will argue that the philosophical basis of academic freedom must reside in the “marketplace of ideas,” and that contemporary labor practices threaten to extinguish academic freedom as it has been defined for over 100 years

El análisis antisténico de los nombres. Un modelo nominalista

A. Brancacci (1990) ha interpretado y reconstruido la filosofía de Antístenes de Atenas en clave semántica, negando el nominalismo antisténico y acentuando el carácter vincular que el método antisténico de investigación filosófica establece entre la habilidad retórica y el saber moral. La interpretación de Brancacci se ha tornado canónica; sin embargo, los pasajes antisténicos referidos al análisis de los nombres parecen más bien el ejemplo de una filosofía nominalista (en el sentido que la expresión ‘nominalista’ cobrara en las disputas del siglo XII sobre el estatuto de los términos universales) que un modelo exclusivamente destinado al análisis semántico de conceptos

El análisis antisténico de los nombres. Un modelo nominalista

A. Brancacci (1990) ha interpretado y reconstruido la filosofía de Antístenes de Atenas en clave semántica, negando el nominalismo antisténico y acentuando el carácter vincular que el método antisténico de investigación filosófica establece entre la habilidad retórica y el saber moral. La interpretación de Brancacci se ha tornado canónica; sin embargo, los pasajes antisténicos referidos al análisis de los nombres parecen más bien el ejemplo de una filosofía nominalista (en el sentido que la expresión ‘nominalista’ cobrara en las disputas del siglo XII sobre el estatuto de los términos universales) que un modelo exclusivamente destinado al análisis semántico de conceptos

Vasotocin Actions on Electric Behavior: Interspecific, Seasonal, and Social Context-Dependent Differences

Social behavior diversity is correlated with distinctively distributed patterns of a conserved brain network, which depend on the action of neuroendocrine messengers that integrate extrinsic and intrinsic cues. Arginine vasotocin (AVT) is a key integrator underlying differences in behavior across vertebrate taxa. Weakly electric fish use their electric organ discharges (EODs) as social behavioral displays. We examined the effect of AVT on EOD rate in two species of Gymnotiformes with different social strategies: Gymnotus omarorum, territorial and highly aggressive, and Brachyhypopomus gauderio, gregarious and aggressive only between breeding males. AVT induced a long-lasting and progressive increase of EOD rate in isolated B. gauderio, partially blocked by the V1a AVT receptor antagonist (Manning compound, MC), and had no effects in G. omarorum. AVT also induced a long-lasting increase in the firing rate (prevented by MC) of the isolated medullary pacemaker nucleus (PN) of B. gauderio when tested in an in vitro preparation, indicating that the PN is the direct effector of AVT actions. AVT is involved in the seasonal, social context-dependent nocturnal increase of EOD rate that has been recently described in B. gauderio to play a role in mate selection. AVT produced the additional nocturnal increase of EOD rate in non-breeding males, whereas MC blocked it in breeding males. Also, AVT induced a larger EOD rate increase in reproductive dyads than in agonistic encounters. We demonstrated interspecific, seasonal, and context-dependent actions of AVT on the PN that contribute to the understanding of the mechanisms the brain uses to shape sociality

“Contra todo el torrente de mi razón”. Resistencia y representación del Intendente José Francisco Bermúdez en la República de Colombia (1822)

Durante su gestión en las provincias orientales de Venezuela reunidas en el Departamento Orinoco de la República de Colombia, el Intendente, General José Francisco Bermúdez, demostró tener juicio propio en la aplicación de las leyes y resoluciones emanadas de las autoridades superiores del gobierno, llegando incluso al extremo de criticarlas o desobedecerlas cuando las estimó perniciosas para los pueblos que regía. Con ello desbordó las facultades que le confería el ordenamiento jurídico; pero el papel que asumió como representante de los pueblos orientales justificaba, en su parecer, tal actitud. En este trabajo analizamos tres casos que reflejaron esta conducta y proponemos, al mismo tiempo, explicaciones de naturaleza institucional y personal para su mejor comprensión

Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae

<p>Abstract</p> <p>Background</p> <p>Protein-SH groups are amongst the most easily oxidized residues in proteins, but irreversible oxidation can be prevented by protein glutathionylation, in which protein-SH groups form mixed disulphides with glutathione. Glutaredoxins and thioredoxins are key oxidoreductases which have been implicated in regulating glutathionylation/deglutathionylation in diverse organisms. Glutaredoxins have been proposed to be the predominant deglutathionylase enzymes in many plant and mammalian species, whereas, thioredoxins have generally been thought to be relatively inefficient in deglutathionylation.</p> <p>Results</p> <p>We show here that the levels of glutathionylated proteins in yeast are regulated in parallel with the growth cycle, and are maximal during stationary phase growth. This increase in glutathionylation is not a response to increased reactive oxygen species generated from the shift to respiratory metabolism, but appears to be a general response to starvation conditions. Our data indicate that glutathionylation levels are constitutively high in all growth phases in thioredoxin mutants and are unaffected in glutaredoxin mutants. We have confirmed that thioredoxins, but not glutaredoxins, catalyse deglutathionylation of model glutathionylated substrates using purified thioredoxin and glutaredoxin proteins. Furthermore, we show that the deglutathionylase activity of thioredoxins is required to reduce the high levels of glutathionylation in stationary phase cells, which occurs as cells exit stationary phase and resume vegetative growth.</p> <p>Conclusions</p> <p>There is increasing evidence that the thioredoxin and glutathione redox systems have overlapping functions and these present data indicate that the thioredoxin system plays a key role in regulating the modification of proteins by the glutathione system.</p

National Variation in Opioid Prescribing and Risk of Prolonged Use for Opioid-Naive Patients Treated in the Emergency Department for Ankle Sprains

Between 2011 and 2015, nearly one in four patients with ankle sprains were prescribed opioids in the emergency department. The overall prescribing rate declined during the study period, but varied significantly by state, ranging from 2.8% in North Dakota to 40% in Arkansas. Patients prescribed the largest amounts of opioid were nearly five times more likely to transition to continued use as those prescribed lesser amounts

Transmigration of Trypanosoma cruzi trypomastigotes through 3D cultures resembling a physiological environment

To disseminate and colonise tissues in the mammalian host, Trypanosoma cruzi trypomastogotes should cross several biological barriers. How this process occurs or its impact in the outcome of the disease is largely speculative. We examined the in vitro transmigration of trypomastigotes through three-dimensional cultures (spheroids) to understand the tissular dissemination of different T. cruzi strains. Virulent strains were highly invasive: trypomastigotes deeply transmigrate up to 50 μm inside spheroids and were evenly distributed at the spheroid surface. Parasites inside spheroids were systematically observed in the space between cells suggesting a paracellular route of transmigration. On the contrary, poorly virulent strains presented a weak migratory capacity and remained in the external layers of spheroids with a patch-like distribution pattern. The invasiveness—understood as the ability to transmigrate deep into spheroids—was not a transferable feature between strains, neither by soluble or secreted factors nor by co-cultivation of trypomastigotes from invasive and non-invasive strains. Besides, we demonstrated that T. cruzi isolates from children that were born congenitally infected presented a highly migrant phenotype while an isolate from an infected mother (that never transmitted the infection to any of her children) presented significantly less migration. In brief, we demonstrated that in a 3D microenvironment each strain presents a characteristic migration pattern that can be associated to their in vivo behaviour. Altogether, data presented here repositionate spheroids as a valuable tool to study host–pathogen interactions.Fil: Rodriguez, Matias Exequiel. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Rizzi, Mariana. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Caeiro, Lucas Daniel. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Masip, Yamil Ezequiel. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Perrone, Alina Elizabeth. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sanchez, Daniel Oscar. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Bua, Jacqueline Elena. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tekiel, Valeria Sonia. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentin