Preservación y difusión digital del acervo cultural saharaui

En este trabajo, se busca dar solución a una problemática generada del uso de descripción ambigua en una colección de documentos. La temática general cubierta gira en torno al acervo cultural saharaui, específicamente el musical, y las consecuencias en la cultura de una guerra en el Sáhara Occidental. Definiremos un sistema de descripción que permita mantener el control sobre los términos y facilite las búsquedas. Además, se recogerá el aporte de recursos y términos que hagan los usuarios. En último lugar, difundiremos el proyecto a través de una página web específicamente adaptada a las necesidades básicas para registrar usuarios y recursos.In this work, we seek to solve a problem derived from the ambiguous use of keywords in a collection of documents. The main topic is about the Saharawi cultural heritage, more specifically related to its music and the cultural consequences of a war in Western Sahara. We will develop a description system in order to keep control over the keywords as well as improving the searching process. In addition to that, the contribution of resources and keywords made by users will be collected. Finally, we will disseminate the project through a customised web page, focused on the basic needs to register users and resources

INCORPORATION OF NANOCLAY AND ORANGE PEELS EXTRACT INTO PLA FOR FOOD APPLICATIONS: MIGRATION ASSESSMENT

This research investigated the overall and specific migration from two different formulations of PLA: one obtained with addition of nanoclay as a filler (PLA_Clay), and another one obtained with the addition of an antioxidant extract from waste orange peels (OPE) as an active component for food application (PLA_OPE). Overall migration was always below the current European limit of 10 mg/dm2 set for food contact materials (maximum 0.2 mg/dm2 from PLA_Clay into distilled water and 2.7 mg/dm2 from PLA_OPE into 3 % acetic acid). Specific migration of clay elements and particles from PLA_Clay was evaluated by different techniques (atomic absorption spectroscopy, SEM and SEM microanalysis). A very limited release of clay elements was measured, with the highest migration found for calcium. SEM observation showed the release of particles also of size \u3c 1 µm. The migration testing conditions of 10 days at 40 °C showed a swelling of the PLA which was enhanced by nanoclay presence. A maximum 2.5 % of the phenolic compounds of the incorporated OPE were released in the simulant 20 % ethanol, which is compatible with the fact that the OPE had been obtained through aqueous ethanol extraction

Is it necessary to show virtual limbs in action observation neurorehabilitation systems?

Action observation neurorehabilitation systems are usually based on the observation of a virtual limb performing different kinds of actions. In this way, the activity in the frontoparietal Mirror Neuron System is enhanced, which can be helpful to rehabilitate stroke patients. However, the presence of limbs in such systems might not be necessary to produce mirror activity, for example, frontoparietal mirror activity can be produced just by the observation of virtual tool movements. The objective of this work was to explore to what point the presence of a virtual limb impacts the Mirror Neuron System activity in neurorehabilitation systems.info:eu-repo/semantics/publishedVersio

Diagnosis of Dengue Virus Infection by the Visual and Simple AuBioDOT Immunoglobulin M Capture System

The Dengue IgM Capture ELISA (MAC-ELISA) is the immunoenzymatic system recommended by the Pan American Health Organization and the World Health Organization for the serological diagnosis of dengue virus infection due to its high sensitivity, ease of performance, and use of a single acute-phase serum sample. However, tests with this enzyme-linked immunosorbent assay (ELISA) system are time-consuming and require equipment for washing, incubation, and reading of the results. AuBioDOT is a multistep visual diagnostic immunoassay that uses technology based on the immunoglobulin M (IgM) capture ELISA principle. This system uses white polyethylene opaque plates as the solid phase, colloidal gold as the marker, and silver ion amplification. It does not require special equipment, it is totally manually operated, and it can be performed in less than 1 h. The sensitivity and specificity of AuBioDOT for the detection of anti-dengue virus IgM antibodies were studied with a panel of 336 serum samples (150 serum samples from patients with suspected or serologically confirmed dengue virus infection, 186 serum samples from healthy blood donors and patients without dengue virus infection). The results were compared with those obtained by the MAC-ELISA. A sensitivity of 97.7% and a specificity of 97.1% were obtained. The concordance of the two tests was 97.3%, with a kappa index of 0.94. The application of AuBioDOT for the detection of anti-dengue virus IgM antibodies is recommended as an alternative method for the diagnosis of dengue virus infection, both for clinical diagnosis and for seroepidemiological surveillance. The system is useful under field conditions and in laboratories and requires little equipment

Le bruit des equipements du genie climatique

Ce rapport devrait comporter 3 volumes : nous n'en possedons que 2.Available from INIST (FR), Document Supply Service, under shelf-number : RP 400 (2186)(1); RP 400 (2186)(2) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEAgence de l'Environnement et de la Maitrise de l'Energie (ADEME), 92 - Vanves (France)FRFranc

Gene expression profiling unveils the temporal dynamics of CIGB-300-regulated transcriptome in AML cell lines

Abstract Background Protein kinase CK2 activity is implicated in the pathogenesis of various hematological malignancies like Acute Myeloid Leukemia (AML) that remains challenging concerning treatment. This kinase has emerged as an attractive molecular target in therapeutic. Antitumoral peptide CIGB-300 blocks CK2 phospho-acceptor sites on their substrates but it also binds to CK2α catalytic subunit. Previous proteomic and phosphoproteomic experiments showed molecular and cellular processes with relevance for the peptide action in diverse AML backgrounds but earlier transcriptional level events might also support the CIGB-300 anti-leukemic effect. Here we used a Clariom S HT assay for gene expression profiling to study the molecular events supporting the anti-leukemic effect of CIGB-300 peptide on HL-60 and OCI-AML3 cell lines. Results We found 183 and 802 genes appeared significantly modulated in HL-60 cells at 30 min and 3 h of incubation with CIGB-300 for p   = │1.5│, respectively; while 221 and 332 genes appeared modulated in OCI-AML3 cells. Importantly, functional enrichment analysis evidenced that genes and transcription factors related to apoptosis, cell cycle, leukocyte differentiation, signaling by cytokines/interleukins, and NF-kB, TNF signaling pathways were significantly represented in AML cells transcriptomic profiles. The influence of CIGB-300 on these biological processes and pathways is dependent on the cellular background, in the first place, and treatment duration. Of note, the impact of the peptide on NF-kB signaling was corroborated by the quantification of selected NF-kB target genes, as well as the measurement of p50 binding activity and soluble TNF-α induction. Quantification of CSF1/M-CSF and CDKN1A/P21 by qPCR supports peptide effects on differentiation and cell cycle. Conclusions We explored for the first time the temporal dynamics of the gene expression profile regulated by CIGB-300 which, along with the antiproliferative mechanism, can stimulate immune responses by increasing immunomodulatory cytokines. We provided fresh molecular clues concerning the antiproliferative effect of CIGB-300 in two relevant AML backgrounds