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<p>Supplemental material, JOP780713_Supplementary_Figures for High dose psilocybin is associated with positive subjective effects in healthy volunteers by Christopher R Nicholas, Kelsey M Henriquez, Michele C Gassman, Karen M Cooper, Daniel Muller, Scott Hetzel, Randall T Brown, Nicholas V Cozzi, Chantelle Thomas and Paul R Hutson in Journal of Psychopharmacology</p

Additional file 6: of 1-Aminocyclopropane-1-carboxylate deaminase producers associated to maize and other Poaceae species

Figure S5. Pairwise comparison of plant phylogenetic distance between Poaceae (X-axis) with the corresponding Euclidean distance between acdS reads for each of the 20 most abundant microbial genera representing over 90% of acdS functional group diversity (Y-axis). The 18 maize-based comparisons are indicated using black triangles (maize-maize; n = 6), diamonds (maize-teosinte; n = 4), circles (maize-sorghum; n = 4), or squares (maize-wheat; n = 4), and the three other comparisons using a white circle (teosinte-sorghum), white triangle (teosinte-wheat) or white square (sorghum-wheat). Distances were calculated two by two, using Kimura two-parameter model for plant phylogeny and Euclidean distance for taxa. (TIF 155 kb

Additional file 7: of 1-Aminocyclopropane-1-carboxylate deaminase producers associated to maize and other Poaceae species

Figure S6. Root (A), rhizosphere soil (B), and shoot (C) dry weights. Statistical analyses were performed independently at 21 days in cropped soil, at 21 days in meadow soil, and at 42 days in cropped soil, using ANOVA and Fisher LSD tests (P < 0.05; differences shown with letters a to d). For maize lines FV4, W85, tomato, and bulk soil, two-way ANOVA and Fisher LSD tests (P < 0.05) were also performed to compare treatments according to past soil management or sampling time, and differences with the same genotype at 21 days in cropped soil are indicated by symbols * and #, respectively. (PDF 115 kb

Additional file 2: of 1-Aminocyclopropane-1-carboxylate deaminase producers associated to maize and other Poaceae species

Figure S1. Examples of PCR amplification with the different primer pairs tested. (A) acdsF5/acdsR7; (B) acdsF5/acdsR8; (C) acdsF6/acdsR7; (D) acdsF6/acdsR8; (E) acdsF8/acdsR10. The different strains tested were 1. Azospirillum lipoferum 4B; 2. A. lipoferum TVV3; 3. A lipoferum CRT1 (acdS-); 4. A. lipoferum RSWT1; 5. Burkholderia cepacia LMG1222; 6. B. cenocepacia LMG16656; 7. B. stabilis LMG14294; 8. B. dolosa LMG18941; 9. Pseudomonas thivervalensis PITR2; 10. P. kilonensis F113; 11. P. protegens CHA0 (acdS-); and 12. Ralstonia solanacearum GMI1000. (TIFF 13453 kb

qPCR

Quantification of Burkholderia cepacia complex in rhizosphere soil of the four maize lines

table probes

Normalized data of microarray. First colum correspond to maize rhizosphere or bulk soil samples, followed by the repetition number. the other columns are the results for each probes with positive hybridization after normalization. Probes are listed in Kyselkova et al. 2009 for more informations

Meditation or exercise for preventing acute respiratory infection (MEPARI-2): A randomized controlled trial

<div><p>Background</p><p>Practice of meditation or exercise may enhance health to protect against acute infectious illness.</p><p>Objective</p><p>To assess preventive effects of meditation and exercise on acute respiratory infection (ARI) illness.</p><p>Design</p><p>Randomized controlled prevention trial with three parallel groups.</p><p>Setting</p><p>Madison, Wisconsin, USA.</p><p>Participants</p><p>Community-recruited adults who did not regularly exercise or meditate.</p><p>Methods</p><p>1) 8-week behavioral training in mindfulness-based stress reduction (MBSR); 2) matched 8-week training in moderate intensity sustained exercise (EX); or 3) observational waitlist control. Training classes occurred in September and October, with weekly ARI surveillance through May. Incidence, duration, and area-under-curve ARI global severity were measured using daily reports on the WURSS-24 during ARI illness. Viruses were identified multiplex PCR. Absenteeism, health care utilization, and psychosocial health self-report assessments were also employed.</p><p>Results</p><p>Of 413 participants randomized, 390 completed the trial. In the MBSR group, 74 experienced 112 ARI episodes with 1045 days of ARI illness. Among exercisers, 84 had 120 episodes totaling 1010 illness days. Eighty-two of the controls had 134 episodes with 1210 days of ARI illness. Mean global severity was 315 for MBSR (95% confidence interval 244, 386), 256 (193, 318) for EX, and 336 (268, 403) for controls. A prespecified multivariate zero-inflated regression model suggested reduced incidence for MBSR (p = 0.036) and lower global severity for EX (p = 0.042), compared to control, not quite attaining the p<0.025 prespecified cut-off for null hypothesis rejection. There were 73 ARI-related missed-work days and 22 ARI-related health care visits in the MBSR group, 82 days and 21 visits for exercisers, and 105 days and 24 visits among controls. Viruses were identified in 63 ARI episodes in the MBSR group, compared to 64 for EX and 72 for control. Statistically significant (p<0.05) improvements in general mental health, self-efficacy, mindful attention, sleep quality, perceived stress, and depressive symptoms were observed in the MBSR and/or EX groups, compared to control.</p><p>Conclusions</p><p>Training in mindfulness meditation or exercise may help protect against ARI illness.</p><p>Limitations</p><p>This trial was likely underpowered.</p><p>Trial registration</p><p>Clinicaltrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT01654289" target="_blank">NCT01654289</a></p></div

Main ARI-related outcomes.

<p>Main ARI-related outcomes.</p

ARI = acute respiratory infection; Global severity = Area under time severity curve, calculated as trapezoidal approximation using daily scores on Wisconsin Upper Respiratory Infection Symptom Severity (WURSS-24) for y-axis and duration of ARI illness as x-axis; Error lines indicate 95% confidence intervals.

<p>ARI = acute respiratory infection; Global severity = Area under time severity curve, calculated as trapezoidal approximation using daily scores on Wisconsin Upper Respiratory Infection Symptom Severity (WURSS-24) for y-axis and duration of ARI illness as x-axis; Error lines indicate 95% confidence intervals.</p

Demographic and psychosocial characteristics of study population.

<p>Demographic and psychosocial characteristics of study population.</p