High Speed Chaos in Optical Feedback System with Flexible Timescales

We describe a new opto-electronic device with time-delayed feedback that uses a Mach-Zehnder interferometer as passive nonlinearity and a semiconductor laser as a current-to-optical-frequency converter. Bandlimited feedback allows tuning of the characteristic time scales of both the periodic and high dimensional chaotic oscillations that can be generated with the device. Our implementation of the device produces oscillations in the frequency range of tens to hundreds of MHz. We develop a model and use it to explore the experimentally observed Andronov-Hopf bifurcation of the steady state and to estimate the dimension of the chaotic attractor.Comment: 7 pages, 6 figures, to be published in IEEE J. Quantum Electro

Matching bias in syllogistic reasoning: Evidence for a dual-process account from response times and confidence ratings

We examined matching bias in syllogistic reasoning by analysing response times, confidence ratings, and individual differences. Roberts’ (2005) “negations paradigm” was used to generate conflict between the surface features of problems and the logical status of conclusions. The experiment replicated matching bias effects in conclusion evaluation (Stupple & Waterhouse, 2009), revealing increased processing times for matching/logic “conflict problems”. Results paralleled chronometric evidence from the belief bias paradigm indicating that logic/belief conflict problems take longer to process than non-conflict problems (Stupple, Ball, Evans, & Kamal-Smith, 2011). Individuals’ response times for conflict problems also showed patterns of association with the degree of overall normative responding. Acceptance rates, response times, metacognitive confidence judgements, and individual differences all converged in supporting dual-process theory. This is noteworthy because dual-process predictions about heuristic/analytic conflict in syllogistic reasoning generalised from the belief bias paradigm to a situation where matching features of conclusions, rather than beliefs, were set in opposition to logic

Loss Compensation in Time-Dependent Elastic Metamaterials

Materials with properties that are modulated in time are known to display wave phenomena showing energy increasing with time, with the rate mediated by the modulation. Until now there has been no accounting for material dissipation, which clearly counteracts energy growth. This paper provides an exact expression for the amplitude of elastic or acoustic waves propagating in lossy materials with properties that are periodically modulated in time. It is found that these materials can support a special propagation regime in which waves travel at constant amplitude, with temporal modulation compensating for the normal energy dissipation. We derive a general condition under which amplification due to time-dependent properties offsets the material dissipation. This identity relates band-gap properties associated with the temporal modulation and the average of the viscosity coefficient, thereby providing a simple recipe for the design of loss-compensated mechanical metamaterials

Joint perception: gaze and beliefs about social context

The way that we look at images is influenced by social context. Previously we demonstrated this phenomenon of joint perception. If lone participants believed that an unseen other person was also looking at the images they saw, it shifted the balance of their gaze between negative and positive images. The direction of this shift depended upon whether participants thought that later they would be compared against the other person or would be collaborating with them. Here we examined whether the joint perception is caused by beliefs about shared experience (looking at the same images) or beliefs about joint action (being engaged in the same task with the images). We place our results in the context of the emerging field of joint action, and discuss their connection to notions of group emotion and situated cognition. Such findings reveal the persuasive and subtle effect of social context upon cognitive and perceptual processes

Inhibitory control as a mediator of bidirectional effects between early oppositional behavior and maternal depression.

Maternal depression is an established risk factor for child conduct problems, but relatively few studies have tested whether children's behavioral problems exacerbate mothers' depression or whether other child behavioral characteristics (e.g., self-regulation) may mediate bidirectional effects between maternal depression and child disruptive behavior. This longitudinal study examined the parallel growth of maternal depressive symptoms and child oppositional behavior from ages 2 to 5; the magnitude and timing of their bidirectional effects; and whether child inhibitory control, a temperament-based self-regulatory mechanism, mediated effects between maternal depression and child oppositionality. A randomized control trial of 731 at-risk families assessed children annually from ages 2 to 5. Transactional models demonstrated positive and bidirectional associations between mothers' depressive symptoms and children's oppositional behavior from ages 2 to 3, with a less consistent pattern of reciprocal relations up to age 5. Mediation of indirect mother-child effects and child evocative effects depended on the rater of children's inhibitory control. Findings are discussed in regard to how child evocative effects and self-regulatory mechanisms may clarify the transmission of psychopathology within families

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation.

Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor receptor1 (FGFR1) (BCR-FGFR1) fusion protein. This fusion occurs in stem cell leukemia/lymphoma, which can progress to atypical chronic myeloid leukemia, acute myeloid leukemia, or B-cell lymphoma. This work focuses on the biochemical characterization of BCR-FGFR1 and identification of novel therapeutic targets. The tyrosine kinase activity of FGFR1 is required for biological activity as shown using transformation assays, interleukin-3 independent cell proliferation, and liquid chromatography/mass spectroscopy analyses. Furthermore, BCR contributes a coiled-coil oligomerization domain, also essential for oncogenic transformation by BCR-FGFR1. The importance of salt bridge formation within the coiled-coil domain is demonstrated, as disruption of three salt bridges abrogates cellular transforming ability. Lastly, BCR-FGFR1 acts as a client of the chaperonin heat shock protein 90 (Hsp90), suggesting that BCR-FGFR1 relies on Hsp90 complex to evade proteasomal degradation. Transformed cells expressing BCR-FGFR1 are sensitive to the Hsp90 inhibitor Ganetespib, and also respond to combined treatment with Ganetespib plus the FGFR inhibitor BGJ398. Collectively, these data suggest novel therapeutic approaches for future stem cell leukemia/lymphoma treatment: inhibition of BCR oligomerization by disruption of required salt bridges; and inhibition of the chaperonin Hsp90 complex