ROSAT and ASCA observations of the Crab-Like Supernova Remnant N157B in the Large Magellanic Cloud

We report the results of ROSAT and ASCA X-ray observations of the supernova remnant N157B (or 30 Dor B, SNR 0539-69.1) in the Large Magellanic Cloud. For comparison, we also briefly describe the results on SNR 0540-69.3, the only confirmed Crab-like remnant in the Cloud. The X-ray emission from N157B can be decomposed into a bright comet-shaped feature, superimposed on a diffuse emission region of a dimension $\sim 20$ pc. The flat and nearly featureless spectrum of the remnant is distinctly different from those of young shell-like remnants, suggesting a predominantly Crab-like nature of N157B. Characterized by a power law with an energy slope $\sim 1.5$, the spectrum of N157B above $\sim 2$ keV is, however, considerably steeper than that of SNR 0540-69.3, which has a slope of $\sim 1.0$. At lower energies, the spectrum of N157B presents marginal evidence for emission lines, which if real most likely arise in hot gas of the diffuse emission region. The hot gas has a characteristic thermal temperature of 0.4-0.7 keV. No significant periodic signal is detected from N157B in the period range of $3 \times 10^{-3}-2000$ s. The pulsed fraction is $\lesssim 9$ (99% confidence) in the $2-7$ keV range. We discuss the nature of the individual X-ray components. In particular, we suggest that the synchrotron radiation of relativistic particles from a fast-moving ($\sim 10^3 km s^{-1}$) pulsar explains the size, morphology, spectrum, and energetics of the comet-shaped X-ray feature. We infer the age of the remnant as $\sim 5 \times 10^3$ yrs. The lack of radio polarization of the remnant may be due to Faraday dispersion by foreground \ion{H}{2} gas.Comment: To be published in The Astrophysical Journal, 21 pages, plus 11 images in the PS, GIF, or jpeg format. Postscript files of images are available at http://www.astro.nwu.edu/astro/wqd/paper/n157b

Use of Shared Faculty in U.S. and Canadian Dental Schools

Dental schools are facing substantial financial challenges and a shortage of faculty members. One solution to address these issues has been to hire “shared” faculty members, i.e., faculty members whose primary appointment is at one institution who are hired by another institution to teach a course or part of a course. This is a controversial concept. A survey of academic deans at U.S. and Canadian dental schools was conducted for this study; thirty-nine (54 percent) of the seventy-two academic deans completed the online survey. This survey found that the use of shared faculty members is not rare amongst U.S. and Canadian dental schools and that the opinions of the academic deans about the use of shared faculty members ranged widely—from strong support to strong disapproval. Using shared faculty members has advantages and disadvantages for students, the shared faculty members, and both institutions. Many of the disadvantages could be potentially minimized by stakeholders’ working together to develop collaborative arrangements. Networks could be developed in which institutions coordinate hiring of shared faculty members based on what expertise is needed. Financial challenges and shortages of faculty members are unlikely to be resolved in the near future, but use of shared faculty members is one promising approach to begin to meet these challenges

Chloride channels regulate differentiation and barrier functions of the mammalian airway.

The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction leads to early onset airway diseases, remain unclear. In this study, we systematically characterized the developmental landscape of the mouse airway using single-cell RNA sequencing and identified remarkably conserved cellular programs operating during human fetal development. We demonstrated that in mouse, genetic inactivation of chloride channel Ano1/Tmem16a compromises airway barrier function, results in early signs of inflammation, and alters the airway cellular landscape by depleting epithelial progenitors. Mouse Ano1-/-mutants exhibited mucus obstruction and abnormal mucociliary clearance that resemble the airway defects associated with cystic fibrosis. The data reveal critical and non-redundant roles for Ano1 in organogenesis, and show that chloride channels are essential for mammalian airway formation and function

The Relationship Between Self-Reported History of Endodontic Therapy and Coronary Heart Disease in the Atherosclerosis Risk in Communities Study

Results from numerous studies have suggested links between periodontal disease and coronary heart disease (CHD), but endodontic disease has not been studied extensively in this regard

The Incidence of Highly-Obscured Star-Forming Regions in SINGS Galaxies

Using the new capabilities of the Spitzer Space Telescope and extensive multiwavelength data from the Spitzer Infrared Nearby Galaxies Survey (SINGS), it is now possible to study the infrared properties of star formation in nearby galaxies down to scales equivalent to large HII regions. We are therefore able to determine what fraction of large, infrared-selected star-forming regions in normal galaxies are highly obscured and address how much of the star formation we miss by relying solely on the optical portion of the spectrum. Employing a new empirical method for deriving attenuations of infrared-selected star-forming regions we investigate the statistics of obscured star formation on 500pc scales in a sample of 38 nearby galaxies. We find that the median attenuation is 1.4 magnitudes in H-alpha and that there is no evidence for a substantial sub-population of uniformly highly-obscured star-forming regions. The regions in the highly-obscured tail of the attenuation distribution (A_H-alpha > 3) make up only ~4% of the sample of nearly 1800 regions, though very embedded infrared sources on the much smaller scales and lower luminosities of compact and ultracompact HII regions are almost certainly present in greater numbers. The highly-obscured cases in our sample are generally the bright, central regions of galaxies with high overall attenuation but are not otherwise remarkable. We also find that a majority of the galaxies show decreasing radial trends in H-alpha attenuation. The small fraction of highly-obscured regions seen in this sample of normal, star-forming galaxies suggests that on 500pc scales the timescale for significant dispersal or break up of nearby, optically-thick dust clouds is short relative to the lifetime of a typical star-forming region.Comment: Accepted for publication in ApJ; emulateapj style, 30 pages, 18 figures (compressed versions), 3 table

The Nature of Infrared Emission in the Local Group Dwarf Galaxy NGC 6822 As Revealed by Spitzer

We present Spitzer imaging of the metal-deficient (Z ~30% Z_sun) Local Group dwarf galaxy NGC 6822. On spatial scales of ~130 pc, we study the nature of IR, H alpha, HI, and radio continuum emission. Nebular emission strength correlates with IR surface brightness; however, roughly half of the IR emission is associated with diffuse regions not luminous at H alpha (as found in previous studies). The global ratio of dust to HI gas in the ISM, while uncertain at the factor of ~2 level, is ~25 times lower than the global values derived for spiral galaxies using similar modeling techniques; localized ratios of dust to HI gas are about a factor of five higher than the global value in NGC 6822. There are strong variations (factors of ~10) in the relative ratios of H alpha and IR flux throughout the central disk; the low dust content of NGC 6822 is likely responsible for the different H alpha/IR ratios compared to those found in more metal-rich environments. The H alpha and IR emission is associated with high-column density (> ~1E21 cm^-2) neutral gas. Increases in IR surface brightness appear to be affected by both increased radiation field strength and increased local gas density. Individual regions and the galaxy as a whole fall within the observed scatter of recent high-resolution studies of the radio-far IR correlation in nearby spiral galaxies; this is likely the result of depleted radio and far-IR emission strengths in the ISM of this dwarf galaxy.Comment: ApJ, in press; please retrieve full-resolution version from http://www.astro.wesleyan.edu/~cannon/pubs.htm

Association of Endodontic Involvement with Tooth Loss in the Veterans Affairs Dental Longitudinal Study

The effect of endodontic involvement on tooth loss has not been quantified, so the present study aimed to assess this relationship after controlling for other relevant risk factors for tooth loss

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

Background: T-cell tolerance of allergic cutaneous contact sensitivity (CS) induced in mice by high doses of reactive hapten is mediated by suppressor cells that release antigen-specific suppressive nanovesicles. Objective: We sought to determine the mechanism or mechanisms of immune suppression mediated by the nanovesicles. Methods: T-cell tolerance was induced by means of intravenous injection of hapten conjugated to self-antigens of syngeneic erythrocytes and subsequent contact immunization with the same hapten. Lymph node and spleen cells from tolerized or control donors were harvested and cultured to produce a supernatant containing suppressive nanovesicles that were isolated from the tolerized mice for testing in active and adoptive cell-transfer models of CS. Results: Tolerance was shown due to exosome-like nanovesicles in the supernatants of CD81 suppressor T cells that were not regulatory T cells. Antigen specificity of the suppressive nanovesicles was conferred by a surface coat of antibody light chains or possibly whole antibody, allowing targeted delivery of selected inhibitory microRNA (miRNA)–150 to CS effector T cells. Nanovesicles also inhibited CS in actively sensitized mice after systemic injection at the peak of the responses. The role of antibody and miRNA-150 was established by tolerizing either panimmunoglobulin-deficient JH2/2 or miRNA-1502/2 mice that produced nonsuppressive nanovesicles. These nanovesicles could be made suppressive by adding antigen-specific antibody light chains or miRNA-150, respectively. Conclusions: This is the first example of T-cell regulation through systemic transit of exosome-like nanovesicles delivering a chosen inhibitory miRNA to target effector T cells in an antigen-specific manner by a surface coating of antibody light chains

Spitzer and JCMT Observations of the Active Galactic Nucleus in the Sombrero Galaxy (NGC 4594)

We present Spitzer 3.6-160 micron images, Spitzer mid-infrared spectra, and JCMT SCUBA 850 micron images of the Sombrero Galaxy (NGC 4594), an Sa galaxy with a 10^9 M_solar low luminosity active galactic nucleus (AGN). The brightest infrared sources in the galaxy are the nucleus and the dust ring. The spectral energy distribution of the AGN demonstrates that, while the environment around the AGN is a prominent source of mid-infrared emission, it is a relatively weak source of far-infrared emission, as had been inferred for AGN in previous research. The weak nuclear 160 micron emission and the negligible polycyclic aromatic hydrocarbon emission from the nucleus also implies that the nucleus is a site of only weak star formation activity and the nucleus contains relatively little cool interstellar gas needed to fuel such activity. We propose that this galaxy may be representative of a subset of low ionization nuclear emission region galaxies that are in a quiescent AGN phase because of the lack of gas needed to fuel circumnuclear star formation and Seyfert-like AGN activity. Surprisingly, the AGN is the predominant source of 850 micron emission. We examine the possible emission mechanisms that could give rise to the 850 micron emission and find that neither thermal dust emission, CO line emission, bremsstrahlung emission, nor the synchrotron emission observed at radio wavelengths can adequately explain the measured 850 micron flux density by themselves. The remaining possibilities for the source of the 850 micron emission include a combination of known emission mechanisms, synchrotron emission that is self-absorbed at wavelengths longer than 850 microns, or unidentified spectral lines in the 850 micron band.Comment: Accepted to ApJ, 200

Advancing specificity in delirium: The delirium subtyping initiative

BACKGROUND: Delirium, a common syndrome with heterogeneous etiologies and clinical presentations, is associated with poor long-term outcomes. Recording and analyzing all delirium equally could be hindering the field's understanding of pathophysiology and identification of targeted treatments. Current delirium subtyping methods reflect clinically evident features but likely do not account for underlying biology. METHODS: The Delirium Subtyping Initiative (DSI) held three sessions with an international panel of 25 experts. RESULTS: Meeting participants suggest further characterization of delirium features to complement the existing Diagnostic and Statistical Manual of Mental Disorders Fifth Edition Text Revision diagnostic criteria. These should span the range of delirium-spectrum syndromes and be measured consistently across studies. Clinical features should be recorded in conjunction with biospecimen collection, where feasible, in a standardized way, to determine temporal associations of biology coincident with clinical fluctuations. DISCUSSION: The DSI made recommendations spanning the breadth of delirium research including clinical features, study planning, data collection, and data analysis for characterization of candidate delirium subtypes. HIGHLIGHTS: Delirium features must be clearly defined, standardized, and operationalized. Large datasets incorporating both clinical and biomarker variables should be analyzed together. Delirium screening should incorporate communication and reasoning