Understanding Leadership in Small Business from the Perspectives of Practitioners

Many small businesses fail after 5 years, having a negative impact on local and national economies. The purpose of this phenomenological study was to explore small-enterprise leader-operators’ experiences regarding practices that aid sustainability beyond 5 years. Twenty small enterprise leaders in the United States Midwest who were identified as having 5 years of longevity in leading organizations with fewer than 500 employees were invited to participate. These participants shared their lived experiences through semistructured interviews conducted in-person and by telephone. The dynamic theory of leadership development was used to underpin the study. In the central research question for this study, the skills and practices needed by small-business practitioners to ensure success beyond 5 years were addressed. A reduction method was used to reduce data from 11 interview questions in 20 semistructured interviews into common themes. Seven themes emerged as long-term practices used by practitioners. These 7 practices included collaboration and forms of communication, mentoring, people skills, networking, investing in people, setting an example, and planning. The implications for positive social change include the potential to stabilize the economic wellbeing of the small business sector and therefore the community. Small business practitioners may benefit from this research by identifying and improving practices leading to long-term viability

Nicotine Directly Induces Endoplasmic Reticulum Stress Response in Rat Placental Trophoblast Giant Cells

Nicotine exposure during pregnancy leads to placental insufficiency impairing both fetal and neonatal development. Previous studies from our laboratory have demonstrated that in rats,nicotine augmented endoplasmic reticulum (ER) stress in association with placental insufficiency, however, the underlying mechanisms remain elusive. Therefore, we sought to investigate the possible direct effect of nicotine on ER stress in Rcho-1 rat placental trophoblastgiant (TG) cells during differentiation. Protein and/or mRNA expression of markers involved in ER stress (e.g., phosphorylated PERK, eIF2α, CHOP, BiP/GRP78) and trophoblast giant cell differentiation and function (e.g., Pl-1, Pgf, Hsd11b1, and Hsd11b2) were quantified via Western blot or Real-Time PCR. Nicotine treatment led to dose-dependent increases in the phosphorylation of PERK[Thr981] and eIF2α[Ser51], whereas pre-treatment with a nicotinic acetylcholine receptor (nAChR) antagonist (mecamylamine hydrochloride) blocked the induction of PERK phosphorylation, verifying the direct involvement of nicotine and nAChR binding. We next investigated select target genes known to play essential roles in placental TG cell differentiation and function (Pl-1, Pgf, Hsd11b1, and Hsd11b2), and found that nicotine significantly augmented the mRNA levels of Hsd11b1 in a dose-dependent manner. Furthermore, using Tauroursodeoxycholic acid (TUDCA), a safe bile acid known to improve protein chaperoning and folding, we were able to prevent nicotine-induced increases in both PERK phosphorylation and Hsd11b1 mRNA levels, revealing a potential novel therapeutic approach to reverse the deleterious effects of nicotine exposure in pregnancy. Collectively, these results implicate that nicotine, acting through its receptor, can directly augment ER stress and impair placental function

“Funerals aren’t nice but it couldn’t have been nicer”. The makings of a good funeral

There is growing comment in both academic and popular writing about the shape and content of funerals today, with general agreement that we are seeing marked changes with a growing trend towards secularisation and personalisation. Despite this, there is as yet relatively little systematic research on the topic. This article reports on a study funded by the Arts and Humanities Research Council UK into spirituality in contemporary funerals. This qualitative study centred around case studies of 46 funerals in the north of England and gathered data from observations of funeral arrangement meetings as well as the funeral and semi-structured interviews with bereaved families and funeral professionals. The way both sets of participants engaged with the funeral and its constituent elements in an active process of meaning-seeking, meaning-creating and meaning-taking was closely aligned with contemporary understandings of humanistic spirituality. There was, however, little evidence of adherence to formal religious belief systems or wider philosophical frameworks amongst the bereaved families but considerable evidence of drawing on religious tradition and specific beliefs to locate personal meaning-making. The authors conclude that the funeral remains a significant ceremonial event which is psycho-social-spiritual in character and purpose

Maternal Nicotine Exposure Leads to Augmented Expression of the Antioxidant Adipose Tissue Triglyceride Lipase Long-Term in the White Adipose of Female Rat Offspring.

Globally, approximately 10-25% of women smoke during pregnancy. Since nicotine is highly addictive, women may use nicotine containing products like nicotine replacement therapies for smoking cessation, but the long-term consequences of early life exposure to nicotine remain poorly defined. Our laboratory has previously demonstrated that maternal nicotine exposed (MNE) rat offspring exhibit hypertriglyceridemia due to increased hepatic de novo lipogenesis. Hypertriglyceridemia may also be attributed to impaired white adipose tissue (WAT) lipid storage; however, the effects of MNE on WAT are not completely understood. We hypothesize that nicotine-induced alterations in adipose function (e.g. lipid storage) underlie dyslipidemia in MNE adults. Female 6 month old rats exposed to nicotine during gestation and lactation exhibited significantly decreased visceral adipocyte cell area by 40%, attributed, in part, to a 3-fold increase in adipose triglyceride lipase (ATGL) protein expression compared to vehicle. Given ATGL has antioxidant properties and in utero nicotine exposure promotes oxidative stress in various tissues, we next investigated if there was evidence of increased oxidative stress in MNE WAT. At both 3 weeks and 6 months, MNE offspring expressed 37-48% higher protein levels of SOD1 and SOD2 in WAT. Since oxidative stress can induce inflammation, we examined the inflammatory profile of WAT and found increased expression of cytokines (IL-1β, TNFα, and IL-6) by 44-61% at 6 months. Collectively, this suggests that the expression of WAT ATGL may be induced to counter MNE-induced oxidative stress and inflammation. However, higher levels of ATGL would further promote lipolysis in WAT, culminating in impaired lipid storage and long-term dyslipidemia

An Ultra-Low Resource Ion Mass Spectrometer for CubeSat Platforms

The Compact Ion Mass Spectrometer (CIMS) is a highly compact ion mass spectrometer capable of mass resolution for low-energy space plasma. CIMS is capable of measuring flux, energy, and mass of ions providing unique measurements of the ionospheric outflow and cold plasma in the magnetosphere. The CIMS utilizes a laminated collimator to define the field-of-view, a laminated electrostatic analyzer to selectively filter ions based on energy-per- charge, a magnetic sector analyzer to separate ions by mass-per-charge, and a microchannel plate with a position sensitive cross-delay anode assembly to detect the location of the ions on the detector plane. This ion mass spectrometer is a simple, compact, and robust instrument ideal for obtaining low-energy (0.1 eV to 1000 eV) ion composition measurements of ionospheric and cold magnetospheric space plasma. The instrument design has significant mass and volume savings when compared to current state-of-the-art ion mass spectrometers and has the additional advantage of being able to simultaneously measure multiple ion species signals of a given energy at 100% duty cycle, thus providing a true mass spectrum. The extremely low resource requirements of the CIMS instrument in combination with the relaxed fabrication techniques and ease of assembly allows for rapid and low-cost production

Social interaction and gamification with youth at risk of social exclusion: The technological approach of the Keystone project

This paper presents the Keystone project, which proposes a multidisciplinary approach to improve the opportunities of young people at risk of social exclusion. The focus of the paper is the technological approach built from the results of research using lifeworld analysis to identify the barriers and drivers to youth participation. This technological approach combines on the one hand, the KEY Tool, a simplified goal-oriented social network to share and interact with local and international peers; on the other hand, the KEY game, a false instant-messaging application based on a voodoo story, where the user has a key role. Several pilot groups worked under the programme implemented in the Keystone project, including working with those digital tools. Results show important benefits for participating young people in areas such as respect, digital literacy and multi-cultural abilities, and highlight several opportunities to take further advantage of these tools

Climate change: challenges and opportunities for global health.

IMPORTANCE: Health is inextricably linked to climate change. It is important for clinicians to understand this relationship in order to discuss associated health risks with their patients and to inform public policy. OBJECTIVES: To provide new US-based temperature projections from downscaled climate modeling and to review recent studies on health risks related to climate change and the cobenefits of efforts to mitigate greenhouse gas emissions. DATA SOURCES, STUDY SELECTION, AND DATA SYNTHESIS: We searched PubMed and Google Scholar from 2009 to 2014 for articles related to climate change and health, focused on governmental reports, predictive models, and empirical epidemiological studies. Of the more than 250 abstracts reviewed, 56 articles were selected. In addition, we analyzed climate data averaged over 13 climate models and based future projections on downscaled probability distributions of the daily maximum temperature for 2046-2065. We also compared maximum daily 8-hour average ozone with air temperature data taken from the National Oceanic and Atmospheric Administration, National Climate Data Center. RESULTS: By 2050, many US cities may experience more frequent extreme heat days. For example, New York and Milwaukee may have 3 times their current average number of days hotter than 32°C (90°F). High temperatures are also strongly associated with ozone exceedance days, for example, in Chicago, Illinois. The adverse health aspects related to climate change may include heat-related disorders, such as heat stress and economic consequences of reduced work capacity; respiratory disorders, including those exacerbated by air pollution and aeroallergens, such as asthma; infectious diseases, including vectorborne diseases and waterborne diseases, such as childhood gastrointestinal diseases; food insecurity, including reduced crop yields and an increase in plant diseases; and mental health disorders, such as posttraumatic stress disorder and depression, that are associated with natural disasters. Substantial health and economic cobenefits could be associated with reductions in fossil fuel combustion. For example, greenhouse gas emission policies may yield net economic benefit, with health benefits from air quality improvements potentially offsetting the cost of US and international carbon policies. CONCLUSIONS AND RELEVANCE: Evidence over the past 20 years indicates that climate change can be associated with adverse health outcomes. Health care professionals have an important role in understanding and communicating the related potential health concerns and the cobenefits from policies to reduce greenhouse gas emissions