46 research outputs found
Geometry of River Networks II: Distributions of Component Size and Number
The structure of a river network may be seen as a discrete set of nested
sub-networks built out of individual stream segments. These network components
are assigned an integral stream order via a hierarchical and discrete ordering
method. Exponential relationships, known as Horton's laws, between stream order
and ensemble-averaged quantities pertaining to network components are observed.
We extend these observations to incorporate fluctuations and all higher moments
by developing functional relationships between distributions. The relationships
determined are drawn from a combination of theoretical analysis, analysis of
real river networks including the Mississippi, Amazon and Nile, and numerical
simulations on a model of directed, random networks. Underlying distributions
of stream segment lengths are identified as exponential. Combinations of these
distributions form single-humped distributions with exponential tails, the sums
of which are in turn shown to give power law distributions of stream lengths.
Distributions of basin area and stream segment frequency are also addressed.
The calculations identify a single length-scale as a measure of size
fluctuations in network components. This article is the second in a series of
three addressing the geometry of river networks.Comment: 16 pages, 13 figures, 4 tables, Revtex4, submitted to PR
Analyzing the impact of course structure on electronic textbook use in blended introductory physics courses
We investigate how elements of course structure (i.e., the frequency of assessments as well as the sequencing and weight of course resources) influence the usage patterns of electronic textbooks (e-texts) in introductory physics courses. Specifically, we analyze the access logs of courses at Michigan State University and the Massachusetts Institute of Technology, each of which deploy e-texts as primary or secondary texts in combination with different formative assessments (e.g., embedded reading questions) and different summative assessment (exam) schedules. As such studies are frequently marred by arguments over what constitutes a “meaningful” interaction with a particular page (usually judged by how long the page remains on the screen), we consider a set of different definitions of “meaningful” interactions. We find that course structure has a strong influence on how much of the e-texts students actually read, and when they do so. In particular, courses that deviate strongly from traditional structures, most notably by more frequent exams, show consistently high usage of the materials with far less “cramming” before exams.National Science Foundation (U.S.) (Grant DUE-1044294)Google (Firm
Analyzing the impact of course structure on electronic textbook use in blended introductory physics courses
We investigate how elements of course structure (i.e., the frequency of assessments as well as the sequencing and weight of course resources) influence the usage patterns of electronic textbooks (e-texts) in introductory physics courses. Specifically, we analyze the access logs of courses at Michigan State University and the Massachusetts Institute of Technology, each of which deploy e-texts as primary or secondary texts in combination with different formative assessments (e.g., embedded reading questions) and different summative assessment (exam) schedules. As such studies are frequently marred by arguments over what constitutes a “meaningful” interaction with a particular page (usually judged by how long the page remains on the screen), we consider a set of different definitions of “meaningful” interactions. We find that course structure has a strong influence on how much of the e-texts students actually read, and when they do so. In particular, courses that deviate strongly from traditional structures, most notably by more frequent exams, show consistently high usage of the materials with far less “cramming” before exams.National Science Foundation (U.S.) (Grant DUE-1044294)Google (Firm
CORONA (COre ultRasOund of covid in iNtensive care & Acute medicine) Study : national service evaluation of lung and heart ultrasound in intensive care patients with suspected or proven COVID-19
Background
Combined Lung Ultrasound (LUS) and Focused UltraSound for Intensive Care heart (FUSIC Heart - formerly Focused Intensive Care Echocardiography, FICE) can aid diagnosis, risk stratification and management in COVID-19. However, data on its application and results are limited to small studies in varying countries and hospitals. This United Kingdom (UK) national service evaluation study assessed how combined LUS and FUSIC Heart were used in COVID-19 Intensive Care Unit (ICU) patients during the first wave of the pandemic.
Method
Twelve trusts across the UK registered for this prospective study. LUS and FUSIC Heart data were obtained, using a standardised data set including scoring of abnormalities, between 1st February 2020 to 30th July 2020. The scans were performed by intensivists with FUSIC Lung and Heart competency as a minimum standard. Data was anonymised locally prior to transfer to a central database.
Results
372 studies were performed on 265 patients. There was a small but significant relationship between LUS score >8 and 30-day mortality (OR 1.8). Progression of score was associated with an increase in 30-day mortality (OR 1.2). 30-day mortality was increased in patients with right ventricular (RV) dysfunction (49.4% vs 29.2%). Severity of LUS score correlated with RV dysfunction (p < 0.05). Change in management occurred in 65% of patients following a combined scan.
Conclusions
In COVID-19 patients, there is an association between lung ultrasound score severity, RV dysfunction and mortality identifiable by combined LUS and FUSIC Heart. The use of 12-point LUS scanning resulted in similar risk score to 6-point imaging in the majority of cases. Our findings suggest that serial combined LUS and FUSIC Heart on COVID-19 ICU patients may aid in clinical decision making and prognostication
Concurrent pulmonary zygomycosis and Mycobacterium tuberculosis infection: a case report
A non-smoking 77-year old gentleman of Indian origin was admitted with a 4-month history of intermittent night sweats, haemoptysis and 6 kg of weight loss. CT scan of thorax demonstrated a 2.5 cm mass in the right middle lobe with multiple small nodules within the right lung and confirmed the presence of mediastinal and hilar lymph nodes
Unified View of Scaling Laws for River Networks
Scaling laws that describe the structure of river networks are shown to
follow from three simple assumptions. These assumptions are: (1) river networks
are structurally self-similar, (2) single channels are self-affine, and (3)
overland flow into channels occurs over a characteristic distance (drainage
density is uniform). We obtain a complete set of scaling relations connecting
the exponents of these scaling laws and find that only two of these exponents
are independent. We further demonstrate that the two predominant descriptions
of network structure (Tokunaga's law and Horton's laws) are equivalent in the
case of landscapes with uniform drainage density. The results are tested with
data from both real landscapes and a special class of random networks.Comment: 14 pages, 9 figures, 4 tables (converted to Revtex4, PRE ref added
Geometry of River Networks I: Scaling, Fluctuations, and Deviations
This article is the first in a series of three papers investigating the
detailed geometry of river networks. Large-scale river networks mark an
important class of two-dimensional branching networks, being not only of
intrinsic interest but also a pervasive natural phenomenon. In the description
of river network structure, scaling laws are uniformly observed. Reported
values of scaling exponents vary suggesting that no unique set of scaling
exponents exists. To improve this current understanding of scaling in river
networks and to provide a fuller description of branching network structure, we
report here a theoretical and empirical study of fluctuations about and
deviations from scaling. We examine data for continent-scale river networks
such as the Mississippi and the Amazon and draw inspiration from a simple model
of directed, random networks. We center our investigations on the scaling of
the length of sub-basin's dominant stream with its area, a characterization of
basin shape known as Hack's law. We generalize this relationship to a joint
probability density and show that fluctuations about scaling are substantial.
We find strong deviations from scaling at small scales which can be explained
by the existence of linear network structure. At intermediate scales, we find
slow drifts in exponent values indicating that scaling is only approximately
obeyed and that universality remains indeterminate. At large scales, we observe
a breakdown in scaling due to decreasing sample space and correlations with
overall basin shape. The extent of approximate scaling is significantly
restricted by these deviations and will not be improved by increases in network
resolution.Comment: 16 pages, 13 figures, Revtex4, submitted to PR
The Making of a Productivity Hotspot in the Coastal Ocean
Highly productive hotspots in the ocean often occur where complex physical forcing mechanisms lead to aggregation of primary and secondary producers. Understanding how hotspots persist, however, requires combining knowledge of the spatio-temporal linkages between geomorphology, physical forcing, and biological responses with the physiological requirements and movement of top predators.) off the Baja California peninsula, Mexico.We have identified the set of conditions that lead to a persistent top predator hotspot, which increases our understanding of how highly migratory species exploit productive regions of the ocean. These results will aid in the development of spatially and environmentally explicit management strategies for marine species of conservation concern
A treatment evaluator tool to monitor the real-world effectiveness of inhaled aztreonam lysine in cystic fibrosis
Background: Studies are required that evaluate real-world outcomes of inhaled aztreonam lysine in patients with cystic fibrosis (CF). Methods: Our treatment-evaluator tool assessed the effectiveness of inhaled aztreonam in routine practice in 117 CF patients across four time periods (6–12 (P2) and 0–6 months (P1) pre-initiation, and 0–6 (T1) and 6–12 months (T2) post-initiation). Outcomes were: changes in %-predicted forced expiratory volume in 1 s (FEV1), body-mass index (BMI), hospitalisation days and intravenous antibiotic usage. Results: Median FEV1% predicted for each 6-month period was 38.9%, 34.6%, 37.1% and 36.5%; median change was − 2.0% between P2 and P1, increasing to + 0.6% (p < 0.001) between P1 and T1. Annualised hospital bed-days was reduced (p = 0.05) post-initiation, as was intravenous antibiotics days (p = 0.001). BMI increased over 6 months post-initiation (p ≤ 0.001). Conclusions: In patients with CF in routine practice, inhaled aztreonam lysine is associated with improved lung function and weight, and reduced hospitalisation and intravenous antibiotic use
The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN
Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and limited evidence-based treatments. Management is mainly based on expert opinions and treatment is challenging due to a wide range of clinical manifestations and disease severity. To improve clinical and translational research and facilitate development of new treatments, the clinical trial network for PCD (PCD-CTN) was founded in 2020 under the framework of the European Reference Network (ERN)-LUNG PCD Core. Applications from European PCD sites interested in participating in the PCD-CTN were requested. Inclusion criteria consisted of patient numbers, membership of ERN-LUNG PCD Core, use of associated standards of care, experience in PCD and/or CF clinical research, resources to run clinical trials, good clinical practice (GCP) certifications and institutional support. So far, applications from 22 trial sites in 18 European countries have been approved, including >1400 adult and >1600 paediatric individuals with PCD. The PCD-CTN is headed by a coordinating centre and consists of a steering and executive committee, a data safety monitoring board and committees for protocol review, training and standardisation. A strong association with patient organisations and industrial companies are further cornerstones. All participating trial sites agreed on a code of conduct. As CTNs from other diseases have demonstrated successfully, this newly formed PCD-CTN operates to establish evidence-based treatments for this orphan disease and to bring new personalised treatment approaches to patients