3,119 research outputs found
Volatility spillover between New Zealand stock market returns and exchange rate changes before and after the 1997 Asian financial crisis
Researchers in the last decade have been investigating the interdependence of stock returns and exchange rate changes within the same economy. Kanas (2000) and Yang and Doong (2004) find that for the G-7 countries, in general, the volatility of the stock market spills over to the exchange rate market but that volatility spillovers from the exchange rate market to the stock market are insignificant. Chen, Naylor, and Lu (2004) find that NZ individual firm returns are significantly exposed to exchange rate changes. This study complements their work by investigating the volatility spillover between the stock market and the foreign exchange market within the NZ economy.<br /
The Panchromatic Hubble Andromeda Treasury XI: The Spatially-Resolved Recent Star Formation History of M31
We measure the recent star formation history (SFH) across M31 using optical
images taken with the \texit{Hubble Space Telescope} as part of the
Panchromatic Hubble Andromeda Treasury (PHAT). We fit the color-magnitude
diagrams in ~9000 regions that are ~100 pc 100 pc in projected size,
covering a 0.5 square degree area (~380 kpc, deprojected) in the NE
quadrant of M31. We show that the SFHs vary significantly on these small
spatial scales but that there are also coherent galaxy-wide fluctuations in the
SFH back to ~500 Myr, most notably in M31's 10-kpc star-forming ring. We find
that the 10-kpc ring is at least 400 Myr old, showing ongoing star formation
over the past ~500 Myr. This indicates the presence of molecular gas in the
ring over at least 2 dynamical times at this radius. We also find that the
ring's position is constant throughout this time, and is stationary at the
level of 1 km/s, although there is evidence for broadening of the ring due to
diffusion of stars into the disk. Based on existing models of M31's ring
features, the lack of evolution in the ring's position makes a purely
collisional ring origin highly unlikely. We find that the global SFR has been
fairly constant over the last ~500 Myr, though it does show a small increase at
50 Myr that is 1.3 times the average SFR over the past 100 Myr. During the last
~500 Myr, ~60% of all SF occurs in the 10-kpc ring. Finally, we find that in
the past 100 Myr, the average SFR over the PHAT survey area is
M yr with an average deprojected intensity of M yr kpc, which yields a total SFR of ~0.7
M yr when extrapolated to the entire area of M31's disk. This
SFR is consistent with measurements from broadband estimates. [abridged]Comment: 23 pages, 17 figures, 2 tables, accepted for publication in Ap
Clinical and Financial Outcomes Due to Methicillin Resistant Staphylococcus aureus Surgical Site Infection: A Multi-Center Matched Outcomes Study
The clinical and financial outcomes of SSIs directly attributable to MRSA and methicillin-resistance are largely uncharacterized. Previously published data have provided conflicting conclusions.We conducted a multi-center matched outcomes study of 659 surgical patients. Patients with SSI due to MRSA were compared with two groups: matched uninfected control patients and patients with SSI due to MSSA. Four outcomes were analyzed for the 90-day period following diagnosis of the SSI: mortality, readmission, duration of hospitalization, and hospital charges. Attributable outcomes were determined by logistic and linear regression.In total, 150 patients with SSI due to MRSA were compared to 231 uninfected controls and 128 patients with SSI due to MSSA. SSI due to MRSA was independently predictive of readmission within 90 days (OR = 35.0, 95% CI 17.3-70.7), death within 90 days (OR = 7.27, 95% CI 2.83-18.7), and led to 23 days (95% CI 19.7-26.3) of additional hospitalization and 24,113 (95% 4,521-43,704) of additional charges.The attributable impact of S. aureus and methicillin-resistance on outcomes of surgical patients is substantial. Preventing a single case of SSI due to MRSA can save hospitals as much as $60,000
Gravitino Dark Matter and Cosmological Constraints
The gravitino is a promising candidate for cold dark matter. We study
cosmological constraints on scenarios in which the gravitino is the lightest
supersymmetric particle and a charged slepton the next-to-lightest
supersymmetric particle (NLSP). We obtain new results for the hadronic
nucleosynthesis bounds by computing the 4-body decay of the NLSP slepton into
the gravitino, the associated lepton, and a quark-antiquark pair. The bounds
from the observed dark matter density are refined by taking into account
gravitinos from both late NLSP decays and thermal scattering in the early
Universe. We examine the present free-streaming velocity of gravitino dark
matter and the limits from observations and simulations of cosmic structures.
Assuming that the NLSP sleptons freeze out with a thermal abundance before
their decay, we derive new bounds on the slepton and gravitino masses. The
implications of the constraints for cosmology and collider phenomenology are
discussed and the potential insights from future experiments are outlined. We
propose a set of benchmark scenarios with gravitino dark matter and long-lived
charged NLSP sleptons and describe prospects for the Large Hadron Collider and
the International Linear Collider.Comment: 51 pages, 20 figures, revised version matches published version
(results unchanged, JHEP style used, figures replaced with new high-quality
figures, typos corrected, references added
Andreev-Tunneling, Coulomb Blockade, and Resonant Transport of Non-Local Spin-Entangled Electrons
We propose and analyze a spin-entangler for electrons based on an s-wave
superconductor coupled to two quantum dots each of which is tunnel-coupled to
normal Fermi leads. We show that in the presence of a voltage bias and in the
Coulomb blockade regime two correlated electrons provided by the Andreev
process can coherently tunnel from the superconductor via different dots into
different leads. The spin-singlet coming from the Cooper pair remains preserved
in this process, and the setup provides a source of mobile and nonlocal
spin-entangled electrons. The transport current is calculated and shown to be
dominated by a two-particle Breit-Wigner resonance which allows the injection
of two spin-entangled electrons into different leads at exactly the same
orbital energy, which is a crucial requirement for the detection of spin
entanglement via noise measurements. The coherent tunneling of both electrons
into the same lead is suppressed by the on-site Coulomb repulsion and/or the
superconducting gap, while the tunneling into different leads is suppressed
through the initial separation of the tunneling electrons. In the regime of
interest the particle-hole excitations of the leads are shown to be negligible.
The Aharonov-Bohm oscillations in the current are shown to contain single- and
two-electron periods with amplitudes that both vanish with increasing Coulomb
repulsion albeit differently fast.Comment: 11 double-column pages, 2 figures, REVTeX, minor revision
Recommended from our members
Gem1 and ERMES Do Not Directly Affect Phosphatidylserine Transport from ER to Mitochondria or Mitochondrial Inheritance
In yeast, a protein complex termed the ER-Mitochondria Encounter Structure (ERMES) tethers mitochondria to the endoplasmic reticulum. ERMES proteins are implicated in a variety of cellular functions including phospholipid synthesis, mitochondrial protein import, mitochondrial attachment to actin, polarized mitochondrial movement into daughter cells during division, and maintenance of mitochondrial DNA (mtDNA). The mitochondrial-anchored Gem1 GTPase has been proposed to regulate ERMES functions. Here, we show that ERMES and Gem1 have no direct role in the transport of phosphatidylserine (PS) from the ER to mitochondria during the synthesis of phosphatidylethanolamine (PE), as PS to PE conversion is not affected in ERMES or gem1 mutants. In addition, we report that mitochondrial inheritance defects in ERMES mutants are a secondary consequence of mitochondrial morphology defects, arguing against a primary role for ERMES in mitochondrial association with actin and mitochondrial movement. Finally, we show that ERMES complexes are long-lived, and do not depend on the presence of Gem1. Our findings suggest that the ERMES complex may have primarily a structural role in maintaining mitochondrial morphology
Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations
PURPOSE: Predicting the phenotypic effects of mutations has become an important application in clinical genetic diagnostics. Computational tools evaluate the behavior of the variant over evolutionary time and assume that variations seen during the course of evolution are probably benign in humans. However, current tools do not take into account orthologous/paralogous relationships. Paralogs have dramatically different roles in Mendelian diseases. For example, whereas inactivating mutations in the NPC1 gene cause the neurodegenerative disorder Niemann-Pick C, inactivating mutations in its paralog NPC1L1 are not disease-causing and, moreover, are implicated in protection from coronary heart disease. METHODS: We identified major events in NPC1 evolution and revealed and compared orthologs and paralogs of the human NPC1 gene through phylogenetic and protein sequence analyses. We predicted whether an amino acid substitution affects protein function by reducing the organismâs fitness. RESULTS: Removing the paralogs and distant homologs improved the overall performance of categorizing disease-causing and benign amino acid substitutions. CONCLUSION: The results show that a thorough evolutionary analysis followed by identification of orthologs improves the accuracy in predicting disease-causing missense mutations. We anticipate that this approach will be used as a reference in the interpretation of variants in other genetic diseases as well. Genet Med 18 10, 1029â1036
Scalar geometry and masses in Calabi-Yau string models
We study the geometry of the scalar manifolds emerging in the no-scale sector
of Kahler moduli and matter fields in generic Calabi-Yau string
compactifications, and describe its implications on scalar masses. We consider
both heterotic and orientifold models and compare their characteristics. We
start from a general formula for the Kahler potential as a function of the
topological compactification data and study the structure of the curvature
tensor. We then determine the conditions for the space to be symmetric and show
that whenever this is the case the heterotic and the orientifold models give
the same scalar manifold. We finally study the structure of scalar masses in
this type of geometries, assuming that a generic superpotential triggers
spontaneous supersymmetry breaking. We show in particular that their behavior
crucially depends on the parameters controlling the departure of the geometry
from the coset situation. We first investigate the average sGoldstino mass in
the hidden sector and its sign, and study the implications on vacuum
metastability and the mass of the lightest scalar. We next examine the soft
scalar masses in the visible sector and their flavor structure, and study the
possibility of realizing a mild form of sequestering relying on a global
symmetry.Comment: 36 pages, no figure
A consistent treatment for pion form factors in space-like and time-like regions
We write down some relevant matrix elements for the scattering and decay
processes of the pion by considering a quark-meson vertex function. The pion
charge and transition form factors , , and
are extracted from these matrix elements using a relativistic
quark model on the light-front. We found that, the form factors and
in the space-like region agree well with experiment.
Furthermore, the branching ratios of all observed decay modes of the neutral
pion, that are related to the form factors and
in the time-like region, are all consistent with the data as
well. Additionally, in the time-like region, which deals with the
nonvalence contribution, is also discussed.Comment: 24 pages, 6 figures, to appear in Phys. Rev.
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