The impact of propagation uncertainties on the potential Dark Matter contribution to the Fermi LAT mid-latitude gamma-ray data

We investigate the extent to which the uncertainties associated with the propagation of Galactic cosmic rays impact upon estimates for the gamma-ray flux from the mid-latitude region. We consider contributions from both standard astrophysical background (SAB) processes as well as resolved point sources. We have found that the uncertainties in the total gamma-ray flux from the mid-latitude region relating to propagation parameter values consistent with local B/C and Be10/Be9 data dominate by 1-2 orders of magnitude. These uncertainties are reduced to less than an order of magnitude when the normalisations of the SAB spectral components are fitted to the corresponding Fermi LAT data. We have found that for many propagation parameter configurations (PPCs) our fits improve when an extragalactic background (EGB) component is simultaneously fitted to the data. We also investigate the improvement in our fits when a flux contribution from neutralino dark matter (DM), described by the Minimal Supersymmetric Standard Model, was simultaneously fitted to the data. We consider three representative cases of neutralino DM for both Burkert and Einasto DM density profiles, in each case simultaneously fitting a boost factor of the DM contribution together with the SAB and EGB components. We have found that for several PPCs there are significant improvements in our fits, yielding both substantial EGB and DM components, where for a few of these PPCs the best-fit EGB component is consistent with recent estimates by the Fermi Collaboration.Comment: V2: 25 pages, 9 figures and 13 tables. Replaced to match version accepted for publication in PRD. Major revisions to address referee's comment

Solving the cosmic lithium problems with primordial late-decaying particles

We investigate the modifications to predictions for the abundances of light elements from standard Big-Bang nucleosynthesis when exotic late-decaying particles with lifetimes exceeding ~1 sec are prominent in the early Universe. Utilising a model-independent analysis of the properties of these long-lived particles, we identify the parameter space associated with models that are consistent with all observational data and hence resolve the much discussed discrepancies between observations and theoretical predictions for the abundances of Li^7 and Li^6.Comment: 6 pages, 3 figures, submitted to Physical Review D; minor changes to reference

Difficulties for Compact Composite Object Dark Matter

It has been suggested ``that DM particles are strongly interacting composite macroscopically large objects ... made of well known light quarks (or ... antiquarks)." In doing so it is argued that these compact composite objects (CCOs) are ``natural explanations of many observed data, such as [the] 511 keV line from the bulge of our galaxy" observed by INTEGRAL and the excess of diffuse gamma-rays in the 1-20 MeV band observed by COMPTEL. Here we argue that the atmospheres of positrons that surround CCOs composed of di-antiquark pairs in the favoured Colour-Flavour-Locked superconducting state are sufficiently dense as to stringently limit the penetration of interstellar electrons incident upon them, resulting in an extreme suppression of previously estimated rates of positronium, and hence the flux of 511 keV photons resulting from their decays, and also in the rate of direct electron-positron annihilations, which yield the MeV photons proposed to explain the 1-20 MeV excess. We also demonstrate that even if a fraction of positrons somehow penetrated to the surface of the CCOs, the extremely strong electric fields generated from the bulk antiquark matter would result in the destruction of positronium atoms long before they decay.Comment: 7 Pages, 4 Figures. Major changes invoke

Citizen Journalism at the Margins

Amidst burgeoning literature on citizen journalism, we still know relatively little about how and why genuinely marginalised groups seek to use this form of reporting to challenge their exclusion. In this article, we aim to address this gap by analysing two UK citizen journalism initiatives emanating from The Big Issue Foundation, a national homeless organisation, and Access Dorset, a regional charity for disabled and elderly people. These case studies are united by the authors’ involvement in both instances, primarily through designing and delivering bespoke citizen journalism education and mentoring. Based on over 40 hours of interviews with participants of the workshops and 36 hours of participant observation, we analyse the challenges participants faced in their journey to become citizen journalists. This included: low self-esteem, physical health and mental wellbeing, the need for accessible and adaptable technology, and overcoming fear associated with assuming a public voice. We also analyse marginalised groups’ attitudes to professional journalism and education, and its role in shaping journalistic identity and self-empowerment. Whilst demonstrably empowering and esteem building,our participants were acutely aware of societal power relations that were seemingly still beyond their ability to influence. Those who are marginalised are, nevertheless, in the best position to use citizen journalism as a conduit for social change, we argue - though challenges remain even at the grassroots level to foster and sustain participatory practices

Heavy dark matter through the Higgs portal

Abstract Motivated by Higgs Portal and Hidden Valley models, heavy particle dark matter that communicates with the supersymmetric Standard Model via pure Higgs sector interactions is considered. We show that a thermal relic abundance consistent with the measured density of dark matter is possible for masses up to ∼ 30 TeV. For dark matter masses above ∼ 1 TeV, non-perturbative Sommerfeld corrections to the annihilation rate are large, and have the potential to greatly affect indirect detection signals. For large dark matter masses, the Higgs-dark matter sector couplings are large and we show how such models may be given a UV completion within the context of so-called "Fat-Higgs" models. Higgs Portal dark matter provides an example of an attractive alternative to conventional MSSM neutralino dark matter that may evade discovery at the LHC, while still being within the reach of current and upcoming indirect detection experiments

Pulsars as the Source of the WMAP Haze

The WMAP haze is an excess in the 22 to 93 GHz frequency bands of WMAP extending about 10 degrees from the galactic center. We show that synchrotron emission from electron-positron pairs injected into the interstellar medium by the galactic population of pulsars with energies in the 1 to 100 GeV range can explain the frequency spectrum of the WMAP haze and the drop in the average haze power with latitude. The same spectrum of high energy electron-positron pairs from pulsars, which gives rise to the haze, may also generate the observed excesses in AMS, HEAT and PAMELA. We discuss the spatial morphology of the pulsar synchrotron signal and its deviation from spherical symmetry, which may provide an avenue to determine the pulsar contribution to the haze.Comment: 18 pages, 4 figures. Corrected errors in fig 1-3 and added discussion of the detailed spatial morphology of the haze signa

A Systematic Review of the Efficacy and Toxicity of Brachytherapy Boost Combined with External Beam Radiotherapy for Nonmetastatic Prostate Cancer

CONTEXT: The optimum use of brachytherapy (BT) combined with external beam radiotherapy (EBRT) for localised/locally advanced prostate cancer (PCa) remains uncertain.OBJECTIVE: To perform a systematic review to determine the benefits and harms of EBRT-BT.EVIDENCE ACQUISITION: Ovid MEDLINE, Embase, and EBM Reviews-Cochrane Central Register of Controlled Trials databases were systematically searched for studies published between January 1, 2000 and June 7, 2022, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Eligible studies compared low- or high-dose-rate EBRT-BT against EBRT ± androgen deprivation therapy (ADT) and/or radical prostatectomy (RP) ± postoperative radiotherapy (RP ± EBRT). The main outcomes were biochemical progression-free survival (bPFS), severe late genitourinary (GU)/gastrointestinal toxicity, metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS), at/beyond 5 yr. Risk of bias was assessed and confounding assessment was performed. A meta-analysis was performed for randomised controlled trials (RCTs).EVIDENCE SYNTHESIS: Seventy-three studies were included (two RCTs, seven prospective studies, and 64 retrospective studies). Most studies included participants with intermediate-or high-risk PCa. Most studies, including both RCTs, used ADT with EBRT-BT. Generally, EBRT-BT was associated with improved bPFS compared with EBRT, but similar MFS, CSS, and OS. A meta-analysis of the two RCTs showed superior bPFS with EBRT-BT (estimated fixed-effect hazard ratio [HR] 0.54 [95% confidence interval {CI} 0.40-0.72], p &lt; 0.001), with absolute improvements in bPFS at 5-6 yr of 4.9-16%. However, no difference was seen for MFS (HR 0.84 [95% CI 0.53-1.28], p = 0.4) or OS (HR 0.87 [95% CI 0.63-1.19], p = 0.4). Fewer studies examined RP ± EBRT. There is an increased risk of severe late GU toxicity, especially with low-dose-rate EBRT-BT, with some evidence of increased prevalence of severe GU toxicity at 5-6 yr of 6.4-7% across the two RCTs.CONCLUSIONS: EBRT-BT can be considered for unfavourable intermediate/high-risk localised/locally advanced PCa in patients with good urinary function, although the strength of this recommendation based on the European Association of Urology guideline methodology is weak given that it is based on improvements in biochemical control.PATIENT SUMMARY: We found good evidence that radiotherapy combined with brachytherapy keeps prostate cancer controlled for longer, but it could lead to worse urinary side effects than radiotherapy without brachytherapy, and its impact on cancer spread and patient survival is less clear.</p

A Systematic Review of the Efficacy and Toxicity of Brachytherapy Boost Combined with External Beam Radiotherapy for Nonmetastatic Prostate Cancer

CONTEXT: The optimum use of brachytherapy (BT) combined with external beam radiotherapy (EBRT) for localised/locally advanced prostate cancer (PCa) remains uncertain.OBJECTIVE: To perform a systematic review to determine the benefits and harms of EBRT-BT.EVIDENCE ACQUISITION: Ovid MEDLINE, Embase, and EBM Reviews-Cochrane Central Register of Controlled Trials databases were systematically searched for studies published between January 1, 2000 and June 7, 2022, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Eligible studies compared low- or high-dose-rate EBRT-BT against EBRT ± androgen deprivation therapy (ADT) and/or radical prostatectomy (RP) ± postoperative radiotherapy (RP ± EBRT). The main outcomes were biochemical progression-free survival (bPFS), severe late genitourinary (GU)/gastrointestinal toxicity, metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS), at/beyond 5 yr. Risk of bias was assessed and confounding assessment was performed. A meta-analysis was performed for randomised controlled trials (RCTs).EVIDENCE SYNTHESIS: Seventy-three studies were included (two RCTs, seven prospective studies, and 64 retrospective studies). Most studies included participants with intermediate-or high-risk PCa. Most studies, including both RCTs, used ADT with EBRT-BT. Generally, EBRT-BT was associated with improved bPFS compared with EBRT, but similar MFS, CSS, and OS. A meta-analysis of the two RCTs showed superior bPFS with EBRT-BT (estimated fixed-effect hazard ratio [HR] 0.54 [95% confidence interval {CI} 0.40-0.72], p &lt; 0.001), with absolute improvements in bPFS at 5-6 yr of 4.9-16%. However, no difference was seen for MFS (HR 0.84 [95% CI 0.53-1.28], p = 0.4) or OS (HR 0.87 [95% CI 0.63-1.19], p = 0.4). Fewer studies examined RP ± EBRT. There is an increased risk of severe late GU toxicity, especially with low-dose-rate EBRT-BT, with some evidence of increased prevalence of severe GU toxicity at 5-6 yr of 6.4-7% across the two RCTs.CONCLUSIONS: EBRT-BT can be considered for unfavourable intermediate/high-risk localised/locally advanced PCa in patients with good urinary function, although the strength of this recommendation based on the European Association of Urology guideline methodology is weak given that it is based on improvements in biochemical control.PATIENT SUMMARY: We found good evidence that radiotherapy combined with brachytherapy keeps prostate cancer controlled for longer, but it could lead to worse urinary side effects than radiotherapy without brachytherapy, and its impact on cancer spread and patient survival is less clear.</p

Dark Matter Searches: The Nightmare Scenario

The unfortunate case where the Large Hadron Collider (LHC) fails to discover physics Beyond the Standard Model (BSM) is sometimes referred to as the "Nightmare scenario" of particle physics. We study the consequences of this hypothetical scenario for Dark Matter (DM), in the framework of the constrained Minimal Supersymmetric Standard Model (cMSSM). We evaluate the surviving regions of the cMSSM parameter space after null searches at the LHC, using several different LHC configurations, and study the consequences for DM searches with ton-scale direct detectors and the IceCube neutrino telescope. We demonstrate that ton-scale direct detection experiments will be able to conclusively probe the cMSSM parameter space that would survive null searches at the LHC with 100fb$^{-1}$ of integrated luminosity at 14TeV. We also demonstrate that IceCube (80 strings plus DeepCore) will be able to probe as much as 17% of the currently favoured parameter space after 5 years of observation.Comment: V2: 24 pages, 6 figures, 4 tables. Replaced to match version published in JCAP. Minor revisions made to address referee's comment