11,997 research outputs found
Spatial Geometry and the Wu-Yang Ambiguity
We display continuous families of SU(2) vector potentials in 3
space dimensions which generate the same magnetic field (with det
). These Wu-Yang families are obtained from the Einstein equation
derived recently via a local map of the gauge field system
into a spatial geometry with -tensor and
connection with torsion defined from gauge covariant
derivatives of .Comment: Based on talks given by R. Khuri at PASCOS-94, Syracuse University,
May 1994 and at Gursey Memorial Conference I, Istanbul, June 1994, 7 pages,
TeX (typo in first Author's name is corrected.
Nephrogenic systemic fibrosis risk and liver disease.
Objective. Evaluate the incidence of nephrogenic systemic fibrosis (NSF) in patients with liver disease in the peritransplant period. Materials and Methods. This IRB approved study retrospectively reviewed patients requiring transplantation for cirrhosis, hepatocellular carcinoma (HCC), or both from 2003 to 2013. Records were reviewed identifying those having gadolinium enhanced MRI within 1 year of posttransplantation to document degree of liver disease, renal disease, and evidence for NSF. Results. Gadolinium-enhanced MRI was performed on 312 of 837 patients, including 23 with severe renal failure (GFR < 30 mL/min/1.73 cm(2)) and 289 with GFR > 30. Two of 23 patients with renal failure developed NSF compared to zero NSF cases in 289 patients with GFR > 30 (0/289; P < 0.003). High dose gadodiamide was used in the two NSF cases. There was no increased incidence of NSF with severe liver disease (1/71) compared to nonsevere liver disease (1/241; P = 0.412). Conclusion. Renal disease is a risk factor for NSF, but in our small sample our evidence suggests liver disease is not an additional risk factor, especially if a low-risk gadolinium agent is used. Noting that not all patients received high-risk gadolinium, a larger study focusing on patients receiving high-risk gadolinium is needed to further evaluate NSF risk in liver disease in the peritransplant period
Linearly polarized X-ray flares following short gamma-ray bursts
Soft X-ray flares were detected to follow the short-duration gamma-ray burst
GRB 050724. The temporal properties of the flares suggest that they are likely
due to the late time activity of the central engine. We argue that if short
GRBs are generated through compact star mergers, as is supported by the recent
observations, the jet powering the late X-ray flares must be launched via
magnetic processes rather than via neutrino-antineutrino annihilations. As a
result, the X-ray flares following short GRBs are expected to be linearly
polarized. The argument may also apply to the X-ray flares following long GRBs.
Future observations with the upcoming X-ray polarimeters will test this
prediction.Comment: 4 pages (no figure), accepted for publication in ApJL, typos
correcte
A Compact Microchip-Based Atomic Clock Based on Ultracold Trapped Rb Atoms
We propose a compact atomic clock based on ultracold Rb atoms that are
magnetically trapped near the surface of an atom microchip. An interrogation
scheme that combines electromagnetically-induced transparency (EIT) with
Ramsey's method of separated oscillatory fields can achieve atomic shot-noise
level performance of 10^{-13}/sqrt(tau) for 10^6 atoms. The EIT signal can be
detected with a heterodyne technique that provides noiseless gain; with this
technique the optical phase shift of a 100 pW probe beam can be detected at the
photon shot-noise level. Numerical calculations of the density matrix equations
are used to identify realistic operating parameters at which AC Stark shifts
are eliminated. By considering fluctuations in these parameters, we estimate
that AC Stark shifts can be canceled to a level better than 2*10^{-14}. An
overview of the apparatus is presented with estimates of duty cycle and power
consumption.Comment: 15 pages, 11 figures, 5 table
miR-9 Acts as an OncomiR in Prostate Cancer through Multiple Pathways That Drive Tumour Progression and Metastasis
Identification of dysregulated microRNAs (miRNAs) in prostate cancer is critical not only for diagnosis, but also differentiation between the aggressive and indolent forms of the disease. miR-9 was identified as an oncomiR through both miRNA panel RT-qPCR as well as high-throughput sequencing analysis of the human P69 prostate cell line as compared to its highly tumorigenic and metastatic subline M12, and found to be consistently upregulated in other prostate cell lines including DU-145 and PC3. While miR-9 has been characterized as dysregulated either as an oncomiR or tumour suppressor in a variety of other cancers including breast, ovarian, and nasopharyngeal carcinomas, it has not been previously evaluated and proven as an oncomiR in prostate cancer. miR-9 was confirmed an oncomiR when found to be overexpressed in tumour tissue as compared to adjacent benign glandular epithelium through laser-capture microdissection of radical prostatectomy biopsies. Inhibition of miR-9 resulted in reduced migratory and invasive potential of the M12 cell line, and reduced tumour growth and metastases in male athymic nude mice. Analysis showed that miR-9 targets e-cadherin and suppressor of cytokine signalling 5 (SOCS5), but not NF-ĸB mRNA. Expression of these proteins was shown to be affected by modulation in expression of miR-9
Optical computing of quantum revivals
Interference is the mechanism through which waves can be structured into the
most fascinating patterns. While for sensing, imaging, trapping, or in
fundamental investigations, structured waves play nowadays an important role
and are becoming subject of many interesting studies. Using a coherent optical
field as a probe, we show how to structure light into distributions presenting
collapse and revival structures in its wavefront. These distributions are
obtained from the Fourier spectrum of an arrangement of aperiodic diffracting
structures. Interestingly, the resulting interference may present quasiperiodic
structures of diffraction peaks on a number of distance scales, even though the
diffracting structure is not periodic. We establish an analogy with revival
phenomena in the evolution of quantum mechanical systems and illustrate this
computation numerically and experimentally, obtaining excellent agreement with
the proposed theory.Comment: 10 pages, 4 figure
Malaria parasite translocon structure and mechanism of effector export.
The putative Plasmodium translocon of exported proteins (PTEX) is essential for transport of malarial effector proteins across a parasite-encasing vacuolar membrane into host erythrocytes, but the mechanism of this process remains unknown. Here we show that PTEX is a bona fide translocon by determining structures of the PTEX core complex at near-atomic resolution using cryo-electron microscopy. We isolated the endogenous PTEX core complex containing EXP2, PTEX150 and HSP101 from Plasmodium falciparum in the 'engaged' and 'resetting' states of endogenous cargo translocation using epitope tags inserted using the CRISPR-Cas9 system. In the structures, EXP2 and PTEX150 interdigitate to form a static, funnel-shaped pseudo-seven-fold-symmetric protein-conducting channel spanning the vacuolar membrane. The spiral-shaped AAA+ HSP101 hexamer is tethered above this funnel, and undergoes pronounced compaction that allows three of six tyrosine-bearing pore loops lining the HSP101 channel to dissociate from the cargo, resetting the translocon for the next threading cycle. Our work reveals the mechanism of P. falciparum effector export, and will inform structure-based design of drugs targeting this unique translocon
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